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BOLD signal physiology: Models and applications.

Author(s): Gauthier CJ, Fan AP

Neuroimage. 2019 02 15;187:116-127 Authors: Gauthier CJ, Fan AP

Article GUID: 29544818
High resolution atlas of the venous brain vasculature from 7 T quantitative susceptibility maps.

Author(s): Huck J, Wanner Y, Fan AP, Jäger AT, Grahl S, Schneider U, Villringer A, Steele CJ, Tardif CL, Bazin PL, Gauthier CJ

Brain Struct Funct. 2019 Jul 05;: Authors: Huck J, Wanner Y, Fan AP, Jäger AT, Grahl S, Schneider U, Villringer A, Steele CJ, Tardif CL, Bazin PL, Gauthier CJ

Article GUID: 31278570
Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke.

Author(s): Fan AP, Khalil AA, Fiebach JB, Zaharchuk G, Villringer A, Villringer K, Gauthier CJ

J Cereb Blood Flow Metab. 2019 Feb 07;:271678X19827944 Authors: Fan AP, Khalil AA, Fiebach JB, Zaharchuk G, Villringer A, Villringer K, Gauthier CJ

Article GUID: 30732551
Title:BOLD signal physiology: Models and applications.
Authors:Gauthier CJ,  Fan AP
Link:https://www.ncbi.nlm.nih.gov/pubmed/29544818?dopt=Abstract
DOI:10.1016/j.neuroimage.2018.03.018
Category:Neuroimage
PMID:29544818
Dept Affiliation: IMAGING
1 Concordia University, Montreal, Canada. Electronic address: claudine.gauthier@concordia.ca.
2 Stanford University, California, USA.

Description:

BOLD signal physiology: Models and applications.

Neuroimage. 2019 02 15;187:116-127

Authors: Gauthier CJ, Fan AP

Abstract

The BOLD contrast mechanism has a complex relationship with functional brain activity, oxygen metabolism, and neurovascular factors. Accurate interpretation of the BOLD signal for neuroscience and clinical applications necessitates a clear understanding of the sources of BOLD contrast and its relationship to underlying physiology. This review describes the physiological components that contribute to the BOLD signal and the steady-state calibrated BOLD models that enable quantification of functional changes with a separate challenge paradigm. The principles derived from these biophysical models are then used to interpret BOLD measurements in different neurological disorders in the presence of confounding vascular factors related to disease.

PMID: 29544818 [PubMed - indexed for MEDLINE]