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Topographical distribution of Aβ predicts progression to dementia in Aβ positive mild cognitive impairment

Author(s): Pascoal TA, Therriault J, Mathotaarachchi S, Kang MS, Shin M, Benedet AL, Chamoun M, Tissot C, Lussier F, Mohaddes S, Soucy JP, Massarweh G,...

INTRODUCTION: Abnormal brain amyloid beta (Aβ) is typically assessed in vivo using global concentrations from cerebrospinal fluid and positron emission tomography (PET). However, it is unknown...

Article GUID: 32582834
Title:Topographical distribution of Aβ predicts progression to dementia in Aβ positive mild cognitive impairment
Authors:Pascoal TA,  Therriault J,  Mathotaarachchi S,  Kang MS,  Shin M,  Benedet AL,  Chamoun M,  Tissot C,  Lussier F,  Mohaddes S,  Soucy JP,  Massarweh G,  Gauthier S,  Rosa-Neto P, 
Link:https://pubmed.ncbi.nlm.nih.gov/32582834/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1deGMjvjVspk9gsE
DOI:10.1002/dad2.12037
Category:
PMID:32582834
Dept Affiliation: PERFORM
1 Translational Neuroimaging Laboratory Alzheimer's Disease Research Unit The McGill University Research Centre for Studies in Aging McGill University Montreal Quebec Canada.
2 Department of Neurology and Neurosurgery McGill University Montreal Quebec Canada.
3 Montreal Neurological Institute Montreal Quebec Canada.
4 PERFORM Centre Concordia University Montreal Quebec Canada.

Description:

INTRODUCTION: Abnormal brain amyloid beta (Aß) is typically assessed in vivo using global concentrations from cerebrospinal fluid and positron emission tomography (PET). However, it is unknown whether the assessment of the topographical distribution of Aß pathology can provide additional information to identify, among global Aß positive individuals, those destined for dementia.