Keyword search (3,448 papers available)


Simulation and computer modeling of asphaltene in different solvents on oil-water interfaces using a molecular dynamic methodology.

Author(s): Yuan J, Elektorowicz M, Chen Z, Segun GA, Vakili M, Zhong L, Wang B, Zhu J, Wu Y

J Mol Graph Model. 2019 Sep 13;93:107450 Authors: Yuan J, Elektorowicz M, Chen Z, Segun GA, Vakili M, Zhong L, Wang B, Zhu J, Wu Y

Article GUID: 31542686
Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η opposite Intrastrand Cross-Linked DNA.

Author(s): O'Flaherty DK, Guengerich FP, Egli M, Wilds CJ

Biochemistry. 2015 Dec 29;54(51):7449-56 Authors: O'Flaherty DK, Guengerich FP, Egli M, Wilds CJ

Article GUID: 26624500
Diagnostic accuracy of the Depression subscale of the Hospital Anxiety and Depression Scale (HADS-D) for detecting major depression: protocol for a systematic review and individual patient data meta-analyses.

Author(s): Thombs BD, Benedetti A, Kloda LA, Levis B, Azar M, Riehm KE, Saadat N, Cuijpers P, Gilbody S, Ioannidis JP, McMillan D, Patten SB, Shrier I,...

BMJ Open. 2016 Apr 13;6(4):e011913 Authors: Thombs BD, Benedetti A, Kloda LA, Levis B, Azar M, Riehm KE, Saadat N, Cuijpers P, Gilbody S, Ioannidis JP, McMillan D, Patten SB, Shrier I, Steele RJ, ...

Article GUID: 27075844
SnowyOwl: accurate prediction of fungal genes by using RNA-Seq and homology information to select among ab initio models.

Author(s): Reid I, O'Toole N, Zabaneh O, Nourzadeh R, Dahdouli M, Abdellateef M, Gordon PM, Soh J, Butler G, Sensen CW, Tsang A

BMC Bioinformatics. 2014 Jul 01;15:229 Authors: Reid I, O'Toole N, Zabaneh O, Nourzadeh R, Dahdouli M, Abdellateef M, Gordon PM, Soh J, Butler G, Sensen CW, Tsang A

Article GUID: 24980894
A Lithium-Sulfur Battery using a 2D Current Collector Architecture with a Large-Sized Sulfur Host Operated under High Areal Loading and Low E/S Ratio.

Author(s): Li M, Zhang Y, Bai Z, Liu WW, Liu T, Gim J, Jiang G, Yuan Y, Luo D, Feng K, Yassar RS, Wang X, Chen Z, Lu J

Adv Mater. 2018 Nov;30(46):e1804271 Authors: Li M, Zhang Y, Bai Z, Liu WW, Liu T, Gim J, Jiang G, Yuan Y, Luo D, Feng K, Yassar RS, Wang X, Chen Z, Lu J

Article GUID: 30368935
Lesion Orientation of O4-Alkylthymidine Influences Replication by Human DNA Polymerase η.

Author(s): O'Flaherty DK, Patra A, Su Y, Guengerich FP, Egli M, Wilds CJ

Chem Sci. 2016 Aug 01;7(8):4896-4904 Authors: O'Flaherty DK, Patra A, Su Y, Guengerich FP, Egli M, Wilds CJ

Article GUID: 27574558
O6-2'-Deoxyguanosine-butylene-O6-2'-deoxyguanosine DNA Interstrand Cross-Links Are Replication-Blocking and Mutagenic DNA Lesions.

Author(s): Xu W, Kool D, O'Flaherty DK, Keating AM, Sacre L, Egli M, Noronha A, Wilds CJ, Zhao L

Chem Res Toxicol. 2016 11 21;29(11):1872-1882 Authors: Xu W, Kool D, O'Flaherty DK, Keating AM, Sacre L, Egli M, Noronha A, Wilds CJ, Zhao L

Article GUID: 27768841
The Effect of Synbiotic Supplementation on Growth Parameters in Mild to Moderate FTT Children Aged 2-5 Years.

