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Different methods of fear reduction are supported by distinct cortical substrates.

Author(s): Lay BP, Pitaru AA, Boulianne N, Esber GR, Iordanova MD

Elife. 2020 Jun 26;9: Authors: Lay BP, Pitaru AA, Boulianne N, Esber GR, Iordanova MD

Article GUID: 32589138
A self-initiated cue-reward learning procedure for neural recording in rodents.

Author(s): Reverte I, Volz S, Alhazmi FH, Kang M, Kaufman K, Chan S, Jou C, Iordanova MD, Esber GR

J Neurosci Methods. 2020 Mar 02;:108671 Authors: Reverte I, Volz S, Alhazmi FH, Kang M, Kaufman K, Chan S, Jou C, Iordanova MD, Esber GR

Article GUID: 32135212
Neural correlates of two different types of extinction learning in the amygdala central nucleus.

Author(s): Iordanova MD, Deroche ML, Esber GR, Schoenbaum G

Nat Commun. 2016 08 17;7:12330 Authors: Iordanova MD, Deroche ML, Esber GR, Schoenbaum G

Article GUID: 27531638
Dissociation of Appetitive Overexpectation and Extinction in the Infralimic Cortex.

Author(s): Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Cereb Cortex. 2018 Oct 29;: Authors: Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Article GUID: 30371757
Corrigendum: Dissociation of Appetitive Overexpectation and Extinction in the Infralimbic Cortex.

Author(s): Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Cereb Cortex. 2019 Apr 01;29(4):1703 Authors: Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD PMID: 30590441 [PubMed - in process]

Article GUID: 30590441
Title:Different methods of fear reduction are supported by distinct cortical substrates.
Authors:Lay BP,  Pitaru AA,  Boulianne N,  Esber GR,  Iordanova MD
Link:https://www.ncbi.nlm.nih.gov/pubmed/32589138?dopt=Abstract
DOI:10.7554/eLife.55294
Category:Elife
PMID:32589138
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioural Neurobiology, Department of Psychology, Concordia University, Montreal, Canada.
2 Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, United States.

Description:

Different methods of fear reduction are supported by distinct cortical substrates.

Elife. 2020 Jun 26;9:

Authors: Lay BP, Pitaru AA, Boulianne N, Esber GR, Iordanova MD

Abstract

Understanding how learned fear can be reduced is at the heart of treatments for anxiety disorders. Tremendous progress has been made in this regard through extinction training in which the aversive outcome is omitted. However, current progress almost entirely rests on this single paradigm, resulting in a very specialized knowledgebase at the behavioural and neural level of analysis. Here, we used a dual-paradigm approach to show that different methods that lead to reduction in learned fear in rats are dissociated in the cortex. We report that the infralimbic cortex has a very specific role in fear reduction that depends on the omission of aversive events but not on overexpectation. The orbitofrontal cortex, a structure generally overlooked in fear, is critical for downregulating fear when novel predictions about upcoming aversive events are generated, such as when fear is inflated or overexpected, but less so when an expected aversive event is omitted.

PMID: 32589138 [PubMed - as supplied by publisher]