Keyword search (3,619 papers available)


Development of "[11C]kits" for a fast, efficient and reliable production of carbon-11 labeled radiopharmaceuticals for Positron Emission Tomography.

Author(s): Jolly D, Hopewell R, Kovacevic M, Li QY, Soucy JP, Kostikov A

Appl Radiat Isot. 2017 Mar;121:76-81 Authors: Jolly D, Hopewell R, Kovacevic M, Li QY, Soucy JP, Kostikov A

Article GUID: 28038410
Effect of (Z)-isomer content on [11C]ABP688 binding potential in humans.

Author(s): Smart K, Cox SML, Kostikov A, Shalai A, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M

Eur J Nucl Med Mol Imaging. 2019 May;46(5):1175-1178 Authors: Smart K, Cox SML, Kostikov A, Shalai A, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M

Article GUID: 30607444
Quantification of brain cholinergic denervation in Alzheimer's disease using PET imaging with [18F]-FEOBV.

Author(s): Aghourian M, Legault-Denis C, Soucy JP, Rosa-Neto P, Gauthier S, Kostikov A, Gravel P, Bédard MA

Mol Psychiatry. 2017 11;22(11):1531-1538 Authors: Aghourian M, Legault-Denis C, Soucy JP, Rosa-Neto P, Gauthier S, Kostikov A, Gravel P, Bédard MA

Article GUID: 28894304
Title:Development of "[11C]kits" for a fast, efficient and reliable production of carbon-11 labeled radiopharmaceuticals for Positron Emission Tomography.
Authors:Jolly D,  Hopewell R,  Kovacevic M,  Li QY,  Soucy JP,  Kostikov A
Link:https://www.ncbi.nlm.nih.gov/pubmed/28038410?dopt=Abstract
DOI:10.1016/j.apradiso.2016.11.020
Category:Appl Radiat Isot
PMID:28038410
Dept Affiliation: PERFORM
1 Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4.
2 Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4; Concordia-PERFORM Centre, Concordia University, Montreal, Canada.

Description:

Development of "[11C]kits" for a fast, efficient and reliable production of carbon-11 labeled radiopharmaceuticals for Positron Emission Tomography.

Appl Radiat Isot. 2017 Mar;121:76-81

Authors: Jolly D, Hopewell R, Kovacevic M, Li QY, Soucy JP, Kostikov A

Abstract

Translation of carbon-11 labeled PET tracers to clinical settings is currently impeded by the technical difficulties associated with [11C]CO2 conversion into the highly reactive methylating agents [11C]CH3I and [11C]CH3OTf using automated modules relying on stationary valves. Here we describe development of the first in its kind "[11C]kit" for production of carbon-11 radiotracer using disposable manifolds. This method proved to be very reliable and allows for consecutive production of PET tracers with minimal intervals between the syntheses.

PMID: 28038410 [PubMed - indexed for MEDLINE]