Keyword search (3,619 papers available)


Appetitive olfactory conditioning in the neonatal male rat facilitates subsequent sexual partner preference.

Author(s): Ménard S, Gelez H, Jacubovitch M, Coria-Avila GA, Pfaus JG

Pairing a neutral odor with a male rat's initial sexual experiences to ejaculation produces a subsequent conditioned ejaculatory preference (CEP) in which males ejaculate preferentially with receptive females that bear the odor relative to unscented rec...

Article GUID: 32919208
Conditioning of Sexual Interests and Paraphilias in Humans Is Difficult to See, Virtually Impossible to Test, and Probably Exactly How It Happens: A Comment on Hsu and Bailey (2020).

Author(s): Pfaus JG, Quintana GR, Mac Cionnaith CE, Gerson CA, Dubé S, Coria-Avila GA

Arch Sex Behav. 2020 May 27;: Authors: Pfaus JG, Quintana GR, Mac Cionnaith CE, Gerson CA, Dubé S, Coria-Avila GA PMID: 32462414 [PubMed - as supplied by publisher]

Article GUID: 32462414
The non-aromatizable androgen dihydrotestosterone (DHT) facilitates sexual behavior in ovariectomized female rats primed with estradiol.

Author(s): Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG

Psychoneuroendocrinology. 2020 Feb 07;115:104606 Authors: Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG

Article GUID: 32087523
Correction to: Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area.

Author(s): Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Psychopharmacology (Berl). 2020 Jan 09;: Authors: Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Article GUID: 31919562
Behavior is the ultimate arbiter: An alternative explanation for the inhibitory effect of fluoxetine on the ovulatory homolog model of orgasm in rabbits.

Author(s): Quintana GR, Mac Cionnaith CE, Pfaus JG

Proc Natl Acad Sci U S A. 2019 Dec 03;: Authors: Quintana GR, Mac Cionnaith CE, Pfaus JG PMID: 31796602 [PubMed - as supplied by publisher]

Article GUID: 31796602
Fos expression is increased in oxytocin neurons of female rats with a sexually conditioned mate preference for an individual male rat.

Author(s): Mac Cionnaith CE, Lemay A, Gomez-Perales EL, Robert G, Cernik R, Brake W, Pfaus JG

Horm Behav. 2019 Oct 21;:104612 Authors: Mac Cionnaith CE, Lemay A, Gomez-Perales EL, Robert G, Cernik R, Brake W, Pfaus JG

Article GUID: 31647923
Aromatization Is Not Required for the Facilitation of Appetitive Sexual Behaviors in Ovariectomized Rats Treated With Estradiol and Testosterone.

Author(s): Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG

Front Neurosci. 2019;13:798 Authors: Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG

Article GUID: 31447629
Effect of CS preexposure on the conditioned ejaculatory preference of the male rat: behavioral analyses and neural correlates.

Author(s): Quintana GR, Jackson M, Nasr M, Pfaus JG

Learn Mem. 2018 10;25(10):513-521 Authors: Quintana GR, Jackson M, Nasr M, Pfaus JG

Article GUID: 30224554
First sexual experiences determine the development of conditioned ejaculatory preference in male rats.

Author(s): Quintana GR, Guizar A, Rassi S, Pfaus JG

Learn Mem. 2018 10;25(10):522-532 Authors: Quintana GR, Guizar A, Rassi S, Pfaus JG

Article GUID: 30224555
Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area.

Author(s): Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Psychopharmacology (Berl). 2019 Jul 29;: Authors: Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Article GUID: 31359118
Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner.

Author(s): Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A

Horm Behav. 2018 01;97:56-66 Authors: Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A

Article GUID: 29080670
Genotype scores predict drug efficacy in subtypes of female sexual interest/arousal disorder: A double-blind, randomized, placebo-controlled cross-over trial.

Author(s): Tuiten A, Michiels F, Böcker KB, Höhle D, van Honk J, de Lange RP, van Rooij K, Kessels R, Bloemers J, Gerritsen J, Janssen P, de Leede L, M...