Author(s): Aflatoonian M, Taghavi Ardakani A, Modarresi SZ, Modaresi V, Karimi M, Ordooei M, Vakili M, Pakseresht B

Probiotics Antimicrob Proteins. 2019 Jan 09;: Authors: Aflatoonian M, Taghavi Ardakani A, Modarresi SZ, Modaresi V, Karimi M, Ordooei M, Vakili M, Pakseresht B

Article GUID: 30627885
Multimodal 18F-Fluciclovine PET/MRI and Ultrasound-Guided Neurosurgery of an Anaplastic Oligodendroglioma.

Author(s): Karlberg A, Berntsen EM, Johansen H, Myrthue M, Skjulsvik AJ, Reinertsen I, Esmaeili M, Dai HY, Xiao Y, Rivaz H, Borghammer P, Solheim O, Eikenes L

World Neurosurg. 2017 Dec;108:989.e1-989.e8 Authors: Karlberg A, Berntsen EM, Johansen H, Myrthue M, Skjulsvik AJ, Reinertsen I, Esmaeili M, Dai HY, Xiao Y, Rivaz H, Borghammer P, Solheim O, Eikenes L

Article GUID: 28844925
A comparison of muscle activation and knee mechanics during gait between patients with non-traumatic and post-traumatic knee osteoarthritis.

Author(s): Robbins SM, Morelli M, Martineau PA, St-Onge N, Boily M, Dimentberg R, Antoniou J

A comparison of muscle activation and knee mechanics during gait between patients with non-traumatic and post-traumatic knee osteoarthritis.
Osteoarthritis Cartilage. 2019 Mar 18;:
Authors: Robbins SM, Morelli M, Martineau PA, St-Onge N, Boily M, Di...

Article GUID: 30898621
Title:Lesion Orientation of O4-Alkylthymidine Influences Replication by Human DNA Polymerase η.
Authors:O'Flaherty DK,  Patra A,  Su Y,  Guengerich FP,  Egli M,  Wilds CJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/27574558?dopt=Abstract
Category:Chem Sci
PMID:27574558
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University, Montréal, Québec H4B1R6, Canada.
2 Department of Biochemistry, Vanderbilt Institute of Chemical Biology, and Center for Structural Biology, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, United States.

Description:

Lesion Orientation of O4-Alkylthymidine Influences Replication by Human DNA Polymerase ?.

Chem Sci. 2016 Aug 01;7(8):4896-4904

Authors: O'Flaherty DK, Patra A, Su Y, Guengerich FP, Egli M, Wilds CJ

Abstract

DNA lesions that elude repair may undergo translesion synthesis catalyzed by Y-family DNA polymerases. O4-Alkylthymidines, persistent adducts that can result from carcinogenic agents, may be encountered by DNA polymerases. The influence of lesion orientation around the C4-O4 bond on processing by human DNA polymerase ? (hPol ?) was studied for oligonucleotides containing O4-methylthymidine, O4-ethylthymidine, and analogs restricting the O4-methylene group in an anti-orientation. Primer extension assays revealed that the O4-alkyl orientation influences hPol ? bypass. Crystal structures of hPol ?•DNA•dNTP ternary complexes with O4-methyl- or O4-ethylthymidine in the template strand showed the nucleobase of the former lodged near the ceiling of the active site, with the syn-O4-methyl group engaged in extensive hydrophobic interactions. This unique arrangement for O4-methylthymidine with hPol ?, inaccessible for the other analogs due to steric/conformational restriction, is consistent with differences observed for nucleotide incorporation and supports the concept that lesion conformation influences extension across DNA damage. Together, these results provide mechanistic insights on the mutagenicity of O4MedT and O4EtdT when acted upon by hPol ?.

PMID: 27574558 [PubMed - as supplied by publisher]