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Ventral Midbrain NMDA Receptor Blockade: From Enhanced Reward and Dopamine Inactivation.

Author(s): Hernandez G, Cossette MP, Shizgal P, Rompré PP

Front Behav Neurosci. 2016;10:161 Authors: Hernandez G, Cossette MP, Shizgal P, Rompré PP

Article GUID: 27616984
Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors.

Author(s): Voyer D, Lévesque D, Rompré PP

Neuropharmacology. 2017 01;112(Pt A):150-163 Authors: Voyer D, Lévesque D, Rompré PP

Article GUID: 27267684
Effect of electrolytic lesions of the dorsal diencephalic conduction system on the distribution of Fos-like immunoreactivity induced by rewarding electrical stimulation.

Author(s): Fakhoury M, Voyer D, Lévesque D, Rompré PP

Neuroscience. 2016 Oct 15;334:214-225 Authors: Fakhoury M, Voyer D, Lévesque D, Rompré PP

Article GUID: 27514573
Neurotensin in the nucleus accumbens reverses dopamine supersensitivity evoked by antipsychotic treatment.

Author(s): Servonnet A, Minogianis EA, Bouchard C, Bédard AM, Lévesque D, Rompré PP, Samaha AN

Neuropharmacology. 2017 Sep 01;123:10-21 Authors: Servonnet A, Minogianis EA, Bouchard C, Bédard AM, Lévesque D, Rompré PP, Samaha AN

Article GUID: 28522313
Title:Effect of electrolytic lesions of the dorsal diencephalic conduction system on the distribution of Fos-like immunoreactivity induced by rewarding electrical stimulation.
Authors:Fakhoury M,  Voyer D,  Lévesque D,  Rompré PP
Link:https://www.ncbi.nlm.nih.gov/pubmed/27514573?dopt=Abstract
DOI:10.1016/j.neuroscience.2016.08.002
Category:Neuroscience
PMID:27514573
Dept Affiliation: CSBN
1 Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
2 Faculty of Pharmacy and FRQ-S Research Group on Central Nervous System, Université de Montréal, Montreal, Quebec, Canada.
3 Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada; FRQ-S Research Group in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada. Electronic address: pierre-paul.rompre@umontreal.ca.

Description:

Effect of electrolytic lesions of the dorsal diencephalic conduction system on the distribution of Fos-like immunoreactivity induced by rewarding electrical stimulation.

Neuroscience. 2016 Oct 15;334:214-225

Authors: Fakhoury M, Voyer D, Lévesque D, Rompré PP

Abstract

The dorsal diencephalic conduction system (DDC) is an important pathway of the brain reward circuitry, linking together forebrain and midbrain structures. The present work was aimed at describing the effect of a DDC lesion on the distribution of Fos-like immunoreactivity (FLIR) following intracranial self-stimulation (ICSS) of the lateral hypothalamus (LH). Rats were implanted with monopolar electrodes and divided into three groups; the first two groups were trained to self-stimulate at the LH, whereas the third group received no stimulation and served as a control. Among the two groups that were trained for ICSS, one of them received a lesion at the DDC and was tested for ICSS on the subsequent 5days. On the last day of testing, control rats were placed in operant chambers without receiving any stimulation, and the remaining rats were allowed to receive the stimulation for 1h. All rats were then processed for FLIR. As previously shown, a lesion at the DDC resulted in significant attenuations of the rewarding effectiveness of LH stimulation. Results also show a higher FLIR in several reward-related areas following LH stimulation, especially in the hemisphere ipsilateral to the stimulation electrode. Compared to non-lesioned rats, lesioned animals had lower FLIR in certain brain regions, suggesting that those regions that were activated by the rewarding stimulation may be functionally interconnected with the DDC.

PMID: 27514573 [PubMed - indexed for MEDLINE]