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Sex differences in regional adipose tissue depots pose different threats for the development of Type 2 diabetes in males and females

Author(s): Kerri Z Delaney

Type 2 diabetes mellitus (T2DM) affects males and females disproportionately. In midlife, more males have T2DM than females. The sex difference in T2DM prevalence is, in part, explained by differences in regional adipose tissue characteristics. With obesity...

Article GUID: 34985183
Title:Sex differences in regional adipose tissue depots pose different threats for the development of Type 2 diabetes in males and females
Authors:Kerri Z Delaney
Link:https://pubmed.ncbi.nlm.nih.gov/34985183/
DOI:10.1111/obr.13393
Category:
PMID:34985183
Dept Affiliation: PERFORM
1 Department of Health, Kinesiology and Applied Physiology, Concordia University, Montréal, Québec, Canada.
2 Metabolism, Obesity and Nutrition Lab, PERFORM Centre, Concordia University, Montréal, Québec, Canada.
3 Centre de recherche - Axe maladies chroniques, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada.

Description:

Type 2 diabetes mellitus (T2DM) affects males and females disproportionately. In midlife, more males have T2DM than females. The sex difference in T2DM prevalence is, in part, explained by differences in regional adipose tissue characteristics. With obesity, changes to regional adipokine and cytokine release increases the risk of T2DM in both males and females with males having greater levels of TNFa and females having greater levels of leptin, CRP, and adiponectin. Regional immune cell...