Keyword search (3,619 papers available)


DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents.

Author(s): Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L

J Affect Disord. 2020 Jun 15;271:160-168 Authors: Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L

Article GUID: 32479312
Neuropathic pain after thoracotomy: tracking signs and symptoms before and at monthly intervals following surgery.

Author(s): Gandhi W, Pomares FB, Naso L, Asenjo JF, Schweinhardt P

Eur J Pain. 2020 Apr 08;: Authors: Gandhi W, Pomares FB, Naso L, Asenjo JF, Schweinhardt P

Article GUID: 32267038
Beyond sleepy: structural and functional changes of the default-mode network in idiopathic hypersomnia.

Author(s): Pomares FB, Boucetta S, Lachapelle F, Steffener J, Montplaisir J, Cha J, Kim H, Dang-Vu TT

Sleep. 2019 Jul 22;: Authors: Pomares FB, Boucetta S, Lachapelle F, Steffener J, Montplaisir J, Cha J, Kim H, Dang-Vu TT

Article GUID: 31328786
Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity.

Author(s): Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L

Eur Neuropsychopharmacol. 2017 10;27(10):1032-1041 Authors: Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L

Article GUID: 28774705
Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression.

Author(s): Tozzi L, Farrell C, Booij L, Doolin K, Nemoda Z, Szyf M, Pomares FB, Chiarella J, O'Keane V, Frodl T

Neuropsychopharmacology. 2018 04;43(5):1138-1145 Authors: Tozzi L, Farrell C, Booij L, Doolin K, Nemoda Z, Szyf M, Pomares FB, Chiarella J, O'Keane V, Frodl T

Article GUID: 29182159
Associations Between Daily Mood States and Brain Gray Matter Volume, Resting-State Functional Connectivity and Task-Based Activity in Healthy Adults.

Author(s): Ismaylova E, Di Sante J, Gouin JP, Pomares FB, Vitaro F, Tremblay RE, Booij L

Front Hum Neurosci. 2018;12:168 Authors: Ismaylova E, Di Sante J, Gouin JP, Pomares FB, Vitaro F, Tremblay RE, Booij L

Article GUID: 29765312
Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins.

Author(s): Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L

Transl Psychiatry. 2018 08 08;8(1):147 Authors: Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L

Article GUID: 30089832
Title:Neuropathic pain after thoracotomy: tracking signs and symptoms before and at monthly intervals following surgery.
Authors:Gandhi W,  Pomares FB,  Naso L,  Asenjo JF,  Schweinhardt P
Link:https://www.ncbi.nlm.nih.gov/pubmed/32267038?dopt=Abstract
DOI:10.1002/ejp.1569
Category:Eur J Pain
PMID:32267038
Dept Affiliation: PSYCHOLOGY
1 Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.
2 Faculty of Dentistry, McGill University, Montreal, QC, Canada.
3 Centre for Integrated Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.
4 Sleep, Cognition and Neuroimaging Laboratory, Concordia University and Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada.
5 Department of Anesthesia, Montreal General Hospital, Montreal, QC, Canada.
6 Integrative Spinal Research Group, Department of Chiropractic Medicine, University Hospital Balgrist and University of Zurich, Zurich, Switzerland.

Description:

Neuropathic pain after thoracotomy: tracking signs and symptoms before and at monthly intervals following surgery.

Eur J Pain. 2020 Apr 08;:

Authors: Gandhi W, Pomares FB, Naso L, Asenjo JF, Schweinhardt P

Abstract

BACKGROUND: Because the development of neuropathic symptoms contributes to pain severity and chronification after surgery, their early prediction is important to allow targeted treatment.

OBJECTIVES: We longitudinally investigated trajectories of signs and symptoms in patients undergoing thoracotomy and assessed whether and at which time they were related to the development of neuropathic pain symptoms six months after surgery.

METHODS: Presurgical and six, monthly postsurgical assessments included questionnaires for mental and physical well-being (e.g. depression/anxiety, pain catastrophizing, sleep quality, neuropathic pain symptoms), and quantitative sensory testing (QST).

RESULTS: QST trajectories indicated nerve impairment of the surgery site with predominant loss of function. Signs of recovery towards the end of the assessment period were observed for some tests. Unsupervised cluster analysis with NPSI scores six months after surgery as clustering variable identified one group with no/low levels of neuropathic symptoms and one with moderate levels. The two groups differed w.r.t. several signs and symptoms already at early time points. Notably, neuropathic pain anywhere in the body differed already preoperatively and sleep impairment differentiated the two groups at all time points. Regression analysis revealed three factors that seemed particularly suited to predicted six months NPSI scores, namely preoperative neuropathic pain symptoms, with contributions from sleep impairment one month after surgery and the presence of dynamic mechanical allodynia three months after surgery.

CONCLUSIONS: Clinical routine should focus on the individual's physiological state, including pre-existing neuropathic pain and sleep quality to identify patients early who might be at risk to develop chronic post-surgical neuropathic pain.

PMID: 32267038 [PubMed - as supplied by publisher]