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Feasibility and preliminary efficacy of the LEAD trial: a cluster randomized controlled lifestyle intervention to improve hippocampal volume in older adults at-risk for dementia

Author(s): N D Koblinsky

CONCLUSIONS: High adherence and retention rates were observed among participants and preliminary findings illustrate improvements in diet quality and HbA1c. These results indicate that a larger trial is feasible if difficulties surrounding recruitment can b...

Article GUID: 35139918
Title:Feasibility and preliminary efficacy of the LEAD trial: a cluster randomized controlled lifestyle intervention to improve hippocampal volume in older adults at-risk for dementia
Authors:N D Koblinsky
Link:https://pubmed.ncbi.nlm.nih.gov/35139918/
DOI:10.1186/s40814-022-00977-6
Category:
PMID:35139918
Dept Affiliation: PERFORM
1 Rotman Research Institute, Baycrest Health Sciences, Toronto, Canada.
2 Rotman Research Institute, Baycrest Health Sciences, Toronto, Canada. nanderson@research.baycrest.org.
3 Departments of Psychology and Psychiatry, University of Toronto, Toronto, Canada. nanderson@research.baycrest.org.
4 KITE, Toronto Rehabilitation Institute - the University Health Network, Toronto, Canada.
5 PERFORM Centre, Concordia University, Montreal, Canada.
6 Department of Occupational Sciences and Occupational Therapy and Rehabilitation Sciences Institute, University of Toronto, Toronto, Canada.
7 Hurvitz Brain Sciences, Sunnybrook Research Institute, University of Toronto, Toronto, Canada.
8 University of Waterloo, Waterloo, Canada.
9 Montreal Heart Institute Research Centre, Montreal, Canada.
10 Department of Nutrition, Université de Montréal, Montreal, Canada.
11 Department of Nutritional Sciences, University of Toronto, Toronto, Canada.

Description:

CONCLUSIONS: High adherence and retention rates were observed among participants and preliminary findings illustrate improvements in diet quality and HbA1c. These results indicate that a larger trial is feasible if difficulties surrounding recruitment can be mitigated.