Keyword search (3,448 papers available)


Neural substrates of appetitive and aversive prediction error.

Author(s): Iordanova MD, Yau JO, McDannald MA, Corbit LH

Prediction error, defined by the discrepancy between real and expected outcomes, lies at the core of associative learning. Behavioural investigations have provided evidence that prediction error up- and down-regulates associative relationships, and allocate...

Article GUID: 33453307
Adaptive behaviour under conflict: deconstructing extinction, reversal, and active avoidance learning.

Author(s): Manning EE, Bradfield LA, Iordanova MD

In complex environments, organisms must respond adaptively to situations despite conflicting information. Under natural (i.e. non-laboratory) circumstances, it is rare that cues or responses are consistently paired with a single outcome. Inconsistent pairin...

Article GUID: 33035525
Different methods of fear reduction are supported by distinct cortical substrates.

Author(s): Lay BP, Pitaru AA, Boulianne N, Esber GR, Iordanova MD

Elife. 2020 Jun 26;9: Authors: Lay BP, Pitaru AA, Boulianne N, Esber GR, Iordanova MD

Article GUID: 32589138
A self-initiated cue-reward learning procedure for neural recording in rodents.

Author(s): Reverte I, Volz S, Alhazmi FH, Kang M, Kaufman K, Chan S, Jou C, Iordanova MD, Esber GR

J Neurosci Methods. 2020 Mar 02;:108671 Authors: Reverte I, Volz S, Alhazmi FH, Kang M, Kaufman K, Chan S, Jou C, Iordanova MD, Esber GR

Article GUID: 32135212
Causal evidence supporting the proposal that dopamine transients function as temporal difference prediction errors.

Author(s): Maes EJP, Sharpe MJ, Usypchuk AA, Lozzi M, Chang CY, Gardner MPH, Schoenbaum G, Iordanova MD

Nat Neurosci. 2020 Jan 20;: Authors: Maes EJP, Sharpe MJ, Usypchuk AA, Lozzi M, Chang CY, Gardner MPH, Schoenbaum G, Iordanova MD

Article GUID: 31959935
Neural correlates of two different types of extinction learning in the amygdala central nucleus.

Author(s): Iordanova MD, Deroche ML, Esber GR, Schoenbaum G

Nat Commun. 2016 08 17;7:12330 Authors: Iordanova MD, Deroche ML, Esber GR, Schoenbaum G

Article GUID: 27531638
Dopamine Signaling Is Critical for Supporting Cue-Driven Behavioral Control.

Author(s): Iordanova MD

Neuroscience. 2019 May 17;: Authors: Iordanova MD

Article GUID: 31103706
Thought control with the dopamine transient.

Author(s): Iordanova MD

Learn Behav. 2018 Oct 18;: Authors: Iordanova MD

Article GUID: 30338459
Dissociation of Appetitive Overexpectation and Extinction in the Infralimic Cortex.

Author(s): Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Cereb Cortex. 2018 Oct 29;: Authors: Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Article GUID: 30371757
Corrigendum: Dissociation of Appetitive Overexpectation and Extinction in the Infralimbic Cortex.

Author(s): Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Cereb Cortex. 2019 Apr 01;29(4):1703 Authors: Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD PMID: 30590441 [PubMed - in process]

Article GUID: 30590441
Title:Neural correlates of two different types of extinction learning in the amygdala central nucleus.
Authors:Iordanova MD,  Deroche ML,  Esber GR,  Schoenbaum G
Link:https://www.ncbi.nlm.nih.gov/pubmed/27531638?dopt=Abstract
DOI:10.1038/ncomms12330
Category:Nat Commun
PMID:27531638
Dept Affiliation: CSBN
1 National Institute on Drug Abuse Intramural Research Program, Cellular Neurobiology Research Branch, Behavioral Neurophysiology Research Section, 251 Bayview Boulevard, Baltimore, Maryland 21224, USA.
2 Department of Anatomy and Neurobiology, University of Maryland, School of Medicine, 20 Penn Street, Baltimore, Maryland 21201, USA.
3 Department of Psychology and Centre for Studies in Behavioral Neurobiology, Concordia University, 7141 Sherbrooke West, Montreal, Quebec, Canada H4B 1R6.
4 Center for Research on Brain, Language, and Music, McGill University, 3640 Rue de la Montagne, Montreal, Quebec, Canada H3G 2A8.
5 Solomon H. Snyder Department of Neuroscience, the Johns Hopkins Univeristy, Baltimore, Maryland 21287, USA.

Description:

Neural correlates of two different types of extinction learning in the amygdala central nucleus.

Nat Commun. 2016 08 17;7:12330

Authors: Iordanova MD, Deroche ML, Esber GR, Schoenbaum G

Abstract

Extinction is a fundamental form of memory updating in which one learns to stop expecting an event that no longer occurs. This learning ensues when one experiences a change in environmental contingencies, that is, when an expected outcome fails to occur (simple extinction), or when a novel inflated expectation of a double outcome (overexpectation) is in conflict with the real outcome, and is a process that has been linked to amygdala function. Here, we show that in rats, the same neuronal population in the amygdala central nucleus updates reward expectancies and behaviour in both types of extinction, and neural changes in one paradigm are reflected in the other. This work may have implications for the management of addiction and anxiety disorders that require treatments based on the outcome omission, and disorders such as obesity that could use overexpectation, but not omission strategies.

PMID: 27531638 [PubMed - indexed for MEDLINE]