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17β-Estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo.

Author(s): Shams WM, Sanio C, Quinlan MG, Brake WG

Neuroscience. 2016 08 25;330:162-70 Authors: Shams WM, Sanio C, Quinlan MG, Brake WG

Article GUID: 27256507
Robust optical fiber patch-cords for in vivo optogenetic experiments in rats.

Author(s): Trujillo-Pisanty I, Sanio C, Chaudhri N, Shizgal P

MethodsX. 2015;2:263-71 Authors: Trujillo-Pisanty I, Sanio C, Chaudhri N, Shizgal P

Article GUID: 26150997
Optogenetic Activation of the Infralimbic Cortex Suppresses the Return of Appetitive Pavlovian-Conditioned Responding Following Extinction.

Author(s): Villaruel FR, Lacroix F, Sanio C, Sparks DW, Chapman CA, Chaudhri N

Cereb Cortex. 2018 Dec 01;28(12):4210-4221 Authors: Villaruel FR, Lacroix F, Sanio C, Sparks DW, Chapman CA, Chaudhri N

Article GUID: 29045570
Title:17β-Estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo.
Authors:Shams WM,  Sanio C,  Quinlan MG,  Brake WG
Link:https://www.ncbi.nlm.nih.gov/pubmed/27256507?dopt=Abstract
DOI:10.1016/j.neuroscience.2016.05.049
Category:Neuroscience
PMID:27256507
Dept Affiliation: PSYCHOLOGY
1 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal H4B1R6, Canada. Electronic address: waqqas19@gmail.com.
2 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal H4B1R6, Canada. Electronic address: christian.sanio@gmail.com.
3 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal H4B1R6, Canada. Electronic address: mquinlan@csusb.edu.
4 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal H4B1R6, Canada. Electronic address: wayne.brake@concordia.ca.

Description:

17ß-Estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo.

Neuroscience. 2016 08 25;330:162-70

Authors: Shams WM, Sanio C, Quinlan MG, Brake WG

Abstract

Systemic injections of 17ß-estradiol (E2) in ovariectomized (OVX) female rats rapidly enhance dorsal striatal dopamine (DA) release in response to amphetamine (AMPH). Additionally, a single injection of E2 rapidly (within 30min) enhances amphetamine-induced DA release. In situ studies show that this rapid effect of E2 occurs specifically within the dorsal striatum (DS). The present study investigated the in vivo effects of E2 infused into the DS, medial prefrontal cortex (mPFC) or the substantia nigra (SN) on dorsal striatal DA release. Rats were OVX and implanted with a silastic tube containing 5% E2 in cholesterol, previously shown to mimic low physiological serum concentrations of 18-32pg/ml. Single-probe microdialysis was used to measure extracellular DA levels in the DS. In addition, DA release was measured subsequent to systemic injections of the indirect DA agonist, AMPH (0.5mg/kg SC), administered simultaneously with E2 (0.544µg/100µl) or its vehicle, cyclodextrin (VEH) (0.520µg/100µl). Local infusions of E2 into the DS resulted in a greater amphetamine-induced dorsal striatal DA release in comparison to vehicle. Local infusions of E2 into the mPFC or the SN did not result in an enhancement of amphetamine-induced DA levels in the DS. These studies suggest that increases in dorsal striatal DA release in response to systemic E2 are a consequence of E2 actions within the DS itself.

PMID: 27256507 [PubMed - indexed for MEDLINE]