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Energy loss associated with in-vitro modeling of mitral annular calcification.

Author(s): Wiener PC, Darwish A, Friend E, Kadem L, Pressman GS

INTRODUCTION: Study aims were to compare hemodynamics and viscous energy dissipation (VED) in 3D printed mitral valves-one replicating a normal valve and the other a valve with severe mitral annular calcification (MAC). Patients with severe MAC develop tran...

Article GUID: 33591991
Proper Orthogonal Decomposition Analysis of the Flow Downstream of a Dysfunctional Bileaflet Mechanical Aortic Valve.

Author(s): Darwish A, Di Labbio G, Saleh W, Kadem L

PURPOSE: Aortic valve replacement remains the only viable solution for symptomatic patients with severe aortic valve stenosis. Despite their improved design and long history of successful operation, bileaflet mechanical heart valves are still associated wit...

Article GUID: 33469847
Impact of Mitral Regurgitation on the Flow in a Model of a Left Ventricle.

Author(s): Papolla C, Darwish A, Kadem L, Rieu R

PURPOSE: Mitral regurgitation (MR) is the second most common valve disease in industrialized countries. Despite its high prevalence, little is known about its impact on the flow dynamics in the left ventricle (LV). Because of the interdependence between val...

Article GUID: 33000444
Experimental investigation of the flow downstream of a dysfunctional bileaflet mechanical aortic valve.

Author(s): Darwish A, Di Labbio G, Saleh W, Smadi O, Kadem L

Artif Organs. 2019 May 08;: Authors: Darwish A, Di Labbio G, Saleh W, Smadi O, Kadem L

Article GUID: 31066923
Title:Impact of Mitral Regurgitation on the Flow in a Model of a Left Ventricle.
Authors:Papolla C,  Darwish A,  Kadem L,  Rieu R
Link:https://www.ncbi.nlm.nih.gov/pubmed/33000444
DOI:10.1007/s13239-020-00490-y
Category:Cardiovasc Eng Technol
PMID:33000444
Dept Affiliation: ENCS
1 Aix-Marseille University, Gustave Eiffel University, LBA UMR_T 24, Marseille, France.
2 Képhalios, part of Affluent Medical Group, Aix-en-Provence, France.
3 Laboratory of Cardiovascular Fluid Dynamics, Mechanical, Industrial and Aerospace Engineering, Concordia University, Montréal, QC, Canada.
4 Aix-Marseille University, Gustave Eiffel University, LBA UMR_T 24, Marseille, France. regis.rieu@univ-amu.fr.
5 Laboratoire de Biomécanique Appliquée, Bd. P. Dramard, Faculté de Medecine secteur-Nord, 13916, Marseille Cedex 20, France. regis.rieu@univ-amu.fr.

Description:

Impact of Mitral Regurgitation on the Flow in a Model of a Left Ventricle.

Cardiovasc Eng Technol. 2020 Sep 30; :

Authors: Papolla C, Darwish A, Kadem L, Rieu R

Abstract

PURPOSE: Mitral regurgitation (MR) is the second most common valve disease in industrialized countries. Despite its high prevalence, little is known about its impact on the flow dynamics in the left ventricle (LV). Because of the interdependence between valvular function and hemodynamics in the heart chambers, an exploration of the dynamics in the LV could lead to a diagnosis of MR. This in vitro study aimed to develop an advanced left heart simulator capable of reproducing several conditions of MR and to evaluate their impact on the LV flow dynamics in terms of flow structures and viscous energy dissipation (VED).

METHODS: A simulator, previously developed to test mechanical and biological valves, was upgraded with an original anatomically-shaped mitral valve made from a hydrogel. The valve can be used in healthy or pathological configurations. The nature and severity of the disease was controlled by applying specific strain to the chordae. In this study, in addition to a healthy condition, two different severities of MR were investigated: moderate MR and severe MR. Planar time-resolved particle image velocimetry measurements were performed in order to evaluate the velocity field in the LV and the VED induced by each condition.

RESULTS: Our results showed that MR led to flow disturbances in the LV that were characterized by an increase in mitral inflow velocity and by elevated values of VED. Interestingly VED increased in proportion to the severity of MR and with a dissipation predominating during systole.

CONCLUSION: Considering these results, the introduction of new parameters based on LV VED could provide crucial information regarding the coupling between the mitral valve and the LV and allow for a better stratification of patients with MR.

PMID: 33000444 [PubMed - as supplied by publisher]