Keyword search (3,619 papers available)


Recommendations of the 5th Canadian Consensus Conference on the diagnosis and treatment of dementia.

Author(s): Ismail Z, Black SE, Camicioli R, Chertkow H, Herrmann N, Laforce R, Montero-Odasso M, Rockwood K, Rosa-Neto P, Seitz D, Sivananthan S, Smith...

Alzheimers Dement. 2020 Jul 29;: Authors: Ismail Z, Black SE, Camicioli R, Chertkow H, Herrmann N, Laforce R, Montero-Odasso M, Rockwood K, Rosa-Neto P, Seitz D, Sivananthan S, Smith EE, Soucy JP,...

Article GUID: 32725777
Topographical distribution of Aβ predicts progression to dementia in Aβ positive mild cognitive impairment

Author(s): Pascoal TA, Therriault J, Mathotaarachchi S, Kang MS, Shin M, Benedet AL, Chamoun M, Tissot C, Lussier F, Mohaddes S, Soucy JP, Massarweh G,...

INTRODUCTION: Abnormal brain amyloid beta (Aβ) is typically assessed in vivo using global concentrations from cerebrospinal fluid and positron emission tomography (PET). However, it is unknown...

Article GUID: 32582834
Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease.

Author(s): Hadoux X, Hui F, Lim JKH, Masters CL, Pébay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Les...

Nat Commun. 2019 Sep 17;10(1):4227 Authors: Hadoux X, Hui F, Lim JKH, Masters CL, Pébay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Lesage F, ...

Article GUID: 31530809
The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study.

Author(s): Chertkow H, Borrie M, Whitehead V, Black SE, Feldman HH, Gauthier S, Hogan DB, Masellis M, McGilton K, Rockwood K, Tierney MC, Andrew M, Hsi...

Can J Neurol Sci. 2019 Jul 16;:1-13 Authors: Chertkow H, Borrie M, Whitehead V, Black SE, Feldman HH, Gauthier S, Hogan DB, Masellis M, McGilton K, Rockwood K, Tierney MC, Andrew M, Hsiung GR, Cam...

Article GUID: 31309917
Brain perfusion during rapid-eye-movement sleep successfully identifies amnestic mild cognitive impairment.

Author(s): Brayet P, Petit D, Baril AA, Gosselin N, Gagnon JF, Soucy JP, Gauthier S, Kergoat MJ, Carrier J, Rouleau I, Montplaisir J

Sleep Med. 2017 Jun;34:134-140 Authors: Brayet P, Petit D, Baril AA, Gosselin N, Gagnon JF, Soucy JP, Gauthier S, Kergoat MJ, Carrier J, Rouleau I, Montplaisir J

Article GUID: 28522082
Quantification of brain cholinergic denervation in Alzheimer's disease using PET imaging with [18F]-FEOBV.

Author(s): Aghourian M, Legault-Denis C, Soucy JP, Rosa-Neto P, Gauthier S, Kostikov A, Gravel P, Bédard MA

Mol Psychiatry. 2017 11;22(11):1531-1538 Authors: Aghourian M, Legault-Denis C, Soucy JP, Rosa-Neto P, Gauthier S, Kostikov A, Gravel P, Bédard MA

Article GUID: 28894304
Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease.

Author(s): Pascoal TA, Mathotaarachchi S, Shin M, Park AY, Mohades S, Benedet AL, Kang MS, Massarweh G, Soucy JP, Gauthier S, Rosa-Neto P, Alzheimer’s ...

Eur J Nucl Med Mol Imaging. 2018 06;45(6):1021-1030 Authors: Pascoal TA, Mathotaarachchi S, Shin M, Park AY, Mohades S, Benedet AL, Kang MS, Massarweh G, Soucy JP, Gauthier S, Rosa-Neto P, Alzheim...

