Keyword search (3,172 papers available)


Recommendations of the 5th Canadian Consensus Conference on the diagnosis and treatment of dementia.

Author(s): Ismail Z, Black SE, Camicioli R, Chertkow H, Herrmann N, Laforce R, Montero-Odasso M, Rockwood K, Rosa-Neto P, Seitz D, Sivananthan S, Smith...

Alzheimers Dement. 2020 Jul 29;: Authors: Ismail Z, Black SE, Camicioli R, Chertkow H, Herrmann N, Laforce R, Montero-Odasso M, Rockwood K, Rosa-Neto P, Seitz D, Sivananthan S, Smith EE, Soucy JP,...

Article GUID: 32725777
Clinical judgement is paramount when performing cognitive screening during COVID-19.

Author(s): Phillips NA, Andrews M, Chertkow H, Pichora-Fuller MK, Rockwood K, Wittich W

J Am Geriatr Soc. 2020 May 12;: Authors: Phillips NA, Andrews M, Chertkow H, Pichora-Fuller MK, Rockwood K, Wittich W PMID: 32396983 [PubMed - as supplied by publisher]

Article GUID: 32396983
Special issues on using the MoCA for remote assessment during COVID-19 2.

Author(s): Phillips NA, Chertkow H, Pichora-Fuller MK, Wittich W

J Am Geriatr Soc. 2020 Apr 06;: Authors: Phillips NA, Chertkow H, Pichora-Fuller MK, Wittich W PMID: 32253754 [PubMed - as supplied by publisher]

Article GUID: 32253754
The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study.

Author(s): Chertkow H, Borrie M, Whitehead V, Black SE, Feldman HH, Gauthier S, Hogan DB, Masellis M, McGilton K, Rockwood K, Tierney MC, Andrew M, Hsi...

Can J Neurol Sci. 2019 Jul 16;:1-13 Authors: Chertkow H, Borrie M, Whitehead V, Black SE, Feldman HH, Gauthier S, Hogan DB, Masellis M, McGilton K, Rockwood K, Tierney MC, Andrew M, Hsiung GR, Cam...

Article GUID: 31309917
Structural brain differences between monolingual and multilingual patients with mild cognitive impairment and Alzheimer disease: Evidence for cognitive reserve.

Author(s): Duncan HD, Nikelski J, Pilon R, Steffener J, Chertkow H, Phillips NA

Neuropsychologia. 2018 01 31;109:270-282 Authors: Duncan HD, Nikelski J, Pilon R, Steffener J, Chertkow H, Phillips NA

Article GUID: 29287966
Functional and anatomical memory indices in patients with or at risk for Alzheimer's disease.

Author(s): Phillips NA, Chertkow H, Leblanc MM, Pim H, Murtha S

J Int Neuropsychol Soc. 2004 Mar;10(2):200-10 Authors: Phillips NA, Chertkow H, Leblanc MM, Pim H, Murtha S

Article GUID: 15012840
Title:Structural brain differences between monolingual and multilingual patients with mild cognitive impairment and Alzheimer disease: Evidence for cognitive reserve.
Authors:Duncan HD,  Nikelski J,  Pilon R,  Steffener J,  Chertkow H,  Phillips NA
Link:https://www.ncbi.nlm.nih.gov/pubmed/29287966?dopt=Abstract
Category:Neuropsychologia
PMID:29287966
Dept Affiliation: IMAGING
1 Department of Psychology, Concordia University, Montréal, QC, Canada; Centre for Research in Human Development, Montréal, QC, Canada.
2 Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal, QC, Canada.
3 Department of Psychology, Concordia University, Montréal, QC, Canada; Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada; Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada.
4 Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal, QC, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.
5 Department of Psychology, Concordia University, Montréal, QC, Canada; Centre for Research in Human Development, Montréal, QC, Canada; Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal, QC, Canada; Centre for Research on Brain, Language, and Music, Montréal, QC, Canada. Electronic address: natalie.phillips@concordia.ca.

Description:

Structural brain differences between monolingual and multilingual patients with mild cognitive impairment and Alzheimer disease: Evidence for cognitive reserve.

Neuropsychologia. 2018 01 31;109:270-282

Authors: Duncan HD, Nikelski J, Pilon R, Steffener J, Chertkow H, Phillips NA

Abstract

Two independent lines of research provide evidence that speaking more than one language may 1) contribute to increased grey matter in healthy younger and older adults and 2) delay cognitive symptoms in mild cognitive impairment (MCI) or Alzheimer disease (AD). We examined cortical thickness and tissue density in monolingual and multilingual MCI and AD patients matched (within Diagnosis Groups) on demographic and cognitive variables. In medial temporal disease-related (DR) areas, we found higher tissue density in multilingual MCIs versus monolingual MCIs, but similar or lower tissue density in multilingual AD versus monolingual AD, a pattern consistent with cognitive reserve in AD. In areas related to language and cognitive control (LCC), both multilingual MCI and AD patients had thicker cortex than the monolinguals. Results were largely replicated in our native-born Canadian MCI participants, ruling out immigration as a potential confound. Finally, multilingual patients showed a correlation between cortical thickness in LCC regions and performance on episodic memory tasks. Given that multilinguals and monolinguals were matched on memory functioning, this suggests that increased gray matter in these regions may provide support to memory functioning. Our results suggest that being multilingual may contribute to increased gray matter in LCC areas and may also delay the cognitive effects of disease-related atrophy.

PMID: 29287966 [PubMed - indexed for MEDLINE]