Keyword search (3,447 papers available)


Detection of abnormal resting-state networks in individual patients suffering from focal epilepsy: an initial step toward individual connectivity assessment.

Author(s): Dansereau CL, Bellec P, Lee K, Pittau F, Gotman J, Grova C

Front Neurosci. 2014;8:419 Authors: Dansereau CL, Bellec P, Lee K, Pittau F, Gotman J, Grova C

Article GUID: 25565949
Detection and Magnetic Source Imaging of Fast Oscillations (40-160 Hz) Recorded with Magnetoencephalography in Focal Epilepsy Patients.

Author(s): von Ellenrieder N, Pellegrino G, Hedrich T, Gotman J, Lina JM, Grova C, Kobayashi E

Brain Topogr. 2016 Mar;29(2):218-31 Authors: von Ellenrieder N, Pellegrino G, Hedrich T, Gotman J, Lina JM, Grova C, Kobayashi E

Article GUID: 26830767
SPARK: Sparsity-based analysis of reliable k-hubness and overlapping network structure in brain functional connectivity.

Author(s): Lee K, Lina JM, Gotman J, Grova C

Neuroimage. 2016 07 01;134:434-449 Authors: Lee K, Lina JM, Gotman J, Grova C

Article GUID: 27046111
Disruption, emergence and lateralization of brain network hubs in mesial temporal lobe epilepsy.

Author(s): Lee K, Khoo HM, Lina JM, Dubeau F, Gotman J, Grova C

Neuroimage Clin. 2018;20:71-84 Authors: Lee K, Khoo HM, Lina JM, Dubeau F, Gotman J, Grova C

Article GUID: 30094158
Automatic classification and removal of structured physiological noise for resting state functional connectivity MRI analysis.

Author(s): Lee K, Khoo HM, Fourcade C, Gotman J, Grova C

Magn Reson Imaging. 2019 05;58:97-107 Authors: Lee K, Khoo HM, Fourcade C, Gotman J, Grova C

Article GUID: 30695721
Title:SPARK: Sparsity-based analysis of reliable k-hubness and overlapping network structure in brain functional connectivity.
Authors:Lee K,  Lina JM,  Gotman J,  Grova C
Link:https://www.ncbi.nlm.nih.gov/pubmed/27046111?dopt=Abstract
DOI:10.1016/j.neuroimage.2016.03.049
Category:Neuroimage
PMID:27046111
Dept Affiliation: PERFORM
1 Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University, Duff Medical Building, 3775 Rue University, Montreal, QC H3A 2B4, Canada; Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada. Electronic address: kangjoo.lee@mail.mcgill.ca.
2 École de Technologie Supérieure, 1100 Rue Notre-Dame O, Montreal, QC H3C 1K3, Canada; Centre de Recherches Mathématiques, Université de Montréal, Pavillon André-Aisenstadt 2920 Chemin de la tour, Room 5357, Montreal, QC H3T 1J4, Canada.
3 Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada.
4 Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University, Duff Medical Building, 3775 Rue University, Montreal, QC H3A 2B4, Canada; Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada; Centre de Recherches Mathématiques, Université de Montréal, Pavillon André-Aisenstadt 2920 Chemin de la tour, Room 5357, Montreal, QC H3T 1J4, Canada; Physics Department and PERFORM Centre, Concordia University, 7200 Rue Sherbrooke St. W, Montreal, QC H4B 1R6, Canada.

Description:

SPARK: Sparsity-based analysis of reliable k-hubness and overlapping network structure in brain functional connectivity.

Neuroimage. 2016 07 01;134:434-449

Authors: Lee K, Lina JM, Gotman J, Grova C

Abstract

Functional hubs are defined as the specific brain regions with dense connections to other regions in a functional brain network. Among them, connector hubs are of great interests, as they are assumed to promote global and hierarchical communications between functionally specialized networks. Damage to connector hubs may have a more crucial effect on the system than does damage to other hubs. Hubs in graph theory are often identified from a correlation matrix, and classified as connector hubs when the hubs are more connected to regions in other networks than within the networks to which they belong. However, the identification of hubs from functional data is more complex than that from structural data, notably because of the inherent problem of multicollinearity between temporal dynamics within a functional network. In this context, we developed and validated a method to reliably identify connectors and corresponding overlapping network structure from resting-state fMRI. This new method is actually handling the multicollinearity issue, since it does not rely on counting the number of connections from a thresholded correlation matrix. The novelty of the proposed method is that besides counting the number of networks involved in each voxel, it allows us to identify which networks are actually involved in each voxel, using a data-driven sparse general linear model in order to identify brain regions involved in more than one network. Moreover, we added a bootstrap resampling strategy to assess statistically the reproducibility of our results at the single subject level. The unified framework is called SPARK, i.e. SParsity-based Analysis of Reliable k-hubness, where k-hubness denotes the number of networks overlapping in each voxel. The accuracy and robustness of SPARK were evaluated using two dimensional box simulations and realistic simulations that examined detection of artificial hubs generated on real data. Then, test/retest reliability of the method was assessed using the 1000 Functional Connectome Project database, which includes data obtained from 25 healthy subjects at three different occasions with long and short intervals between sessions. We demonstrated that SPARK provides an accurate and reliable estimation of k-hubness, suggesting a promising tool for understanding hub organization in resting-state fMRI.

PMID: 27046111 [PubMed - indexed for MEDLINE]