Womens Health (Lond). 2018 Jan-Dec;14:1745506518788970 Authors: Tuiten A, Michiels F, Böcker KB, Höhle D, van Honk J, de Lange RP, van Rooij K, Kessels R, Bloemers J, Gerritsen J, Jansse...

Article GUID: 30016917
Differential role of oxytocin and vasopressin in the conditioned ejaculatory preference of the male rat.

Author(s): Ménard S, Gelez H, Girard-Bériault F, Coria-Avila G, Pfaus JG

Physiol Behav. 2019 Jun 10;:112577 Authors: Ménard S, Gelez H, Girard-Bériault F, Coria-Avila G, Pfaus JG

Article GUID: 31194998
Infusions of ascorbic acid into the medial preoptic area facilitate appetitive sexual behavior in the female rat.

Author(s): Graham MD, Pfaus JG

Physiol Behav. 2013 Oct 02;122:140-6 Authors: Graham MD, Pfaus JG

Article GUID: 24064109
Glutamate release in the ventromedial hypothalamus of the female rat during copulation: modulation by estradiol.

Author(s): Georgescu M, Afonso VM, Graham MD, Pfaus JG

Horm Behav. 2014 Feb;65(2):119-26 Authors: Georgescu M, Afonso VM, Graham MD, Pfaus JG

Article GUID: 24333845
Conditioned mate-guarding behavior in the female rat.

Author(s): Holley A, Shalev S, Bellevue S, Pfaus JG

Physiol Behav. 2014 May 28;131:136-41 Authors: Holley A, Shalev S, Bellevue S, Pfaus JG

Article GUID: 24768651
Neurobiology of social attachments.

Author(s): Coria-Avila GA, Manzo J, Garcia LI, Carrillo P, Miquel M, Pfaus JG

Neurosci Biobehav Rev. 2014 Jun;43:173-82 Authors: Coria-Avila GA, Manzo J, Garcia LI, Carrillo P, Miquel M, Pfaus JG

Article GUID: 24769402
Sensitization of sexual behaviors in ovariectomized Long-Evans rats is induced by a subthreshold dose of estradiol benzoate and attenuated by repeated copulation.

Author(s): Jones SL, Pfaus JG

Horm Behav. 2014 Sep;66(4):655-62 Authors: Jones SL, Pfaus JG

Article GUID: 25251978
The role of oxytocin and vasopressin in conditioned mate guarding behavior in the female rat.

Author(s): Holley A, Bellevue S, Vosberg D, Wenzel K, Roorda S, Pfaus JG

Physiol Behav. 2015 May 15;144:7-14 Authors: Holley A, Bellevue S, Vosberg D, Wenzel K, Roorda S, Pfaus JG

Article GUID: 25724299
The inhibitory effects of corncob bedding on sexual behavior in the ovariectomized Long-Evans rat treated with estradiol benzoate are overcome by male cues.

Author(s): Jones SL, Antonie RA, Pfaus JG

Horm Behav. 2015 Jun;72:39-48 Authors: Jones SL, Antonie RA, Pfaus JG

Article GUID: 25960082
Repeated administration of estradiol promotes mechanisms of sexual excitation and inhibition: Glutamate signaling in the ventromedial hypothalamus attenuates excitation.

Author(s): Jones SL, Farisello L, Mayer-Heft N, Pfaus JG

Behav Brain Res. 2015 Sep 15;291:118-129 Authors: Jones SL, Farisello L, Mayer-Heft N, Pfaus JG

Article GUID: 26008158
Behavioral defeminization by prenatal androgen treatment in rats can be overcome by sexual experience in adulthood.

Author(s): Jones SL, Cordeaux E, Germé K, Pfaus JG

Horm Behav. 2015 Jul;73:104-15 Authors: Jones SL, Cordeaux E, Germé K, Pfaus JG

Article GUID: 26163151
RU486 facilitates or disrupts the sensitization of sexual behaviors by estradiol in the ovariectomized Long-Evans rat: Effect of timecourse.

