Keyword search (3,448 papers available)


Experimental study on pressure response to graded spinal canal compromise in an in vitro burst fracture mode.

Author(s): Bourget-Murray J, Bassi M, Frederick A, Hines J, Jarzem PF

J Craniovertebr Junction Spine. 2017 Apr-Jun;8(2):108-112 Authors: Bourget-Murray J, Bassi M, Frederick A, Hines J, Jarzem PF

Article GUID: 28694593
Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain.

Author(s): Frederick A, Goldsmith J, de Zavalia N, Amir S

PLoS One. 2017;12(4):e0176279 Authors: Frederick A, Goldsmith J, de Zavalia N, Amir S

Article GUID: 28423013
Diurnal influences on electrophysiological oscillations and coupling in the dorsal striatum and cerebellar cortex of the anesthetized rat.

Author(s): Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R

Front Syst Neurosci. 2014;8:145 Authors: Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R

Article GUID: 25309348
Title:Experimental study on pressure response to graded spinal canal compromise in an in vitro burst fracture mode.
Authors:Bourget-Murray J,  Bassi M,  Frederick A,  Hines J,  Jarzem PF
Link:https://www.ncbi.nlm.nih.gov/pubmed/28694593?dopt=Abstract
DOI:10.4103/jcvjs.JCVJS_25_17
Category:J Craniovertebr Junction Spine
PMID:28694593
Dept Affiliation: CSBN
1 McGill University Health Center, Orthopedic Research Laboratory, McGill University, Montreal, Canada.
2 Department of Orthopedic Surgery, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
3 Department of Orthopedic Surgery, Dr. Soliman Fakeeh Hospital, Jeddah, Saudi Arabia.
4 Center for Studies in Behavioural Neurobiology, Concordia University, Montreal, Canada.
5 Division of Orthopedic Surgery, McGill University, Montreal, Canada.

Description:

Experimental study on pressure response to graded spinal canal compromise in an in vitro burst fracture mode.

J Craniovertebr Junction Spine. 2017 Apr-Jun;8(2):108-112

Authors: Bourget-Murray J, Bassi M, Frederick A, Hines J, Jarzem PF

Abstract

BACKGROUND: Spinal cord compression is a known cause of spinal cord injury. The purpose of this study is to measure pressure response during graded spinal cord compression. This information will be important in evaluating the amount of canal compromise that can be tolerated before risking neurological injury secondary to cord compression. To date, there is no published study that has evaluated pressure response to graded canal compromise in the thoracic and lumbar spine.

MATERIALS AND METHODS: A comparative biomechanical investigation using an in vitro burst fracture model of graded spinal canal compromise was performed. Four porcine spines, sectioned into four thoracics and four lumbar segments, were harvested from 30 kg pigs. Graded spinal canal compromise (0.75 mm/30 s) was achieved using a modified 12.7 mm dynamic hip screw. The real-time ventral epidural pressure was measured at each 0.75 mm of canal compromise.

RESULTS: A significant increase in spinal cord pressure was recorded during graded spinal cord compression (P < 0.0001), and there were no statistical differences between the increase in pressure measured in the thoracic and lumbar spinal segments (P = 0.83). The pressure to degree of canal compromise curve exhibited an initial rapid rise in pressure followed by incrementally smaller increases in pressure as canal compromise increased.

CONCLUSIONS: Spinal cord pressure increased with any degree of canal compromise, the most important rise occurring with initial compression. Future studies will evaluate the usefulness of laminectomy in vivo to completely restore ventral epidural pressure in the thoracic and lumbar spine.

PMID: 28694593 [PubMed]