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Early Life History of Coreoperca herzi in Han River, Korea.

Author(s): Park JM, Jeon HB, Suk HY, Cho SJ, Han KH

Dev Reprod. 2020 Mar;24(1):63-70 Authors: Park JM, Jeon HB, Suk HY, Cho SJ, Han KH

Article GUID: 32411919
Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease.

Author(s): Hadoux X, Hui F, Lim JKH, Masters CL, Pébay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Les...

Nat Commun. 2019 Sep 17;10(1):4227 Authors: Hadoux X, Hui F, Lim JKH, Masters CL, Pébay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Lesage F, ...

Article GUID: 31530809
Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space.

Author(s): Veri AO, Miao Z, Shapiro RS, Tebbji F, O'Meara TR, Kim SH, Colazo J, Tan K, Vyas VK, Whiteway M, Robbins N, Wong KH, Cowen LE

PLoS Genet. 2018 03;14(3):e1007270 Authors: Veri AO, Miao Z, Shapiro RS, Tebbji F, O'Meara TR, Kim SH, Colazo J, Tan K, Vyas VK, Whiteway M, Robbins N, Wong KH, Cowen LE

Article GUID: 29590106
Inhibition of β-site amyloid precursor protein cleaving enzyme 1 and cholinesterases by pterosins via a specific structure-activity relationship with a strong BBB permeability.

Author(s): Jannat S, Balupuri A, Ali MY, Hong SS, Choi CW, Choi YH, Ku JM, Kim WJ, Leem JY, Kim JE, Shrestha AC, Ham HN, Lee KH, Kim DM, Kang NS, Park GH

Exp Mol Med. 2019 02 12;51(2):12 Authors: Jannat S, Balupuri A, Ali MY, Hong SS, Choi CW, Choi YH, Ku JM, Kim WJ, Leem JY, Kim JE, Shrestha AC, Ham HN, Lee KH, Kim DM, Kang NS, Park GH

Article GUID: 30755593
Title:Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space.
Authors:Veri AO,  Miao Z,  Shapiro RS,  Tebbji F,  O'Meara TR,  Kim SH,  Colazo J,  Tan K,  Vyas VK,  Whiteway M,  Robbins N,  Wong KH,  Cowen LE
Link:https://www.ncbi.nlm.nih.gov/pubmed/29590106?dopt=Abstract
DOI:10.1371/journal.pgen.1007270
Category:PLoS Genet
PMID:29590106
Dept Affiliation: BIOLOGY
1 Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
2 Faculty of Health Sciences, University of Macau, Macau SAR, China.
3 Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
4 Infectious Disease Research Centre, Université Laval, Quebec City, Quebec, Canada.
5 Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
6 Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America.
7 Department of Biology, Concordia University, Montréal, Quebec, Canada.

Description:

Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space.

PLoS Genet. 2018 03;14(3):e1007270

Authors: Veri AO, Miao Z, Shapiro RS, Tebbji F, O'Meara TR, Kim SH, Colazo J, Tan K, Vyas VK, Whiteway M, Robbins N, Wong KH, Cowen LE

Abstract

The capacity to respond to temperature fluctuations is critical for microorganisms to survive within mammalian hosts, and temperature modulates virulence traits of diverse pathogens. One key temperature-dependent virulence trait of the fungal pathogen Candida albicans is its ability to transition from yeast to filamentous growth, which is induced by environmental cues at host physiological temperature. A key regulator of temperature-dependent morphogenesis is the molecular chaperone Hsp90, which has complex functional relationships with the transcription factor Hsf1. Although Hsf1 controls global transcriptional remodeling in response to heat shock, its impact on morphogenesis remains unknown. Here, we establish an intriguing paradigm whereby overexpression or depletion of C. albicans HSF1 induces morphogenesis in the absence of external cues. HSF1 depletion compromises Hsp90 function, thereby driving filamentation. HSF1 overexpression does not impact Hsp90 function, but rather induces a dose-dependent expansion of Hsf1 direct targets that drives overexpression of positive regulators of filamentation, including Brg1 and Ume6, thereby bypassing the requirement for elevated temperature during morphogenesis. This work provides new insight into Hsf1-mediated environmentally contingent transcriptional control, implicates Hsf1 in regulation of a key virulence trait, and highlights fascinating biology whereby either overexpression or depletion of a single cellular regulator induces a profound developmental transition.

PMID: 29590106 [PubMed - indexed for MEDLINE]