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Daytime cortisol and stress reactivity in the offspring of parents with bipolar disorder.

Author(s): Ellenbogen MA, Hodgins S, Walker CD, Couture S, Adam S

Psychoneuroendocrinology. 2006 Nov;31(10):1164-80 Authors: Ellenbogen MA, Hodgins S, Walker CD, Couture S, Adam S

Article GUID: 17055665
Chronic stress and stressful life events in the offspring of parents with bipolar disorder.

Author(s): Ostiguy CS, Ellenbogen MA, Linnen AM, Walker EF, Hammen C, Hodgins S

J Affect Disord. 2009 Apr;114(1-3):74-84 Authors: Ostiguy CS, Ellenbogen MA, Linnen AM, Walker EF, Hammen C, Hodgins S

Article GUID: 18814916
Structure provided by parents in middle childhood predicts cortisol reactivity in adolescence among the offspring of parents with bipolar disorder and controls.

Author(s): Ellenbogen MA, Hodgins S

Psychoneuroendocrinology. 2009 Jun;34(5):773-85 Authors: Ellenbogen MA, Hodgins S

Article GUID: 19193493
High cortisol levels in the offspring of parents with bipolar disorder during two weeks of daily sampling.

Author(s): Ellenbogen MA, Santo JB, Linnen AM, Walker CD, Hodgins S

Bipolar Disord. 2010 Feb;12(1):77-86 Authors: Ellenbogen MA, Santo JB, Linnen AM, Walker CD, Hodgins S

Article GUID: 20148869
Elevated daytime cortisol levels: a biomarker of subsequent major affective disorder?

Author(s): Ellenbogen MA, Hodgins S, Linnen AM, Ostiguy CS

J Affect Disord. 2011 Jul;132(1-2):265-9 Authors: Ellenbogen MA, Hodgins S, Linnen AM, Ostiguy CS

Article GUID: 21329985
Sensitivity to stress among the offspring of parents with bipolar disorder: a study of daytime cortisol levels.

Author(s): Ostiguy CS, Ellenbogen MA, Walker CD, Walker EF, Hodgins S

Psychol Med. 2011 Nov;41(11):2447-57 Authors: Ostiguy CS, Ellenbogen MA, Walker CD, Walker EF, Hodgins S

Article GUID: 21524333
Salivary cortisol and interpersonal functioning: an event-contingent recording study in the offspring of parents with bipolar disorder.

Author(s): Ellenbogen MA, Linnen AM, Santo JB, aan het Rot M, Hodgins S, Young SN

Psychoneuroendocrinology. 2013 Jul;38(7):997-1006 Authors: Ellenbogen MA, Linnen AM, Santo JB, aan het Rot M, Hodgins S, Young SN

Article GUID: 23131593
Personality, coping, risky behavior, and mental disorders in the offspring of parents with bipolar disorder: a comprehensive psychosocial assessment.

Author(s): Nijjar R, Ellenbogen MA, Hodgins S

J Affect Disord. 2014 Sep;166:315-23 Authors: Nijjar R, Ellenbogen MA, Hodgins S

Article GUID: 25012447
Sexual Risk Behaviors in the Adolescent Offspring of Parents with Bipolar Disorder: Prospective Associations with Parents' Personality and Externalizing Behavior in Childhood.

Author(s): Nijjar R, Ellenbogen MA, Hodgins S

J Abnorm Child Psychol. 2016 10;44(7):1347-59 Authors: Nijjar R, Ellenbogen MA, Hodgins S

Article GUID: 26767833
Title:Elevated daytime cortisol levels: a biomarker of subsequent major affective disorder?
Authors:Ellenbogen MA,  Hodgins S,  Linnen AM,  Ostiguy CS
Link:https://www.ncbi.nlm.nih.gov/pubmed/21329985?dopt=Abstract
Category:J Affect Disord
PMID:21329985
Dept Affiliation: CRDH
1 Centre for Research in Human Development, Concordia University, Montréal (Québec), Canada. mark.ellenbogen@concordia.ca

Description:

Elevated daytime cortisol levels: a biomarker of subsequent major affective disorder?

J Affect Disord. 2011 Jul;132(1-2):265-9

Authors: Ellenbogen MA, Hodgins S, Linnen AM, Ostiguy CS

Abstract

BACKGROUND: Several studies have reported that the offspring of parents with affective disorders secrete high levels of daytime cortisol. A few studies have shown that high cortisol levels preceded the onset of affective symptoms. Only one study to date has found that an elevation in cortisol preceded the onset of an affective disorder, but this was observed only in those youth carrying the short allele of the serotonin transporter gene promoter polymorphism (Goodyer et al., 2009).

METHODS: We followed 28 offspring of parents with bipolar disorder and 31 offspring of parents with no affective disorder from an average age of 17.5years to an average age of 20.0years to determine if cortisol levels at baseline predicted the subsequent development of an affective disorder. At baseline and at follow-up participants completed a diagnostic assessment, and at baseline they provided saliva samples. Daytime cortisol levels were computed as the mean of eight to 24 samples measured across two to six days.

RESULTS: Among the 59 participants, cortisol levels at the mean age of 17.5years predicted the development of an affective disorder during the subsequent 2.5year (odds ratio: 2.1, 95% confidence interval=1.0-4.1, p<0.05) after controlling for offspring mental disorders at the first assessment and having a parent with bipolar disorder.

LIMITATIONS: The findings should be interpreted with caution, as the sample size was small.

CONCLUSION: Elevated daytime cortisol levels in late adolescence may be a biomarker of vulnerability for affective disorders.

PMID: 21329985 [PubMed - indexed for MEDLINE]