Keyword search (3,448 papers available)


Re-stepping into the same river: competition problem rather than a reconsolidation failure in an established motor skill.

Author(s): Gabitov E, Boutin A, Pinsard B, Censor N, Fogel SM, Albouy G, King BR, Benali H, Carrier J, Cohen LG, Karni A, Doyon J

Sci Rep. 2017 08 24;7(1):9406 Authors: Gabitov E, Boutin A, Pinsard B, Censor N, Fogel SM, Albouy G, King BR, Benali H, Carrier J, Cohen LG, Karni A, Doyon J

Article GUID: 28839217
Consolidation alters motor sequence-specific distributed representations.

Author(s): Pinsard B, Boutin A, Gabitov E, Lungu O, Benali H, Doyon J

Elife. 2019 Mar 18;8: Authors: Pinsard B, Boutin A, Gabitov E, Lungu O, Benali H, Doyon J

Article GUID: 30882348
Title:Consolidation alters motor sequence-specific distributed representations.
Authors:Pinsard B,  Boutin A,  Gabitov E,  Lungu O,  Benali H,  Doyon J
Link:https://www.ncbi.nlm.nih.gov/pubmed/30882348?dopt=Abstract
DOI:10.7554/eLife.39324
Category:Elife
PMID:30882348
Dept Affiliation: PERFORM
1 Laboratoire d'Imagerie Biomédicale, Sorbonne Université, CNRS, INSERM, Paris, France.
2 Functional Neuroimaging Unit, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montreal, Canada.
3 McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada.
4 PERFORM Centre, Concordia University, Montreal, Canada.
5 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.

Description:

Consolidation alters motor sequence-specific distributed representations.

Elife. 2019 Mar 18;8:

Authors: Pinsard B, Boutin A, Gabitov E, Lungu O, Benali H, Doyon J

Abstract

Functional magnetic resonance imaging (fMRI) studies investigating the acquisition of sequential motor skills in humans have revealed learning-related functional reorganizations of the cortico-striatal and cortico-cerebellar motor systems accompanied with an initial hippocampal contribution. Yet, the functional significance of these activity-level changes remains ambiguous as they convey the evolution of both sequence-specific knowledge and unspecific task ability. Moreover, these changes do not specifically assess the occurrence of learning-related plasticity. To address these issues, we investigated local circuits tuning to sequence-specific information using multivariate distances between patterns evoked by consolidated or newly acquired motor sequences production. The results reveal that representations in dorsolateral striatum, prefrontal and secondary motor cortices are greater when executing consolidated sequences than untrained ones. By contrast, sequence representations in the hippocampus and dorsomedial striatum becomes less engaged. Our findings show, for the first time in humans, that complementary sequence-specific motor representations evolve distinctively during critical phases of skill acquisition and consolidation.

PMID: 30882348 [PubMed - in process]