Keyword search (3,448 papers available)


Cue-alcohol associative learning in female rats.

Author(s): Cofresí RU, Monfils MH, Chaudhri N, Gonzales RA, Lee HJ

The ability of environmental cues to trigger alcohol-seeking behaviors is believed to facilitate problematic alcohol use. We previously showed that the development of this cue-evoked alcohol approach reflects cue-alcohol learning and memory in the adult mal...

Article GUID: 31002878
Alcohol-associated antecedent stimuli elicit alcohol seeking in non-dependent rats and may activate the insula.

Author(s): Cofresí RU, Grote DJ, Le EVT, Monfils MH, Chaudhri N, Gonzales RA, Lee HJ

Alcohol. 2019 May;76:91-102 Authors: Cofresí RU, Grote DJ, Le EVT, Monfils MH, Chaudhri N, Gonzales RA, Lee HJ

Article GUID: 30612041
Postretrieval Extinction Attenuates Alcohol Cue Reactivity in Rats.

Author(s): Cofresí RU, Lewis SM, Chaudhri N, Lee HJ, Monfils MH, Gonzales RA

Alcohol Clin Exp Res. 2017 03;41(3):608-617 Authors: Cofresí RU, Lewis SM, Chaudhri N, Lee HJ, Monfils MH, Gonzales RA

Article GUID: 28169439
Characterizing conditioned reactivity to sequential alcohol-predictive cues in well-trained rats.

Author(s): Cofresí RU, Lee HJ, Monfils MH, Chaudhri N, Gonzales RA

Alcohol. 2018 Jun;69:41-49 Authors: Cofresí RU, Lee HJ, Monfils MH, Chaudhri N, Gonzales RA

Article GUID: 29635111
Title:Postretrieval Extinction Attenuates Alcohol Cue Reactivity in Rats.
Authors:Cofresí RU,  Lewis SM,  Chaudhri N,  Lee HJ,  Monfils MH,  Gonzales RA
Link:https://www.ncbi.nlm.nih.gov/pubmed/28169439?dopt=Abstract
Category:Alcohol Clin Exp Res
PMID:28169439
Dept Affiliation: CSBN
1 Institute for Neuroscience, The University of Texas at Austin, Austin, Texas.
2 Department of Psychology, The University of Washington, Seattle, Washington.
3 Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
4 Department of Psychology, Institute for Neuroscience, The University of Texas at Austin, Austin, Texas.
5 Division of Pharmacology & Toxicology, Institute for Neuroscience, The University of Texas at Austin, Austin, Texas.

Description:

Postretrieval Extinction Attenuates Alcohol Cue Reactivity in Rats.

Alcohol Clin Exp Res. 2017 03;41(3):608-617

Authors: Cofresí RU, Lewis SM, Chaudhri N, Lee HJ, Monfils MH, Gonzales RA

Abstract

BACKGROUND: Conditioned responses to alcohol-associated cues can hinder recovery from alcohol use disorder (AUD). Cue exposure (extinction) therapy (CET) can reduce reactivity to alcohol cues, but its efficacy is limited by phenomena such as spontaneous recovery and reinstatement that can cause a return of conditioned responding after extinction. Using a preclinical model of alcohol cue reactivity in rats, we evaluated whether the efficacy of alcohol CET could be improved by conducting CET during the memory reconsolidation window after retrieval of cue-alcohol associations.

METHODS: Rats were provided with intermittent access to unsweetened alcohol. Rats were then trained to predict alcohol access based on a visual cue. Next, rats were treated with either standard extinction (n = 14) or postretrieval extinction (n = 13). Rats were then tested for long-term memory of extinction and susceptibility to spontaneous recovery and reinstatement.

RESULTS: Despite equivalent extinction, rats treated with postretrieval extinction exhibited reduced spontaneous recovery and reinstatement relative to rats treated with standard extinction.

CONCLUSIONS: Postretrieval CET shows promise for persistently attenuating the risk to relapse posed by alcohol cues in individuals with AUD.

PMID: 28169439 [PubMed - indexed for MEDLINE]