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Localization Accuracy of Distributed Inverse Solutions for Electric and Magnetic Source Imaging of Interictal Epileptic Discharges in Patients with Focal Epilepsy.

Author(s): Heers M, Chowdhury RA, Hedrich T, Dubeau F, Hall JA, Lina JM, Grova C, Kobayashi E

Brain Topogr. 2016 Jan;29(1):162-81 Authors: Heers M, Chowdhury RA, Hedrich T, Dubeau F, Hall JA, Lina JM, Grova C, Kobayashi E

Article GUID: 25609211
MEG-EEG Information Fusion and Electromagnetic Source Imaging: From Theory to Clinical Application in Epilepsy.

Author(s): Chowdhury RA, Zerouali Y, Hedrich T, Heers M, Kobayashi E, Lina JM, Grova C

Brain Topogr. 2015 Nov;28(6):785-812 Authors: Chowdhury RA, Zerouali Y, Hedrich T, Heers M, Kobayashi E, Lina JM, Grova C

Article GUID: 26016950
Clinical yield of magnetoencephalography distributed source imaging in epilepsy: A comparison with equivalent current dipole method.

Author(s): Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C

Hum Brain Mapp. 2018 01;39(1):218-231 Authors: Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C

Article GUID: 29024165
Reproducibility of EEG-MEG fusion source analysis of interictal spikes: Relevance in presurgical evaluation of epilepsy.

Author(s): Chowdhury RA, Pellegrino G, Aydin Ü, Lina JM, Dubeau F, Kobayashi E, Grova C

Hum Brain Mapp. 2018 02;39(2):880-901 Authors: Chowdhury RA, Pellegrino G, Aydin Ü, Lina JM, Dubeau F, Kobayashi E, Grova C

Article GUID: 29164737
Complex patterns of spatially extended generators of epileptic activity: Comparison of source localization methods cMEM and 4-ExSo-MUSIC on high resolution EEG and MEG data.

Author(s): Chowdhury RA, Merlet I, Birot G, Kobayashi E, Nica A, Biraben A, Wendling F, Lina JM, Albera L, Grova C...

Complex patterns of spatially extended generators of epileptic activity: Comparison of source localization methods cMEM and 4-ExSo-MUSIC on high resolution EEG and MEG data.
Neuroimage. 2016 De...

Article GUID: 27561712
Title:Clinical yield of magnetoencephalography distributed source imaging in epilepsy: A comparison with equivalent current dipole method.
Authors:Pellegrino G,  Hedrich T,  Chowdhury RA,  Hall JA,  Dubeau F,  Lina JM,  Kobayashi E,  Grova C
Link:https://www.ncbi.nlm.nih.gov/pubmed/29024165?dopt=Abstract
DOI:10.1002/hbm.23837
Category:Hum Brain Mapp
PMID:29024165
Dept Affiliation: PERFORM
1 Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University, Montreal, Quebec, Canada.
2 Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
3 IRCCS Fondazione San Camillo Hospital, Venice, Italy.
4 Departement de Génie Electrique, Ecole de Technologie Supérieure, Montreal, Quebec, Canada.
5 Centre De Recherches En Mathématiques, Montreal, Quebec, Canada.
6 Centre D'études Avancées En Médecine Du Sommeil, Centre De Recherche De L'hôpital Sacré-Coeur De Montréal, Montreal, Quebec, Canada.
7 Physics Department and PERFORM Centre, Concordia University, Montreal, Quebec, Canada.

Description:

Clinical yield of magnetoencephalography distributed source imaging in epilepsy: A comparison with equivalent current dipole method.

Hum Brain Mapp. 2018 01;39(1):218-231

Authors: Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C

Abstract

OBJECTIVE: Source localization of interictal epileptic discharges (IEDs) is clinically useful in the presurgical workup of epilepsy patients. It is usually obtained by equivalent current dipole (ECD) which localizes a point source and is the only inverse solution approved by clinical guidelines. In contrast, magnetic source imaging using distributed methods (dMSI) provides maps of the location and the extent of the generators, but its yield has not been clinically validated. We systematically compared ECD versus dMSI performed using coherent Maximum Entropy on the Mean (cMEM), a method sensitive to the spatial extent of the generators.

METHODS: 340 source localizations of IEDs derived from 49 focal epilepsy patients with foci well-defined through intracranial EEG, MRI lesions, and surgery were analyzed. The comparison was based on the assessment of the sublobar concordance with the focus and of the distance between the source and the focus.

RESULTS: dMSI sublobar concordance was significantly higher than ECD (81% vs 69%, P?<?0.001), especially for extratemporal lobe sources (dMSI?=?84%; ECD?=?67%, P?<?0.001) and for seizure free patients (dMSI?=?83%; ECD?=?70%, P?<?0.001). The median distance from the focus was 4.88 mm for ECD and 3.44 mm for dMSI (P?<?0.001). ECD dipoles were often wrongly localized in deep brain regions.

CONCLUSIONS: dMSI using cMEM exhibited better accuracy. dMSI also offered the advantage of recovering more realistic maps of the generator, which could be exploited for neuronavigation aimed at targeting invasive EEG and surgical resection. Therefore, dMSI may be preferred to ECD in clinical practice. Hum Brain Mapp 39:218-231, 2018. © 2017 Wiley Periodicals, Inc.

PMID: 29024165 [PubMed - indexed for MEDLINE]