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A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.

Author(s): D'Cunha TM, Chisholm A, Hryhorczuk C, Fulton S, Shalev U

RATIONAL: Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors. OBJECTIVES: We investigated the...

Article GUID: 31811350
Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones.

Author(s): Sedki F, Gardner Gregory J, Luminare A, D'Cunha TM, Shalev U

Psychopharmacology (Berl). 2015 Oct;232(20):3773-82 Authors: Sedki F, Gardner Gregory J, Luminare A, D'Cunha TM, Shalev U

Article GUID: 26246318
Augmentation of Heroin Seeking Following Chronic Food Restriction in the Rat: Differential Role for Dopamine Transmission in the Nucleus Accumbens Shell and Core.

Author(s): D'Cunha TM, Daoud E, Rizzo D, Bishop AB, Russo M, Mourra G, Hamel L, Sedki F, Shalev U

Neuropsychopharmacology. 2017 Apr;42(5):1136-1145 Authors: D'Cunha TM, Daoud E, Rizzo D, Bishop AB, Russo M, Mourra G, Hamel L, Sedki F, Shalev U

Article GUID: 27824052
Title:Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones.
Authors:Sedki F,  Gardner Gregory J,  Luminare A,  D'Cunha TM,  Shalev U
Link:https://www.ncbi.nlm.nih.gov/pubmed/26246318?dopt=Abstract
Category:Psychopharmacology (Berl)
PMID:26246318
Dept Affiliation: CSBN
1 Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, Canada.

Description:

Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones.

Psychopharmacology (Berl). 2015 Oct;232(20):3773-82

Authors: Sedki F, Gardner Gregory J, Luminare A, D'Cunha TM, Shalev U

Abstract

RATIONALE: Food restriction augments heroin seeking in chronically food-restricted male rats under withdrawal, an effect not yet examined in female rats. Importantly, women and female rats possess an increased vulnerability to drugs of abuse, which may be mediated by fluctuations in ovarian hormones.

OBJECTIVES: We investigated the role of estradiol and progesterone in augmented heroin seeking in chronically food-restricted female rats, under withdrawal.

METHODS: Female rats self-administered heroin for 10-12 days and were then allowed unrestricted (sated) or restricted access to food (FDR; ~10 % reduction in body weight) for 14 days. On day 14, rats underwent a heroin-seeking test. Exp. 1: Rats underwent ovariectomy or sham surgery and were treated with a low dose of estradiol (5.0 % in cholesterol; subcutaneous capsule). Exp. 2: Rats underwent ovariectomy and were administered with a high dose of estradiol (0.5 mg/kg; subcutaneous) for 8 days before testing. Exp. 3: Progesterone injections (2.0 mg/kg; subcutaneous) were administered 24 h and 2 h before testing.

RESULTS: Food restriction resulted in augmented heroin seeking, compared to sated controls. While ovariectomy had no effect, estradiol replacement attenuated the food restriction effect. Injections of progesterone had no effect on heroin seeking in either the sated or FDR groups.

CONCLUSIONS: The effect of food restriction on heroin seeking in female rats under withdrawal is as robust as previously found in males. Interestingly, estradiol replacement, but not progesterone, attenuates the food restriction effect in the ovariectomized rats, possibly due to its anorexic properties.

PMID: 26246318 [PubMed - indexed for MEDLINE]