Keyword search (3,619 papers available)


Cocaine cue-induced dopamine release in the human prefrontal cortex.

Author(s): Milella MS, Fotros A, Gravel P, Casey KF, Larcher K, Verhaeghe JA, Cox SM, Reader AJ, Dagher A, Benkelfat C, Leyton M

J Psychiatry Neurosci. 2016 08;41(5):322-30 Authors: Milella MS, Fotros A, Gravel P, Casey KF, Larcher K, Verhaeghe JA, Cox SM, Reader AJ, Dagher A, Benkelfat C, Leyton M

Article GUID: 26900792
Posterior dopamine D2/3 receptors and brain network functional connectivity.

Author(s): Nagano-Saito A, Lissemore JI, Gravel P, Leyton M, Carbonell F, Benkelfat C

Synapse. 2017 11;71(11): Authors: Nagano-Saito A, Lissemore JI, Gravel P, Leyton M, Carbonell F, Benkelfat C

Article GUID: 28700819
Quantification of brain cholinergic denervation in Alzheimer's disease using PET imaging with [18F]-FEOBV.

Author(s): Aghourian M, Legault-Denis C, Soucy JP, Rosa-Neto P, Gauthier S, Kostikov A, Gravel P, Bédard MA

Mol Psychiatry. 2017 11;22(11):1531-1538 Authors: Aghourian M, Legault-Denis C, Soucy JP, Rosa-Neto P, Gauthier S, Kostikov A, Gravel P, Bédard MA

Article GUID: 28894304
Altered Regional Cerebral Blood Flow in Idiopathic Hypersomnia.

Author(s): Boucetta S, Montplaisir J, Zadra A, Lachapelle F, Soucy JP, Gravel P, Dang-Vu TT

Sleep. 2017 10 01;40(10): Authors: Boucetta S, Montplaisir J, Zadra A, Lachapelle F, Soucy JP, Gravel P, Dang-Vu TT

Article GUID: 28958044
Title:Posterior dopamine D2/3 receptors and brain network functional connectivity.
Authors:Nagano-Saito A,  Lissemore JI,  Gravel P,  Leyton M,  Carbonell F,  Benkelfat C
Link:https://www.ncbi.nlm.nih.gov/pubmed/28700819?dopt=Abstract
DOI:10.1002/syn.21993
Category:Synapse
PMID:28700819
Dept Affiliation: PERFORM
1 Department of Psychiatry, McGill University, Montreal, Quebec, H3A 1A1, Canada.
2 Department of Neurology and Neurosurgery, McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 1A1, Canada.
3 PERFORM Centre, Concordia University, Montreal, Quebec, H4B 1R6, Canada.
4 Biospective Inc., Montreal, QC, H3B 2T9, Canada.

Description:

Posterior dopamine D2/3 receptors and brain network functional connectivity.

Synapse. 2017 11;71(11):

Authors: Nagano-Saito A, Lissemore JI, Gravel P, Leyton M, Carbonell F, Benkelfat C

Abstract

Recent studies suggest that dopaminergic tone influences resting state activity in multiple brain networks. Although dopamine receptors and transporters have been identified in the posteromedial and parietal cortices, which are linked to functional networks such as the default mode network (DMN), the relationship between dopamine receptor distribution in these posterior regions and resting-state connectivity has yet to be explored. Here, we used a multi-modal neuroimaging strategy, combining resting-state functional magnetic resonance imaging (rsfMRI) and [18 F]-fallypride high-resolution positron emission tomography (PET), to examine the association between within-network functional connectivity and the dopamine D2/3 receptor distribution in the posterior portion of the brain in 13 healthy adults. Our results indicate that the posterior distribution of D2/3 receptors coincides primarily with the posterior portion of the DMN. Furthermore, in the posterior portion of the brain, the level of [18 F]-fallypride binding in the posteromedial cortex correlated positively with the functional connectivity strength of the DMN and sensorimotor network, and negatively with the functional connectivity strength of the dorsal attention network, the salience network, and a network that included the anterior part of the temporo-parietal junction. On the basis of these findings, we propose that posterior brain dopamine influences the configuration of the posterior DMN and several other functional brain networks. The posterior distribution of D2/3 receptors binding (hot colour spectrum) coincides with the functional connectivity of the posterior portion of the default mode network (green colour spectrum). The mean BPND in a posteromedial cortex and the mean ICA-Z score in the precuneus showed significant positive correlation.

PMID: 28700819 [PubMed - indexed for MEDLINE]