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Long-term effects of PM2·5 on neurological disorders in the American Medicare population: a longitudinal cohort study.

Author(s): Shi L, Wu X, Danesh Yazdi M, Braun D, Abu Awad Y, Wei Y, Liu P, Di Q, Wang Y, Schwartz J, Dominici F, Kioumourtzoglou MA, Zanobetti A...

BACKGROUND: Accumulating evidence links fine particulate matter (PM2·5) to premature mortality, cardiovascular disease, and respiratory disease. However, less is known about the influence of PM2·5 ...

Article GUID: 33091388
Deficiencies in vesicular transport mediated by TRAPPC4 are associated with severe syndromic intellectual disability.

Author(s): Van Bergen NJ, Guo Y, Al-Deri N, Lipatova Z, Stanga D, Zhao S, Murtazina R, Gyurkovska V, Pehlivan D, Mitani T, Gezdirici A, Antony J, Colli...

The conserved transport protein particle (TRAPP) complexes regulate key trafficking events and are required for autophagy. TRAPPC4, like its yeast Trs23 orthologue, is a core component of the TRAPP...

Article GUID: 31794024
Title:Long-term effects of PM2·5 on neurological disorders in the American Medicare population: a longitudinal cohort study.
Authors:Shi L,  Wu X,  Danesh Yazdi M,  Braun D,  Abu Awad Y,  Wei Y,  Liu P,  Di Q,  Wang Y,  Schwartz J,  Dominici F,  Kioumourtzoglou MA,  Zanobetti A
Link:https://www.ncbi.nlm.nih.gov/pubmed/33091388
DOI:10.1016/S2542-5196(20)30227-8
Category:Lancet Planet Health
PMID:33091388
Dept Affiliation: PSYCHOLOGY
1 Department of Environmental Health, Harvard T H Chan School of Public Health, Boston, MA, USA; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
2 Department of Biostatistics, Harvard T H Chan School of Public Health, Boston, MA, USA.
3 Department of Environmental Health, Harvard T H Chan School of Public Health, Boston, MA, USA.
4 Department of Biostatistics, Harvard T H Chan School of Public Health, Boston, MA, USA; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.
5 Department of Psychology, Concordia University, Montreal, QC, Canada.
6 School of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
7 Vanke School of Public Health, Tsinghua University, Beijing, China.
8 Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
9 Department of Environmental Health, Harvard T H Chan School of Public Health, Boston, MA, USA. Electronic address: azanobet@hsph.harvard.edu.

Description:

Long-term effects of PM2·5 on neurological disorders in the American Medicare population: a longitudinal cohort study.

Lancet Planet Health. 2020 Oct 19; :

Authors: Shi L, Wu X, Danesh Yazdi M, Braun D, Abu Awad Y, Wei Y, Liu P, Di Q, Wang Y, Schwartz J, Dominici F, Kioumourtzoglou MA, Zanobetti A

Abstract

BACKGROUND: Accumulating evidence links fine particulate matter (PM2·5) to premature mortality, cardiovascular disease, and respiratory disease. However, less is known about the influence of PM2·5 on neurological disorders. We aimed to investigate the effect of long-term PM2·5 exposure on development of Parkinson's disease or Alzheimer's disease and related dementias.

METHODS: We did a longitudinal cohort study in which we constructed a population-based nationwide open cohort including all fee-for-service Medicare beneficiaries (aged =65 years) in the contiguous United States (2000-16) with no exclusions. We assigned PM2·5 postal code (ie, ZIP code) concentrations based on mean annual predictions from a high-resolution model. To accommodate our very large dataset, we applied Cox-equivalent Poisson models with parallel computing to estimate hazard ratios (HRs) for first hospital admission for Parkinson's disease or Alzheimer's disease and related dementias, adjusting for potential confounders in the health models.

FINDINGS: Between Jan 1, 2000, and Dec 31, 2016, of 63?038?019 individuals who were aged 65 years or older during the study period, we identified 1·0 million cases of Parkinson's disease and 3·4 million cases of Alzheimer's disease and related dementias based on primary and secondary diagnosis billing codes. For each 5 µg/m3 increase in annual PM2·5 concentrations, the HR was 1·13 (95% CI 1·12-1·14) for first hospital admission for Parkinson's disease and 1·13 (1·12-1·14) for first hospital admission for Alzheimer's disease and related dementias. For both outcomes, there was strong evidence of linearity at PM2·5 concentrations less than 16 µg/m3 (95th percentile of the PM2·5 distribution), followed by a plateaued association with increasingly larger confidence bands.

INTERPRETATION: We provide evidence that exposure to annual mean PM2·5 in the USA is significantly associated with an increased hazard of first hospital admission with Parkinson's disease and Alzheimer's disease and related dementias. For the ageing American population, improving air quality to reduce PM2·5 concentrations to less than current national standards could yield substantial health benefits by reducing the burden of neurological disorders.

FUNDING: The Health Effects Institute, The National Institute of Environmental Health Sciences, The National Institute on Aging, and the HERCULES Center.

PMID: 33091388 [PubMed - as supplied by publisher]