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Prospective Impact of Psychiatric Disorders on Employment Status and Health Care Use in Patients Investigated for Occupational Asthma.

Author(s): Lavoie KL, Favreau H, Paine NJ, Lemière C, Joseph M, Gagnon-Chauvin A, Cartier A, Bacon SL

J Occup Environ Med. 2016 12;58(12):1196-1201 Authors: Lavoie KL, Favreau H, Paine NJ, Lemière C, Joseph M, Gagnon-Chauvin A, Cartier A, Bacon SL

Article GUID: 27930478
Positive and Negative Affect Is Related to Experiencing Chest Pain During Exercise-Induced Myocardial Ischemia.

Author(s): Stébenne P, Bacon SL, Austin A, Paine NJ, Arsenault A, Laurin C, Meloche B, Gordon J, Dupuis J, Lavoie KL

Psychosom Med. 2017 May;79(4):395-403 Authors: Stébenne P, Bacon SL, Austin A, Paine NJ, Arsenault A, Laurin C, Meloche B, Gordon J, Dupuis J, Lavoie KL

Article GUID: 28009652
Impact of Panic Attacks on Bronchoconstriction and Subjective Distress in Asthma Patients With and Without Panic Disorder.

Author(s): Boudreau M, Bacon SL, Paine NJ, Cartier A, Trutschnigg B, Morizio A, Lavoie KL

Psychosom Med. 2017 Jun;79(5):576-584 Authors: Boudreau M, Bacon SL, Paine NJ, Cartier A, Trutschnigg B, Morizio A, Lavoie KL

Article GUID: 28033197
Relationship between antidepressant therapy and risk for cardiovascular events in patients with and without cardiovascular disease.

Author(s): Lavoie KL, Paine NJ, Pelletier R, Arsenault A, Diodati JG, Campbell TS, Pilote L, Bacon SL

Health Psychol. 2018 Nov;37(11):989-999 Authors: Lavoie KL, Paine NJ, Pelletier R, Arsenault A, Diodati JG, Campbell TS, Pilote L, Bacon SL

Article GUID: 30247064
Psychological distress is related to poor health behaviours in COPD and non-COPD patients: Evidence from the CanCOLD study.

Author(s): Paine NJ, Bacon SL, Bourbeau J, Tan WC, Lavoie KL, CanCOLD Study Investigators, Aaron SD, Chapman KR, FitzGerald JM, Hernandez P, Marciniuk ...

Respir Med. 2019 Jan;146:1-9 Authors: Paine NJ, Bacon SL, Bourbeau J, Tan WC, Lavoie KL, CanCOLD Study Investigators, Aaron SD, Chapman KR, FitzGerald JM, Hernandez P, Marciniuk DD, Maltais F, O&#...

Article GUID: 30665505
Association Between Depression, Lung Function and Inflammatory Markers in Patients with Asthma and Occupational Asthma.

Author(s): Paine NJ, Joseph MF, Bacon SL, Julien CA, Cartier A, Ditto B, Favreau H, Lavoie KL

J Occup Environ Med. 2019 Mar 01;: Authors: Paine NJ, Joseph MF, Bacon SL, Julien CA, Cartier A, Ditto B, Favreau H, Lavoie KL

Article GUID: 30855523
Title:Relationship between antidepressant therapy and risk for cardiovascular events in patients with and without cardiovascular disease.
Authors:Lavoie KL,  Paine NJ,  Pelletier R,  Arsenault A,  Diodati JG,  Campbell TS,  Pilote L,  Bacon SL
Link:https://www.ncbi.nlm.nih.gov/pubmed/30247064?dopt=Abstract
Category:Health Psychol
PMID:30247064
Dept Affiliation: HKAP
1 Department of Psychology, University of Québec at Montréal.
2 Montreal Behavioural Medicine Centre, Research Center, CIUSSS-NIM, Hôpital du Sacré-Coeur de Montréal.
3 Department of Psychology, University of Calgary.
4 Division of Clinical Epidemiology, McGill University Health Centre.
5 Department of Health, Kinesiology and Applied Physiology, Concordia University.

Description:

Relationship between antidepressant therapy and risk for cardiovascular events in patients with and without cardiovascular disease.

Health Psychol. 2018 Nov;37(11):989-999

Authors: Lavoie KL, Paine NJ, Pelletier R, Arsenault A, Diodati JG, Campbell TS, Pilote L, Bacon SL

Abstract

OBJECTIVE: The American Heart Association has endorsed depression as a cardiac risk factor and recommends screening as part of routine practice. This has been met with controversy due to inconsistencies in the data linking depression treatment to better cardiovascular outcomes. Our objective was to prospectively assess the association between depression treatment (defined as being prescribed antidepressant medication) and major adverse cardiovascular events (MACE) in patients referred for exercise stress tests.

METHOD: Two thousand three hundred eighty-five consecutive patients presenting for myocardial perfusion exercise stress tests underwent a sociodemographic, medical, and psychiatric interview (Primary Care Evaluation of Mental Disorders [PRIME-MD]) and completed the Beck Depression Inventory (BDI). History of cardiovascular disease (CVD) and antidepressant use was self-reported and verified via chart review. Participants followed over an 8.8-year follow up, and information regarding MACE incidence (including cardiac mortality, nonfatal myocardial infarction, revascularization procedures, cerebrovascular events) was obtained from provincial administrative databases.

RESULTS: 8% (n = 190) of the sample were taking antidepressants at baseline, 41% (n = 916) had a history of CVD, and 38.7% (n = 921) had depression according to the PRIME-MD or BDI. Antidepressant treatment was associated with a 30% reduced risk of MACE (Hazard ratio [HR] = 0.697; 95% confidence interval [CI] = [0.504, 0.964]; p = .029). A 46% reduction in risk was associated with antidepressant treatment among those without CVD (HR = 0.542; 95% CI [0.299, 0.981]; p = .043). In depressed patients, a 33% reduction in risk of MACE associated with antidepressant use was seen (adjusted HR = 0.674; 95% CI [0.440, 1.033]; p = .07).

CONCLUSIONS: Antidepressants may be cardio-protective among patients presenting for stress testing independent of risk factors including CVD and depression. Results support treating depression with antidepressants in this population to reduce risk of MACE. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

PMID: 30247064 [PubMed - indexed for MEDLINE]