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Higher cardiovascular fitness level is associated with lower cerebrovascular reactivity and perfusion in healthy older adults.

Author(s): Intzandt B, Sabra D, Foster C, Desjardins-Crépeau L, Hoge RD, Steele CJ, Bherer L, Gauthier CJ

J Cereb Blood Flow Metab. 2019 Jul 25;:271678X19862873 Authors: Intzandt B, Sabra D, Foster C, Desjardins-Crépeau L, Hoge RD, Steele CJ, Bherer L, Gauthier CJ

Article GUID: 31342831
Higher levels of cardiovascular fitness are associated with better executive function and prefrontal oxygenation in younger and older women.

Author(s): Dupuy O, Gauthier CJ, Fraser SA, Desjardins-Crèpeau L, Desjardins M, Mekary S, Lesage F, Hoge RD, Pouliot P, Bherer L

Front Hum Neurosci. 2015;9:66 Authors: Dupuy O, Gauthier CJ, Fraser SA, Desjardins-Crèpeau L, Desjardins M, Mekary S, Lesage F, Hoge RD, Pouliot P, Bherer L

Article GUID: 25741267
Age differences in brain signal variability are robust to multiple vascular controls.

Author(s): Garrett DD, Lindenberger U, Hoge RD, Gauthier CJ

Sci Rep. 2017 08 31;7(1):10149 Authors: Garrett DD, Lindenberger U, Hoge RD, Gauthier CJ

Article GUID: 28860455
Title:Age differences in brain signal variability are robust to multiple vascular controls.
Authors:Garrett DD,  Lindenberger U,  Hoge RD,  Gauthier CJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/28860455?dopt=Abstract
DOI:10.1038/s41598-017-09752-7
Category:Sci Rep
PMID:28860455
Dept Affiliation: PERFORM
1 Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin/London, Germany. garrett@mpib-berlin.mpg.de.
2 Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany. garrett@mpib-berlin.mpg.de.
3 Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin/London, Germany.
4 Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
5 European University Institute, San Domenico di Fiesole (FI), Fiesole, Italy.
6 Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
7 Department of Physics, Concordia University, Montreal, Canada.
8 PERFORM Centre, Concordia University, Montreal, Canada.

Description:

Age differences in brain signal variability are robust to multiple vascular controls.

Sci Rep. 2017 08 31;7(1):10149

Authors: Garrett DD, Lindenberger U, Hoge RD, Gauthier CJ

Abstract

A host of studies support that younger, better performing adults express greater moment-to-moment blood oxygen level-dependent (BOLD) signal variability (SDBOLD) in various cortical regions, supporting an emerging view that the aging brain may undergo a generalized reduction in dynamic range. However, the exact physiological nature of age differences in SDBOLD remains understudied. In a sample of 29 younger and 45 older adults, we examined the contribution of vascular factors to age group differences in fixation-based SDBOLD using (1) a dual-echo BOLD/pseudo-continuous arterial spin labeling (pCASL) sequence, and (2) hypercapnia via a computer-controlled gas delivery system. We tested the hypothesis that, although SDBOLD may relate to individual differences in absolute cerebral blood flow (CBF), BOLD cerebrovascular reactivity (CVR), or maximum BOLD signal change (M), robust age differences in SDBOLD would remain after multiple statistical controls for these vascular factors. As expected, our results demonstrated that brain regions in which younger adults expressed higher SDBOLD persisted after comprehensive control of vascular effects. Our findings thus further establish BOLD signal variability as an important marker of the aging brain.

PMID: 28860455 [PubMed - in process]