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Photocatalytic degradation of sulfamethoxazole by hierarchical magnetic ZnO@g-C3N4: RSM optimization, kinetic study, reaction pathway and toxicity evaluation.

Author(s): Mirzaei A, Yerushalmi L, Chen Z, Haghighat F

J Hazard Mater. 2018 Oct 05;359:516-526 Authors: Mirzaei A, Yerushalmi L, Chen Z, Haghighat F

Article GUID: 30086522
Effects of ZnO nanoparticles on intestinal function and structure in normal/high fat diet-fed rats and Caco-2 cells.

Author(s): Abbasi-Oshaghi E, Mirzaei F, Mirzaei A

Nanomedicine (Lond). 2018 11;13(21):2791-2816 Authors: Abbasi-Oshaghi E, Mirzaei F, Mirzaei A

Article GUID: 30394178
Sonocatalytic removal of ampicillin by Zn(OH)F: Effect of operating parameters, toxicological evaluation and by-products identification.

Author(s): Mirzaei A, Haghighat F, Chen Z, Yerushalmi L

J Hazard Mater. 2019 Apr 22;375:86-95 Authors: Mirzaei A, Haghighat F, Chen Z, Yerushalmi L

Article GUID: 31054533
Title:Effects of ZnO nanoparticles on intestinal function and structure in normal/high fat diet-fed rats and Caco-2 cells.
Authors:Abbasi-Oshaghi E,  Mirzaei F,  Mirzaei A
Link:https://www.ncbi.nlm.nih.gov/pubmed/30394178?dopt=Abstract
Category:Nanomedicine (Lond)
PMID:30394178
Dept Affiliation: ENCS
1 Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
2 Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
3 Department of Anatomy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
4 Department of Building, Civil & Environmental Engineering (BCEE), Faculty of Engineering & Computer Sciences, Concordia University, Montreal, Quebec, Canada.

Description:

Effects of ZnO nanoparticles on intestinal function and structure in normal/high fat diet-fed rats and Caco-2 cells.

Nanomedicine (Lond). 2018 11;13(21):2791-2816

Authors: Abbasi-Oshaghi E, Mirzaei F, Mirzaei A

Abstract

AIM: The present study was carried out to determine the effects of ZnO nanoparticles (ZnO-NPs) on intestinal function and pathophysiological alteration.

MATERIALS & METHODS: ZnO-NPs were synthesized and their characterizations were performed using various techniques. The Wistar male rats fed with normal diet and/or high fat diet (HFD) for 8 weeks and then orally received ZnO-NPs (5, 50 and 100 mg/kg bodyweight) for 28 days. The oxidative stress (SOD, CAT, GPx), inflammatory (TNF-a, iNOS) and apoptosis pathways (Bcl2, Bax and p53) genes expression and protein levels were measured by real-time polymerase chain reaction and available kit, respectively. The activity of Caspase-3, antioxidant capacity, as well as inflammatory markers were determined. The histological alterations of the large and small intestine were also evaluated with haematoxylin and eosin (H&E) as well as TdT dUTP nick end labeling (TUNEL) assay. The biochemical factors, viability and antioxidant activity were also determined in Caco-2 cells.

RESULTS: It was found that the antioxidant enzymes activity and genes expression markedly increased, while inflammatory and apoptosis pathways and TNF-a levels significantly decreased in the intestine of HFD-fed rats treated with 5 mg/kg ZnO-NPs. Intestinal morphological changes were also restored by 5 mg/kg ZnO-NPs in HFD group.

CONCLUSION: Treatment of rats with 50 and 100 mg/kg ZnO-NPs significantly induced intestinal injury, while treatment with 5 mg/kg ZnO nanoparticle normalized intestinal functions and structure. This study showed the synergistic effects of ZnO-NPs and HFD administration on liver enzyme, oxidative stress, apoptosis, inflammation, morphological changes and cell toxicity.

PMID: 30394178 [PubMed - indexed for MEDLINE]