Author(s): Jones SL, Gardner Gregory J, Pfaus JG

Horm Behav. 2015 Sep;75:1-10 Authors: Jones SL, Gardner Gregory J, Pfaus JG

Article GUID: 26210062
Vaginocervical stimulation attenuates the sensitization of appetitive sexual behaviors by estradiol benzoate in the ovariectomized rat.

Author(s): Jones SL, Germé K, Graham MD, Roy P, Gardner Gregory J, Rosenbaum S, Parada M, Pfaus JG

Horm Behav. 2015 Sep;75:70-7 Authors: Jones SL, Germé K, Graham MD, Roy P, Gardner Gregory J, Rosenbaum S, Parada M, Pfaus JG

Article GUID: 26278846
Treatment for hypoactive sexual desire.

Author(s): Pfaus JG

Cell. 2015 Oct 22;163(3):533 Authors: Pfaus JG

Article GUID: 26496594
The Female Sexual Response: Current Models, Neurobiological Underpinnings and Agents Currently Approved or Under Investigation for the Treatment of Hypoactive Sexual Desire Disorder.

Author(s): Kingsberg SA, Clayton AH, Pfaus JG

CNS Drugs. 2015 Nov;29(11):915-33 Authors: Kingsberg SA, Clayton AH, Pfaus JG

Article GUID: 26519340
Ovarian steroids alter dopamine receptor populations in the medial preoptic area of female rats: implications for sexual motivation, desire, and behaviour.

Author(s): Graham MD, Gardner Gregory J, Hussain D, Brake WG, Pfaus JG

Eur J Neurosci. 2015 Dec;42(12):3138-48 Authors: Graham MD, Gardner Gregory J, Hussain D, Brake WG, Pfaus JG

Article GUID: 26536143
The whole versus the sum of some of the parts: toward resolving the apparent controversy of clitoral versus vaginal orgasms.

Author(s): Pfaus JG, Quintana GR, Mac Cionnaith C, Parada M

Socioaffect Neurosci Psychol. 2016;6:32578 Authors: Pfaus JG, Quintana GR, Mac Cionnaith C, Parada M

Article GUID: 27791968
The role of orgasm in the development and shaping of partner preferences.

Author(s): Coria-Avila GA, Herrera-Covarrubias D, Ismail N, Pfaus JG

Socioaffect Neurosci Psychol. 2016;6:31815 Authors: Coria-Avila GA, Herrera-Covarrubias D, Ismail N, Pfaus JG

Article GUID: 27799080
Do rats have orgasms?

Author(s): Pfaus JG, Scardochio T, Parada M, Gerson C, Quintana GR, Coria-Avila GA

Socioaffect Neurosci Psychol. 2016;6:31883 Authors: Pfaus JG, Scardochio T, Parada M, Gerson C, Quintana GR, Coria-Avila GA

Article GUID: 27799081
Persistent Genital Arousal Disorder-Fact or Fiction?

Author(s): Pfaus JG

J Sex Med. 2017 03;14(3):318-319 Authors: Pfaus JG PMID: 28262102 [PubMed]

Article GUID: 28262102
Facilitation of sexual behavior in ovariectomized rats by estradiol and testosterone: A preclinical model of androgen effects on female sexual desire.

Author(s): Jones SL, Ismail N, Pfaus JG

Psychoneuroendocrinology. 2017 05;79:122-133 Authors: Jones SL, Ismail N, Pfaus JG

Article GUID: 28278441
Efficacy and Safety of On-Demand Use of 2 Treatments Designed for Different Etiologies of Female Sexual Interest/Arousal Disorder: 3 Randomized Clinical Trials.

