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Neural correlates of resilience to the effects of hippocampal atrophy on memory.

Author(s): Belleville S, Mellah S, Cloutier S, Dang-Vu TT, Duchesne S, Maltezos S, Phillips N, Hudon C, CIMA-Q group...

INTRODUCTION: Cognitive reserve can be defined as a property of the brain that enables an individual to sustain cognitive performance in spite of age-related neural changes. This study uses brain i...

Article GUID: 33360019
The Prevalence of Hearing, Vision, and Dual Sensory Loss in Older Canadians: An Analysis of Data from the Canadian Longitudinal Study on Aging.

Author(s): Mick PT, Hämäläinen A, Kolisang L, Pichora-Fuller MK, Phillips N, Guthrie D, Wittich W

Can J Aging. 2020 Jun 17;:1-22 Authors: Mick PT, Hämäläinen A, Kolisang L, Pichora-Fuller MK, Phillips N, Guthrie D, Wittich W

Article GUID: 32546290
Sensory-cognitive associations are only weakly mediated or moderated by social factors in the Canadian Longitudinal Study on Aging.

Author(s): Hämäläinen A, Phillips N, Wittich W, Pichora-Fuller MK, Mick P

Sci Rep. 2019 Dec 23;9(1):19660 Authors: Hämäläinen A, Phillips N, Wittich W, Pichora-Fuller MK, Mick P

Article GUID: 31873079
Associations between sensory loss and social networks, participation, support, and loneliness: Analysis of the Canadian Longitudinal Study on Aging.

Author(s): Mick P, Parfyonov M, Wittich W, Phillips N, Guthrie D, Kathleen Pichora-Fuller M

Can Fam Physician. 2018 01;64(1):e33-e41 Authors: Mick P, Parfyonov M, Wittich W, Phillips N, Guthrie D, Kathleen Pichora-Fuller M

Article GUID: 29358266
The Effects of Age and Hearing Loss on Dual-Task Balance and Listening.

Author(s): Bruce H, Aponte D, St-Onge N, Phillips N, Gagné JP, Li KZH

J Gerontol B Psychol Sci Soc Sci. 2019 Jan 10;74(2):275-283 Authors: Bruce H, Aponte D, St-Onge N, Phillips N, Gagné JP, Li KZH

Article GUID: 28486677
Title:Neural correlates of resilience to the effects of hippocampal atrophy on memory.
Authors:Belleville S,  Mellah S,  Cloutier S,  Dang-Vu TT,  Duchesne S,  Maltezos S,  Phillips N,  Hudon C,  CIMA-Q group
Link:https://www.ncbi.nlm.nih.gov/pubmed/33360019
DOI:10.1016/j.nicl.2020.102526
Category:Neuroimage Clin
PMID:33360019
Dept Affiliation: HKAP
1 Research Center, Institut Universitaire de Gériatrie de Montréal. 4565 Queen Mary Rd, Montreal, QC H3W 1W5, Canada; Department of Psychology, Université de Montréal, Pavillon Marie-Victorin, 90 Vincent d'Indy, Montreal, QC H2V 2S9, Canada. Electronic address: sylvie.bellevillle@umontreal.ca.
2 Research Center, Institut Universitaire de Gériatrie de Montréal. 4565 Queen Mary Rd, Montreal, QC H3W 1W5, Canada. Electronic address: samira.mellah@criugm.qc.ca.
3 Research Center, Institut Universitaire de Gériatrie de Montréal. 4565 Queen Mary Rd, Montreal, QC H3W 1W5, Canada; Department of Psychology, Université de Montréal, Pavillon Marie-Victorin, 90 Vincent d'Indy, Montreal, QC H2V 2S9, Canada.
4 Research Center, Institut Universitaire de Gériatrie de Montréal. 4565 Queen Mary Rd, Montreal, QC H3W 1W5, Canada; Department of Health, Kinesiology and Applied Physiology, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. Electronic address: TT.DangVu@concordia.ca.
5 Department of Radiology, Université Laval, and CERVO Brain Research Center, Institut Universitaire en santé mentale de Québec, 2601 Chemin de la Canardière, Quebec City, QC G1J 2G3, Canada. Electronic address: simon.duchesne@fmed.ulaval.ca.
6 Research Center, Institut Universitaire de Gériatrie de Montréal. 4565 Queen Mary Rd, Montreal, QC H3W 1W5, Canada; Department of Psychology, Université de Montréal, Pavillon Marie-Victorin, 90 Vincent d'Indy, Montreal, QC H2V 2S9, Canada. Electronic address: sarantia.samantha.maltezos@mail.mcgill.ca.
7 Department of Psychology, Concordia University, 1455 Maisonneuve Boulevard West, Montreal, QC H3G 1M8, Canada. Electronic address: natalie.phillips@concordia.ca.
8 Department of Radiology, Université Laval, and CERVO Brain Research Center, Institut Universitaire en santé mentale de Québec, 2601 Chemin de la Canardière, Quebec City, QC G1J 2G3, Canada. Electronic address: carol.hudon@psy.ulaval.ca.

Description:

Neural correlates of resilience to the effects of hippocampal atrophy on memory.

Neuroimage Clin. 2020 Dec 07; 29:102526

Authors: Belleville S, Mellah S, Cloutier S, Dang-Vu TT, Duchesne S, Maltezos S, Phillips N, Hudon C, CIMA-Q group

Abstract

INTRODUCTION: Cognitive reserve can be defined as a property of the brain that enables an individual to sustain cognitive performance in spite of age-related neural changes. This study uses brain imaging to identify which cognitive reserve mechanisms protect against the detrimental effect of hippocampal atrophy on associative memory.

METHODS: The study included 108 older adults from the Quebec Consortium for the early identification of Alzheimer's disease. They received a magnetic resonance imaging examination to measure memory-related activations and hippocampal volume. Participants also completed a reserve-proxy questionnaire, and received a comprehensive clinical assessment.

RESULTS: Higher scores on the reserve questionnaire were associated with more activation in the right inferior temporal and left occipital fusiform gyri. The activation of the right temporal gyrus moderated the relationship between the volume of the hippocampus and face-name memory. A smaller volume was associated with weaker memory in participants with lower activation, but not in those with greater activation.

DISCUSSION: Recruitment of the temporal lobe protects against the detrimental effect of hippocampal atrophy on associative memory and contributes to cognitive reserve.

PMID: 33360019 [PubMed - as supplied by publisher]