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Causal evidence supporting the proposal that dopamine transients function as temporal difference prediction errors.

Author(s): Maes EJP, Sharpe MJ, Usypchuk AA, Lozzi M, Chang CY, Gardner MPH, Schoenbaum G, Iordanova MD

Nat Neurosci. 2020 Jan 20;: Authors: Maes EJP, Sharpe MJ, Usypchuk AA, Lozzi M, Chang CY, Gardner MPH, Schoenbaum G, Iordanova MD

Article GUID: 31959935
Neural correlates of two different types of extinction learning in the amygdala central nucleus.

Author(s): Iordanova MD, Deroche ML, Esber GR, Schoenbaum G

Nat Commun. 2016 08 17;7:12330 Authors: Iordanova MD, Deroche ML, Esber GR, Schoenbaum G

Article GUID: 27531638
Title:Causal evidence supporting the proposal that dopamine transients function as temporal difference prediction errors.
Authors:Maes EJP,  Sharpe MJ,  Usypchuk AA,  Lozzi M,  Chang CY,  Gardner MPH,  Schoenbaum G,  Iordanova MD
Link:https://www.ncbi.nlm.nih.gov/pubmed/31959935?dopt=Abstract
DOI:10.1038/s41593-019-0574-1
Category:Nat Neurosci
PMID:31959935
Dept Affiliation: CSBN
1 Department of Psychology/Centre for Studies in Behavioural Neurobiology, Concordia University, Montreal, Quebec, Canada.
2 Department of Psychology, University of California, Los Angeles, CA, USA.
3 Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
4 Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA. geoffrey.schoenbaum@nih.gov.
5 Departments of Anatomy & Neurobiology and Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. geoffrey.schoenbaum@nih.gov.
6 Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University, Baltimore, MD, USA. geoffrey.schoenbaum@nih.gov.
7 Department of Psychology/Centre for Studies in Behavioural Neurobiology, Concordia University, Montreal, Quebec, Canada. mihaela.iordanova@concordia.ca.

Description:

Causal evidence supporting the proposal that dopamine transients function as temporal difference prediction errors.

Nat Neurosci. 2020 Jan 20;:

Authors: Maes EJP, Sharpe MJ, Usypchuk AA, Lozzi M, Chang CY, Gardner MPH, Schoenbaum G, Iordanova MD

Abstract

Reward-evoked dopamine transients are well established as prediction errors. However, the central tenet of temporal difference accounts-that similar transients evoked by reward-predictive cues also function as errors-remains untested. In the present communication we addressed this by showing that optogenetically shunting dopamine activity at the start of a reward-predicting cue prevents second-order conditioning without affecting blocking. These results indicate that cue-evoked transients function as temporal-difference prediction errors rather than reward predictions.

PMID: 31959935 [PubMed - as supplied by publisher]