Article GUID: 29396637
Title:The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study.
Authors:Chertkow H,  Borrie M,  Whitehead V,  Black SE,  Feldman HH,  Gauthier S,  Hogan DB,  Masellis M,  McGilton K,  Rockwood K,  Tierney MC,  Andrew M,  Hsiung GR,  Camicioli R,  Smith EE,  Fogarty J,  Lindsay J,  Best S,  Evans A,  Das S,  Mohaddes Z,  Pilon R,  Poirier J,  Phillips NA,  MacNamara E,  Dixon RA,  Duchesne S,  MacKenzie I,  Rylett RJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/31309917?dopt=Abstract
DOI:10.1017/cjn.2019.27
Category:Can J Neurol Sci
PMID:31309917
Dept Affiliation: PSYCHOLOGY
1 Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
2 Lady Davis Institute, Montreal, Quebec, Canada.
3 Department of Geriatric Medicine, Western University, London, Ontario, Canada.
4 Lawson Health Research Institute, London, Ontario, Canada.
5 Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
6 Sunnybrook Research Institute, Toronto, Ontario, Canada.
7 Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
8 Department of Neurosciences, University of California, San Diego, California, USA.
9 The Hotchkiss Brain Institute, Calgary, Alberta, Canada.
10 Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
11 McGill Center for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
12 Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
13 Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada.
14 Toronto Rehabilitation Institute, Toronto, Ontario, Canada.
15 Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
16 Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.
17 Department of Physiology and Pharmacology, Western University, London, Ontario, Canada.
18 Robarts Research, London, Ontario, Canada.
19 Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
20 Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
21 Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada.
22 Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
23 Department of Psychiatry, Western University, London, Ontario, Canada.
24 McConnell Brain Imaging Centre, McGill University, Montreal, Quebec, Canada.
25 McGill Centre for Integrative Neuroscience, Montreal, Quebec, Canada.
26 Department of Psychology, Concordia University, Montreal, Quebec, Canada.
27 Department of Medicine, McGill University, Montreal, Quebec, Canada.
28 Department of Psychology, University of Alberta, Edmonton, Alberta, Canada.
29 Department of Radiology, Laval University, Quebec City, Quebec, Canada.
30 Centre de recherche de l'Institut universitaire en santé mentale de Québec, Université Laval, Québec City, Québec, Canada.
31 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Description:

The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study.

Can J Neurol Sci. 2019 Jul 16;:1-13

Authors: Chertkow H, Borrie M, Whitehead V, Black SE, Feldman HH, Gauthier S, Hogan DB, Masellis M, McGilton K, Rockwood K, Tierney MC, Andrew M, Hsiung GR, Camicioli R, Smith EE, Fogarty J, Lindsay J, Best S, Evans A, Das S, Mohaddes Z, Pilon R, Poirier J, Phillips NA, MacNamara E, Dixon RA, Duchesne S, MacKenzie I, Rylett RJ

Abstract

BACKGROUND: The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) cohort study of the Canadian Consortium on Neurodegeneration in Aging (CCNA) is a national initiative to catalyze research on dementia, set up to support the research agendas of CCNA teams. This cross-country longitudinal cohort of 2310 deeply phenotyped subjects with various forms of dementia and mild memory loss or concerns, along with cognitively intact elderly subjects, will test hypotheses generated by these teams.

METHODS: The COMPASS-ND protocol, initial grant proposal for funding, fifth semi-annual CCNA Progress Report submitted to the Canadian Institutes of Health Research December 2017, and other documents supplemented by modifications made and lessons learned after implementation were used by the authors to create the description of the study provided here.

RESULTS: The CCNA COMPASS-ND cohort includes participants from across Canada with various cognitive conditions associated with or at risk of neurodegenerative diseases. They will undergo a wide range of experimental, clinical, imaging, and genetic investigation to specifically address the causes, diagnosis, treatment, and prevention of these conditions in the aging population. Data derived from clinical and cognitive assessments, biospecimens, brain imaging, genetics, and brain donations will be used to test hypotheses generated by CCNA research teams and other Canadian researchers. The study is the most comprehensive and ambitious Canadian study of dementia. Initial data posting occurred in 2018, with the full cohort to be accrued by 2020.

CONCLUSION: Availability of data from the COMPASS-ND study will provide a major stimulus for dementia research in Canada in the coming years.

PMID: 31309917 [PubMed - as supplied by publisher]