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Development of "[11C]kits" for a fast, efficient and reliable production of carbon-11 labeled radiopharmaceuticals for Positron Emission Tomography.

Author(s): Jolly D, Hopewell R, Kovacevic M, Li QY, Soucy JP, Kostikov A

Appl Radiat Isot. 2017 Mar;121:76-81 Authors: Jolly D, Hopewell R, Kovacevic M, Li QY, Soucy JP, Kostikov A

Article GUID: 28038410
Title:Development of "[11C]kits" for a fast, efficient and reliable production of carbon-11 labeled radiopharmaceuticals for Positron Emission Tomography.
Authors:Jolly D,  Hopewell R,  Kovacevic M,  Li QY,  Soucy JP,  Kostikov A
Link:https://www.ncbi.nlm.nih.gov/pubmed/28038410?dopt=Abstract
DOI:10.1016/j.apradiso.2016.11.020
Category:Appl Radiat Isot
PMID:28038410
Dept Affiliation: PERFORM
1 Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4.
2 Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4; Concordia-PERFORM Centre, Concordia University, Montreal, Canada.

Description:

Development of "[11C]kits" for a fast, efficient and reliable production of carbon-11 labeled radiopharmaceuticals for Positron Emission Tomography.

Appl Radiat Isot. 2017 Mar;121:76-81

Authors: Jolly D, Hopewell R, Kovacevic M, Li QY, Soucy JP, Kostikov A

Abstract

Translation of carbon-11 labeled PET tracers to clinical settings is currently impeded by the technical difficulties associated with [11C]CO2 conversion into the highly reactive methylating agents [11C]CH3I and [11C]CH3OTf using automated modules relying on stationary valves. Here we describe development of the first in its kind "[11C]kit" for production of carbon-11 radiotracer using disposable manifolds. This method proved to be very reliable and allows for consecutive production of PET tracers with minimal intervals between the syntheses.

PMID: 28038410 [PubMed - indexed for MEDLINE]