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Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner.

Author(s): Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A

Horm Behav. 2018 01;97:56-66 Authors: Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A

Article GUID: 29080670
Infusions of ascorbic acid into the medial preoptic area facilitate appetitive sexual behavior in the female rat.

Author(s): Graham MD, Pfaus JG

Physiol Behav. 2013 Oct 02;122:140-6 Authors: Graham MD, Pfaus JG

Article GUID: 24064109
Glutamate release in the ventromedial hypothalamus of the female rat during copulation: modulation by estradiol.

Author(s): Georgescu M, Afonso VM, Graham MD, Pfaus JG

Horm Behav. 2014 Feb;65(2):119-26 Authors: Georgescu M, Afonso VM, Graham MD, Pfaus JG

Article GUID: 24333845
Vaginocervical stimulation attenuates the sensitization of appetitive sexual behaviors by estradiol benzoate in the ovariectomized rat.

Author(s): Jones SL, Germé K, Graham MD, Roy P, Gardner Gregory J, Rosenbaum S, Parada M, Pfaus JG

Horm Behav. 2015 Sep;75:70-7 Authors: Jones SL, Germé K, Graham MD, Roy P, Gardner Gregory J, Rosenbaum S, Parada M, Pfaus JG

Article GUID: 26278846
Ovarian steroids alter dopamine receptor populations in the medial preoptic area of female rats: implications for sexual motivation, desire, and behaviour.

Author(s): Graham MD, Gardner Gregory J, Hussain D, Brake WG, Pfaus JG

Eur J Neurosci. 2015 Dec;42(12):3138-48 Authors: Graham MD, Gardner Gregory J, Hussain D, Brake WG, Pfaus JG

Article GUID: 26536143
Title:Infusions of ascorbic acid into the medial preoptic area facilitate appetitive sexual behavior in the female rat.
Authors:Graham MD,  Pfaus JG
Link:https://www.ncbi.nlm.nih.gov/pubmed/24064109?dopt=Abstract
Category:Physiol Behav
PMID:24064109
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC H4B 1R6, Canada.

Description:

Infusions of ascorbic acid into the medial preoptic area facilitate appetitive sexual behavior in the female rat.

Physiol Behav. 2013 Oct 02;122:140-6

Authors: Graham MD, Pfaus JG

Abstract

Ascorbic acid (AA), also known as Vitamin C, enhances dopamine (DA) transmission in mesolimbic and nigrostriatal terminals and augments DA-mediated behaviors. It is not yet known whether AA has a similar influence in other DA terminals, in particular terminals of the incertohypothalamic system that modulate the function of the medial preoptic area (mPOA). In female rats, DA in the mPOA plays a critical role in the generation of appetitive sexual responses, notably solicitations, hops, and darts, and we have shown previously that the role of DA in this region on female sexual behavior changes depending on the hormonal profile of the female. Since AA has often been used as a vehicle control in the examination of rat sexual behavior, the present study examined the effect of infusions of AA to the mPOA of sexual experienced ovariectomized rats under two hormonal conditions: partially-primed with estradiol benzoate (EB) alone or fully-primed with EB and progesterone. Relative to saline baselines, females under both hormonal conditions displayed a significant increase in appetitive sexual behaviors following infusions of AA. No difference in lordosis behavior was observed following AA infusions relative to saline baselines. We suggest that the mechanism by which AA infusions to the mPOA increase appetitive sexual behaviors in female rats may be through dose-dependent DA receptor interactions, possibly through both presynaptic release mechanisms and postsynaptic DA D1-related messenger systems.

PMID: 24064109 [PubMed - indexed for MEDLINE]