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DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents.

Author(s): Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L

J Affect Disord. 2020 Jun 15;271:160-168 Authors: Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L

Article GUID: 32479312
The Neuroscience of Sadness: A Multidisciplinary Synthesis and Collaborative Review for the Human Affectome Project.

Author(s): Arias JA, Williams C, Raghvani R, Aghajani M, Baez S, Belzung C, Booij L, Busatto G, Chiarella J, Fu CH, Ibanez A, Liddell BJ, Lowe L, Penni...

Neurosci Biobehav Rev. 2020 Jan 27;: Authors: Arias JA, Williams C, Raghvani R, Aghajani M, Baez S, Belzung C, Booij L, Busatto G, Chiarella J, Fu CH, Ibanez A, Liddell BJ, Lowe L, Penninx BWJH, R...

Article GUID: 32001274
Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression.

Author(s): Tozzi L, Farrell C, Booij L, Doolin K, Nemoda Z, Szyf M, Pomares FB, Chiarella J, O'Keane V, Frodl T

Neuropsychopharmacology. 2018 04;43(5):1138-1145 Authors: Tozzi L, Farrell C, Booij L, Doolin K, Nemoda Z, Szyf M, Pomares FB, Chiarella J, O'Keane V, Frodl T

Article GUID: 29182159
Functional connectivity across social inclusion and exclusion is related to peer victimization and depressive symptoms in young adults.

Author(s): McIver TA, Bosma RL, Goegan S, Sandre A, Klassen J, Chiarella J, Booij L, Craig W

J Affect Disord. 2019 Apr 22;253:366-375 Authors: McIver TA, Bosma RL, Goegan S, Sandre A, Klassen J, Chiarella J, Booij L, Craig W

Article GUID: 31078837
Title:Functional connectivity across social inclusion and exclusion is related to peer victimization and depressive symptoms in young adults.
Authors:McIver TA,  Bosma RL,  Goegan S,  Sandre A,  Klassen J,  Chiarella J,  Booij L,  Craig W
Link:https://www.ncbi.nlm.nih.gov/pubmed/31078837?dopt=Abstract
Category:J Affect Disord
PMID:31078837
Dept Affiliation: PSYCHOLOGY
1 Centre for Neuroscience Studies, Queen's University, Botterell Hall, 18 Stuart Street, Kingston, Ontario, K7L 3N6, Canada.
2 Department of Psychology, Queen's University, Humphrey Hall, 62 Arch Street, Kingston, Ontario, K7L 3N6, Canada.
3 Department of Psychology, Queen's University, Humphrey Hall, 62 Arch Street, Kingston, Ontario, K7L 3N6, Canada; Department of Psychology, Concordia University, 7141 Sherbrooke Street West, Montreal, Québec H4B 1R6, Canada. Electronic address: linda.booij@concordia.ca.

Description:

Functional connectivity across social inclusion and exclusion is related to peer victimization and depressive symptoms in young adults.

J Affect Disord. 2019 Apr 22;253:366-375

Authors: McIver TA, Bosma RL, Goegan S, Sandre A, Klassen J, Chiarella J, Booij L, Craig W

Abstract

BACKGROUND: Peer victimization is associated with increased risk for depression, as well as increased neural response to social exclusion in the anterior cingulate cortex (ACC) and the amygdala. Altered functional connectivity (FxC) of fronto-limbic circuitry is associated with risk for various affective disorders. The present study examined the relationship between fronto-limbic FxC during social exclusion, prior peer victimization experience and depressive symptoms.

METHODS: Three mutually exclusive groups were formed: peer victimized (with a history of peer victimization), defenders (history of defending peers), and controls (no prior peer victimization experience) (n?=?15/group; Mage?=?17.7 years). Functional Magnetic Resonance Imaging data were collected while participants completed the Cyberball paradigm (simulating the experience of social exclusion). FxC between the Medial Prefrontal Cortex (MPFC), ACC, right insula and left amygdala, was compared between groups and examined in relation to depressive symptoms.

RESULTS: Prior peer victimization experience was associated with differences in fronto-limbic FxC across social inclusion and exclusion. Defenders displayed distinct shifts in FxC across the transition from being included to excluded. Peer victimized individuals exhibited a unique pattern of amygdala-specific FxC during inclusive interaction with peers, and in the continuous FxC across inclusion and exclusion. FxC of the MPFC-amygdala across inclusion and exclusion moderated the relationship between peer victimization and depressive symptoms.

LIMITATIONS: Small sample size and cross-sectional design limit interpretation of the findings.

CONCLUSIONS: Peer victimized individuals who exhibit continuous positive FxC of the MPFC-left amygdala across inclusion and exclusion may be at greater risk for depressive symptoms.

PMID: 31078837 [PubMed - as supplied by publisher]