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The antibacterial activity of p-tert-butylcalix[6]arene and its effect on a membrane model: molecular dynamics and Langmuir film studies.

Author(s): Wrobel EC, de Lara LS, do Carmo TAS, Castellen P, Lazzarotto M, de Lázaro SR, Camilo A, Caseli L, Schmidt R, DeWolf CE, Wohnrath K

Phys Chem Chem Phys. 2020 Mar 03;: Authors: Wrobel EC, de Lara LS, do Carmo TAS, Castellen P, Lazzarotto M, de Lázaro SR, Camilo A, Caseli L, Schmidt R, DeWolf CE, Wohnrath K

Article GUID: 32124897
Model Lung Surfactant Films: Why Composition Matters.

Author(s): Selladurai SL, Miclette Lamarche R, Schmidt R, DeWolf CE

Langmuir. 2016 Oct 18;32(41):10767-10775 Authors: Selladurai SL, Miclette Lamarche R, Schmidt R, DeWolf CE

Article GUID: 27641759
Structural organization and phase behaviour of meta-substituted dioctadecylaminobenzoquinones at the air/water interface.

Author(s): Behyan S, Gritzalis D, Schmidt R, Kebede E, Cuccia LA, DeWolf C

Phys Chem Chem Phys. 2019 Jan 30;21(5):2345-2350 Authors: Behyan S, Gritzalis D, Schmidt R, Kebede E, Cuccia LA, DeWolf C

Article GUID: 30657501
Title:Model Lung Surfactant Films: Why Composition Matters.
Authors:Selladurai SL,  Miclette Lamarche R,  Schmidt R,  DeWolf CE
Link:https://www.ncbi.nlm.nih.gov/pubmed/27641759?dopt=Abstract
Category:Langmuir
PMID:27641759
Dept Affiliation: CNSR
1 Department of Chemistry and Biochemistry and Centre for NanoScience Research, Concordia University , 7141 Sherbrooke Street West, Montreal, Canada H4B 1R6.

Description:

Model Lung Surfactant Films: Why Composition Matters.

Langmuir. 2016 Oct 18;32(41):10767-10775

Authors: Selladurai SL, Miclette Lamarche R, Schmidt R, DeWolf CE

Abstract

Lung surfactant replacement therapies, Survanta and Infasurf, and two lipid-only systems both containing saturated and unsaturated phospholipids and one containing additional palmitic acid were used to study the impact of buffered saline on the surface activity, morphology, rheology, and structure of Langmuir monolayer model membranes. Isotherms and Brewster angle microscopy show that buffered saline subphases induce a film expansion, except when the cationic protein, SP-B, is present in sufficient quantities to already screen electrostatic repulsion, thus limiting the effect of changing pH and adding counterions. Grazing incidence X-ray diffraction results indicate an expansion not only of the liquid expanded phase but also an expansion of the lattice of the condensed phase. The film expansion corresponded in all cases with a significant reduction in the viscosity and elasticity of the films. The viscoelastic parameters are dominated by liquid expanded phase properties and do not appear to be dependent on the structure of the condensed phase domains in a phase separated film. The results highlight that the choice of subphase and film composition is important for meaningful interpretations of measurements using model systems.

PMID: 27641759 [PubMed]