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Ventral Midbrain NMDA Receptor Blockade: From Enhanced Reward and Dopamine Inactivation.

Author(s): Hernandez G, Cossette MP, Shizgal P, Rompré PP

Front Behav Neurosci. 2016;10:161 Authors: Hernandez G, Cossette MP, Shizgal P, Rompré PP

Article GUID: 27616984
Endocannabinoids promote cocaine-induced impulsivity and its rapid dopaminergic correlates.

Author(s): Hernandez G, Oleson EB, Gentry RN, Abbas Z, Bernstein DL, Arvanitogiannis A, Cheer JF

Biol Psychiatry. 2014 Mar 15;75(6):487-98 Authors: Hernandez G, Oleson EB, Gentry RN, Abbas Z, Bernstein DL, Arvanitogiannis A, Cheer JF

Article GUID: 24138924
Adolescent Exposure to Methylphenidate Increases Impulsive Choice Later in Life.

Author(s): Abbas Z, Sweet A, Hernandez G, Arvanitogiannis A

Front Behav Neurosci. 2017;11:214 Authors: Abbas Z, Sweet A, Hernandez G, Arvanitogiannis A

Article GUID: 29163086
Title:Endocannabinoids promote cocaine-induced impulsivity and its rapid dopaminergic correlates.
Authors:Hernandez G,  Oleson EB,  Gentry RN,  Abbas Z,  Bernstein DL,  Arvanitogiannis A,  Cheer JF
Link:https://www.ncbi.nlm.nih.gov/pubmed/24138924?dopt=Abstract
Category:Biol Psychiatry
PMID:24138924
Dept Affiliation: CSBN
1 Department of Physiology, Université de Montréal, Montréal, Quebec, Canada.
2 Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland.
3 Center for Studies in Behavioral Neurobiology, Concordia University, Montréal, Quebec, Canada.
4 Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address: jchee001@umaryland.edu.

Description:

Endocannabinoids promote cocaine-induced impulsivity and its rapid dopaminergic correlates.

Biol Psychiatry. 2014 Mar 15;75(6):487-98

Authors: Hernandez G, Oleson EB, Gentry RN, Abbas Z, Bernstein DL, Arvanitogiannis A, Cheer JF

Abstract

BACKGROUND: Impaired decision making, a hallmark of addiction, is hypothesized to arise from maladaptive plasticity in the mesolimbic dopamine pathway. The endocannabinoid system modulates dopamine activity through activation of cannabinoid type 1 receptors (CB1Rs). Here, we investigated whether impulsive behavior observed following cocaine exposure requires CB1R activation.

METHODS: We trained rats in a delay-discounting task. Following acquisition of stable performance, rats were exposed to cocaine (10 mg/kg, intraperitoneal) every other day for 14 days and locomotor activity was measured. Two days later, delay-discounting performance was re-evaluated. To assess reversal of impulsivity, injections of a CB1R antagonist (1.5 mg/kg, intraperitoneal) or vehicle were given 30 minutes before the task. During the second experiment, aimed at preventing impulsivity rather than reversing it, CB1Rs were antagonized before each cocaine injection. In this experiment, subsecond dopamine release was measured in the nucleus accumbens during delay-discounting sessions before and after cocaine treatment.

RESULTS: Blockade of CB1Rs reversed and prevented cocaine-induced impulsivity. Electrochemical results showed that during baseline and following disruption of endocannabinoid signaling, there was a robust increase in dopamine for immediate large rewards compared with immediate small rewards, but this effect reversed when the delay for the large reward was 10 seconds. In contrast, dopamine release always increased for one-pellet options at minimal or moderate delays in vehicle-treated rats.

CONCLUSIONS: Endocannabinoids play a critical role in changes associated with cocaine exposure. Cannabinoid type 1 receptor blockade may thus counteract maladaptive alterations in afferents to dopamine neurons, thereby preventing changes in dopaminergic activity underlying a loss of self-control.

PMID: 24138924 [PubMed - indexed for MEDLINE]