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Comparing ABA, AAB, and ABC Renewal of Appetitive Pavlovian Conditioned Responding in Alcohol- and Sucrose-Trained Male Rats.

Author(s): Khoo SY, Sciascia JM, Brown A, Chaudhri N

Front Behav Neurosci. 2020;14:5 Authors: Khoo SY, Sciascia JM, Brown A, Chaudhri N

Article GUID: 32116588
The medial prefrontal cortex is required for responding to alcohol-predictive cues but only in the absence of alcohol delivery.

Author(s): Khoo SY, Sciascia JM, Pettorelli A, Maddux JN, Chaudhri N

J Psychopharmacol. 2019 May 09;:269881119844180 Authors: Khoo SY, Sciascia JM, Pettorelli A, Maddux JN, Chaudhri N

Article GUID: 31070082
Vendor differences in alcohol consumption and the contribution of dopamine receptors to Pavlovian-conditioned alcohol-seeking in Long-Evans rats.

Author(s): Sparks LM, Sciascia JM, Ayorech Z, Chaudhri N

Psychopharmacology (Berl). 2014 Feb;231(4):753-64 Authors: Sparks LM, Sciascia JM, Ayorech Z, Chaudhri N

Article GUID: 24096535
Alcohol-Seeking Triggered by Discrete Pavlovian Cues is Invigorated by Alcohol Contexts and Mediated by Glutamate Signaling in the Basolateral Amygdala.

Author(s): Sciascia JM, Reese RM, Janak PH, Chaudhri N

Neuropsychopharmacology. 2015 Nov;40(12):2801-12 Authors: Sciascia JM, Reese RM, Janak PH, Chaudhri N

Article GUID: 25953360
Title:Vendor differences in alcohol consumption and the contribution of dopamine receptors to Pavlovian-conditioned alcohol-seeking in Long-Evans rats.
Authors:Sparks LM,  Sciascia JM,  Ayorech Z,  Chaudhri N
Link:https://www.ncbi.nlm.nih.gov/pubmed/24096535?dopt=Abstract
Category:Psychopharmacology (Berl)
PMID:24096535
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Department of Psychology, Concordia University, 7141 Sherbrooke Street West SP 244, Montreal, QC, H4B-1R6, Canada.

Description:

Vendor differences in alcohol consumption and the contribution of dopamine receptors to Pavlovian-conditioned alcohol-seeking in Long-Evans rats.

Psychopharmacology (Berl). 2014 Feb;231(4):753-64

Authors: Sparks LM, Sciascia JM, Ayorech Z, Chaudhri N

Abstract

RATIONALE: Drug-associated environmental stimuli elicit craving in humans and drug-seeking in animals.

OBJECTIVES: We tested the hypothesis that Pavlovian-conditioned alcohol-seeking is mediated by dopamine, using rats from two vendors.

METHODS: Male, Long-Evans rats (220-240 g) from Charles River (St-Constant, QC, Canada) and Harlan Laboratories (Indianapolis, IN, USA) received 21 sessions of intermittent, 24-h access to ethanol (15 %, v/v) and water in the home-cage. Subsequently, rats were trained to discriminate between one conditioned stimulus (CS+) that was paired with ethanol (0.2 ml per CS+) and a second stimulus (CS-) that was not. Entries into a fluid port where ethanol was delivered were recorded. Next, rats were exposed to a different context where cues and ethanol were withheld. At test, responding to the CS+ and CS- without ethanol was assessed in the second, non-alcohol context. Injections (1 ml/kg; s.c.) of the dopamine D1-receptor antagonist SCH 23390 (0, 3.33, and 10 µg/kg) or dopamine D2-receptor antagonist eticlopride (0, 5, and 10 µg/kg) were administered before test.

RESULTS: Home-cage alcohol consumption was higher in Harlan rats than Charles River rats. At test, saline-treated rats responded more to the alcohol-predictive CS+ than the CS-. While SCH 23390 attenuated CS+ responding in rats from both vendors, eticlopride reduced CS+ responding in Harlan rats only. Subsequently, SCH 23390 but not eticlopride attenuated CS+ responding when the CS+ was again paired with ethanol.

CONCLUSIONS: These results indicate important differences in alcohol consumption in Long-Evans rats from different suppliers, and highlight a novel role for dopamine in Pavlovian-conditioned alcohol-seeking.

PMID: 24096535 [PubMed - indexed for MEDLINE]