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Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking.

Author(s): Lafferty CK, Yang AK, Mendoza JA, Britt JP

Cell Rep. 2020 Mar 17;30(11):3729-3742.e3 Authors: Lafferty CK, Yang AK, Mendoza JA, Britt JP

Article GUID: 32187545
Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability.

Author(s): Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP

Biol Psychiatry. 2019 Sep 19;: Authors: Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP

Article GUID: 31699294
Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value.

Author(s): Mendoza JA, Lafferty CK, Yang AK, Britt JP

Cell Rep. 2019 Nov 05;29(6):1429-1437.e3 Authors: Mendoza JA, Lafferty CK, Yang AK, Britt JP

Article GUID: 31693885
Coordinated Reductions in Excitatory Input to the Nucleus Accumbens Underlie Food Consumption.

Author(s): Reed SJ, Lafferty CK, Mendoza JA, Yang AK, Davidson TJ, Grosenick L, Deisseroth K, Britt JP

Neuron. 2018 Sep 19;99(6):1260-1273.e4 Authors: Reed SJ, Lafferty CK, Mendoza JA, Yang AK, Davidson TJ, Grosenick L, Deisseroth K, Britt JP

Article GUID: 30146308
Title:Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability.
Authors:Yang AK,  Mendoza JA,  Lafferty CK,  Lacroix F,  Britt JP
Link:https://www.ncbi.nlm.nih.gov/pubmed/31699294?dopt=Abstract
DOI:10.1016/j.biopsych.2019.09.007
Category:Biol Psychiatry
PMID:31699294
Dept Affiliation: CSBN
1 Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
2 Department of Psychology, McGill University, Montreal, Quebec, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
3 Department of Psychology, McGill University, Montreal, Quebec, Canada.
4 Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada; Department of Psychology, McGill University, Montreal, Quebec, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada. Electronic address: jonathan.britt@mcgill.ca.

Description:

Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability.

Biol Psychiatry. 2019 Sep 19;:

Authors: Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP

Abstract

BACKGROUND: Insight into the neural basis of hedonic processing has come from studies of food palatability in rodents. Pharmacological manipulations of the nucleus accumbens shell (NAcSh) have repeatedly been demonstrated to increase hedonic taste reactivity, yet the contribution of specific NAcSh circuit components is unknown.

METHODS: Bidirectional optogenetic manipulations were targeted to the principal NAcSh projection neurons and afferent pathways in mice during free feeding assays. Number of licks per bout of consumption was used as a measure of food palatability as it was confirmed to track sucrose concentration and subjective flavor preferences.

RESULTS: Photoinhibition of NAcSh neurons, whether general or cell-type specific, was found to alter consumption without affecting its hedonic impact. Among the principal excitatory afferent pathways, we showed that ventral hippocampal (vHipp) input alone enhances palatability upon low-frequency photostimulation time-locked to consumption. This enhancement in palatability was independent of opioid signaling and not recapitulated by NAcSh or dopamine neuron photostimulation. We further demonstrated that vHipp input photostimulation is sufficient to condition a flavor preference, while its inhibition impedes sucrose-driven flavor preference conditioning.

CONCLUSIONS: These results demonstrate a novel contribution of vHipp-NAcSh pathway activity to palatability that may relate to its innervation of a particular region or neuronal ensemble in the NAcSh. These findings are consistent with the evidence that vHipp-NAcSh activity is relevant to the pathophysiology of anhedonia and depression as well as the increasing appreciation of hippocampal involvement in people's food pleasantness ratings, hunger, and weight.

PMID: 31699294 [PubMed - as supplied by publisher]