Author(s): Tuiten A, van Rooij K, Bloemers J, Eisenegger C, van Honk J, Kessels R, Kingsberg S, Derogatis LR, de Leede L, Gerritsen J, Koppeschaar HPF,...

J Sex Med. 2018 Feb;15(2):201-216 Authors: Tuiten A, van Rooij K, Bloemers J, Eisenegger C, van Honk J, Kessels R, Kingsberg S, Derogatis LR, de Leede L, Gerritsen J, Koppeschaar HPF, Olivier B, E...

Article GUID: 29289554
Inhibition of lysine-specific demethylase enzyme disrupts sexually conditioned mate guarding in the female rat.

Author(s): Holley A, Joulakian L, Wenzel K, Roorda S, Gonzalez B, Sparks L, Pfaus JG

Physiol Behav. 2018 11 01;196:78-83 Authors: Holley A, Joulakian L, Wenzel K, Roorda S, Gonzalez B, Sparks L, Pfaus JG

Article GUID: 30138634
Effects of ovarian hormones on the emission of 50-kHz ultrasonic vocalizations during distributed clitoral stimulation in the rat.

Author(s): Gerson CA, Mac Cionnaith CE, Quintana GR, Pfaus JG

Horm Behav. 2019 Mar;109:1-9 Authors: Gerson CA, Mac Cionnaith CE, Quintana GR, Pfaus JG

Article GUID: 30690029
Title:RU486 facilitates or disrupts the sensitization of sexual behaviors by estradiol in the ovariectomized Long-Evans rat: Effect of timecourse.
Authors:Jones SL,  Gardner Gregory J,  Pfaus JG
Link:https://www.ncbi.nlm.nih.gov/pubmed/26210062?dopt=Abstract
Category:Horm Behav
PMID:26210062
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC H4B 1R6, Canada. Electronic address: sherri.jones@concordia.ca.
2 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC H4B 1R6, Canada.

Description:

RU486 facilitates or disrupts the sensitization of sexual behaviors by estradiol in the ovariectomized Long-Evans rat: Effect of timecourse.

Horm Behav. 2015 Sep;75:1-10

Authors: Jones SL, Gardner Gregory J, Pfaus JG

Abstract

An acute injection of estradiol benzoate (EB) to the ovariectomized (OVX) rat activates low levels of lordosis, and subsequent progesterone (P) administration augments lordosis and recruits a complete pattern of sexual behavior including appetitive behaviors (e.g., hops/darts and solicitations). However, repeated injections of 5µg or 10µg EB (but not 2µg EB), administered every 4days to sexually-experienced OVX rats results in a behavioral sensitization, such that lordosis quotients (LQs) and appetitive behaviors progressively increase. We have shown that adrenal P does not play a critical role because behavioral sensitization to EB is not prevented by adrenalectomy. Here we tested whether P receptors play a role by examining the effect of chronic administration of the P receptor antagonist RU486 at a dose that reliably inhibits sexual behavior in fully primed OVX rats. Females were treated with EB (5 or 10µg), and 5mg RU486 dissolved in 0.4mL vehicle (VEH; 80% sesame oil, 15% benzyl benzoate, 5% benzyl alcohol) 48h and 5h prior to each of 7 tests, respectively, occurring at 4-day intervals in unilevel 4-hole pacing chambers. Control animals were treated with 2, 5, or 10µg EB+VEH. As expected, sensitization did not occur in females treated with 2µg EB+VEH, and those females received fewer intromissions and ejaculations than all other groups. RU486 did not prevent the sensitization of LQ, moderate and high lordosis magnitudes (LM2 and LM3) or appetitive sexual behaviors on early tests, and in fact potentiated appetitive behaviors, LQ, LM2 and LM3, consistent with its facilitative actions in females treated with EB-alone, as we and others have reported previously. However, despite the initial facilitation, blocking P receptors by chronic administration of RU486 inhibited the maintenance of behavioral sensitization to EB.

PMID: 26210062 [PubMed - indexed for MEDLINE]