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mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use.

Author(s): Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl R...

Neuropsychopharmacology. 2020 May 15;: Authors: Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, C...

Article GUID: 32413893
Extra-striatal D2/3 receptor availability in youth at risk for addiction.

Author(s): Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Ségu...

Neuropsychopharmacology. 2020 Apr 07;: Authors: Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, S&...

Article GUID: 32259831
Sex-specific contribution of DHEA-cortisol ratio to prefrontal-hippocampal structural development, cognitive abilities and personality traits.

Author(s): Farooqi NAI, Scotti M, Yu A, Lew J, Monnier P, Botteron KN, Campbell BC, Booij L, Herba CM, Séguin JR, Castellanos-Ryan N, McCracken JT, Nguyen TV

J Neuroendocrinol. 2019 Feb;31(2):e12682 Authors: Farooqi NAI, Scotti M, Yu A, Lew J, Monnier P, Botteron KN, Campbell BC, Booij L, Herba CM, Séguin JR, Castellanos-Ryan N, McCracken JT, Nguyen TV

Article GUID: 30597689
Title:Sex-specific contribution of DHEA-cortisol ratio to prefrontal-hippocampal structural development, cognitive abilities and personality traits.
Authors:Farooqi NAI,  Scotti M,  Yu A,  Lew J,  Monnier P,  Botteron KN,  Campbell BC,  Booij L,  Herba CM,  Séguin JR,  Castellanos-Ryan N,  McCracken JT,  Nguyen TV
Link:https://www.ncbi.nlm.nih.gov/pubmed/30597689?dopt=Abstract
Category:J Neuroendocrinol
PMID:30597689
Dept Affiliation: PSYCHOLOGY
1 Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
2 Department of Psychology, McGill University, Montreal, Quebec, Canada.
3 Department of Obstetrics-Gynecology, McGill University Health Center, Montreal, Quebec, Canada.
4 Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.
5 Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri.
6 Brain Development Cooperative Group.
7 Department of Anthropology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
8 Department of Psychology, Concordia University, Montreal, Quebec, Canada.
9 CHU Sainte Justine Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.
10 Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada.
11 Department of Psychiatry and Addiction, University of Montreal, Montreal, Quebec, Canada.
12 School of Psychoeducation, University of Montreal, Montreal, Quebec, Canada.
13 Department of Child and Adolescent Psychiatry, University of California in Los Angeles, Los Angeles, California.

Description:

Sex-specific contribution of DHEA-cortisol ratio to prefrontal-hippocampal structural development, cognitive abilities and personality traits.

J Neuroendocrinol. 2019 Feb;31(2):e12682

Authors: Farooqi NAI, Scotti M, Yu A, Lew J, Monnier P, Botteron KN, Campbell BC, Booij L, Herba CM, Séguin JR, Castellanos-Ryan N, McCracken JT, Nguyen TV

Abstract

Although dehydroepiandrosterone (DHEA) may exert neuroprotective effects in the developing brain, prolonged or excessive elevations in cortisol may exert neurotoxic effects. The ratio between DHEA and cortisol (DC ratio) has been linked to internalising and externalising disorders, as well as cognitive performance, supporting the clinical relevance of this hormonal ratio during development. However, the brain mechanisms by which these effects may be mediated have not yet been identified. Furthermore, although there is evidence that the effects of cortisol in the central nervous system may be sexually dimorphic in humans, the opposite is true for DHEA, with human studies showing no sex-specific associations in cortical thickness, cortico-amygdalar or cortico-hippocampal structural covariance. Therefore, it remains unclear whether sex moderates the developmental associations between DC ratio, brain structure, cognition and behaviour. In the present study, we examined the associations between DC ratio, structural covariance of the hippocampus with whole-brain cortical thickness, and measures of personality, behaviour and cognition in a longitudinal sample of typically developing children, adolescents and young adults aged 6-22 years (N = 225 participants [F = 128]; 355 scans [F = 208]), using mixed effects models that accounted for both within- and between-subject variances. We found sex-specific interactions between DC ratio and anterior cingulate cortex-hippocampal structural covariance, with higher DC ratios being associated with a more negative covariance between these structures in girls, and a more positive covariance in boys. Furthermore, the negative prefrontal-hippocampal structural covariance found in girls was associated with higher verbal memory and mathematical ability, whereas the positive covariance found in boys was associated with lower cooperativeness and reward dependence personality traits. These findings support the notion that the ratio between DHEA and cortisol levels may contribute, at least in part, to the development of sex differences in cognitive abilities, as well as risk for internalising/externalising disorders, via an alteration in prefrontal-hippocampal structure during the transition from childhood to adulthood.

PMID: 30597689 [PubMed - in process]