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Candida albicans targets that potentially synergize with fluconazole.

Author(s): Lu H, Shrivastava M, Whiteway M, Jiang Y

Fluconazole has characteristics that make it widely used in the clinical treatment of C. albicans infections. However, fluconazole has only a fungistatic activity in C. albicans, therefore, in the long-term treatment of C. albicans infection with fluconazol...

Article GUID: 33587857
Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.

Author(s): Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Cell Rep. 2020 Jun 30;31(13):107838 Authors: Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Article GUID: 32610139
Title:Candida albicans targets that potentially synergize with fluconazole.
Authors:Lu H,  Shrivastava M,  Whiteway M,  Jiang Y
Link:https://www.ncbi.nlm.nih.gov/pubmed/33587857
Category:Crit Rev Microbiol
PMID:33587857
Dept Affiliation: BIOLOGY
1 Department of Pharmacology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
2 Department of Biology, Concordia University, Montreal, QC, Canada.

Description:

Candida albicans targets that potentially synergize with fluconazole.

Crit Rev Microbiol. 2021 Feb 15; :1-15

Authors: Lu H, Shrivastava M, Whiteway M, Jiang Y

Abstract

Fluconazole has characteristics that make it widely used in the clinical treatment of C. albicans infections. However, fluconazole has only a fungistatic activity in C. albicans, therefore, in the long-term treatment of C. albicans infection with fluconazole, C. albicans has the potential to acquire fluconazole resistance. A promising approach to increase fluconazole's efficacy is identifying potential targets of drugs that can enhance the antifungal effect of fluconazole, or even make the drug fungicidal. In this review, we systematically provide a global overview of potential targets of drugs synergistic with fluconazole in C. albicans, identify new avenues for research on fluconazole potentiation, and highlight the promise of combinatorial strategies with fluconazole in combatting C. albicans infections.

PMID: 33587857 [PubMed - as supplied by publisher]