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The Canadian Fungal Research Network: current challenges and future opportunities.

Author(s): Horianopoulos LC, Gluck-Thaler E, Benoit Gelber I, Cowen LE, Geddes-McAlister J, Landry CR, Schwartz IS, Scott JA, Sellam A, Sheppard DC, Sp...

Can J Microbiol. 2020 Jul 27;: Authors: Horianopoulos LC, Gluck-Thaler E, Benoit Gelber I, Cowen LE, Geddes-McAlister J, Landry CR, Schwartz IS, Scott JA, Sellam A, Sheppard DC, Spribille T, Subra...

Article GUID: 32717148
The Genomic Landscape of the Fungus-Specific SWI/SNF Complex Subunit, Snf6, in Candida albicans.

Author(s): Tebbji F, Chen Y, Sellam A, Whiteway M

mSphere. 2017 Nov-Dec;2(6): Authors: Tebbji F, Chen Y, Sellam A, Whiteway M

Article GUID: 29152582
Integration of Growth and Cell Size via the TOR Pathway and the Dot6 Transcription Factor in Candida albicans.

Author(s): Chaillot J, Tebbji F, Mallick J, Sellam A

Genetics. 2019 02;211(2):637-650 Authors: Chaillot J, Tebbji F, Mallick J, Sellam A

Article GUID: 30593490
Functional divergence of a global regulatory complex governing fungal filamentation.

Author(s): Polvi EJ, Veri AO, Liu Z, Hossain S, Hyde S, Kim SH, Tebbji F, Sellam A, Todd RT, Xie JL, Lin ZY, Wong CJ, Shapiro RS, Whiteway M, Robbins N...

Functional divergence of a global regulatory complex governing fungal filamentation.

PLoS Genet. 2019 01;15(1):e1007901

Authors: Polvi EJ, Veri AO, Liu Z, Hossain S, Hyde S, Kim...

Article GUID: 30615616
Title:Integration of Growth and Cell Size via the TOR Pathway and the Dot6 Transcription Factor in Candida albicans.
Authors:Chaillot J,  Tebbji F,  Mallick J,  Sellam A
Link:https://www.ncbi.nlm.nih.gov/pubmed/30593490?dopt=Abstract
DOI:10.1534/genetics.118.301872
Category:Genetics
PMID:30593490
Dept Affiliation: BIOLOGY
1 Centre hospitalier Universitaire de Québec (CHUQ) Research Center, Université Laval, Quebec G1V 4G2, Canada.
2 Department of Biology, Concordia University, Montréal, Quebec H3G 1M8, Canada.
3 Centre hospitalier Universitaire de Québec (CHUQ) Research Center, Université Laval, Quebec G1V 4G2, Canada adnane.sellam.1@ulaval.ca.
4 Department of Microbiology, Infectious Disease and Immunology, Faculty of Medicine, Université Laval, Quebec G1V 4G2, Canada.

Description:

Integration of Growth and Cell Size via the TOR Pathway and the Dot6 Transcription Factor in Candida albicans.

Genetics. 2019 02;211(2):637-650

Authors: Chaillot J, Tebbji F, Mallick J, Sellam A

Abstract

In most species, size homeostasis appears to be exerted in late G1 phase as cells commit to division, called Start in yeast and the Restriction Point in metazoans. This size threshold couples cell growth to division, and, thereby, establishes long-term size homeostasis. Our former investigations have shown that hundreds of genes markedly altered cell size under homeostatic growth conditions in the opportunistic yeast Candida albicans, but surprisingly only few of these overlapped with size control genes in the budding yeast Saccharomyces cerevisiae Here, we investigated one of the divergent potent size regulators in C. albicans, the Myb-like HTH transcription factor Dot6. Our data demonstrated that Dot6 is a negative regulator of Start, and also acts as a transcriptional activator of ribosome biogenesis (Ribi) genes. Genetic epistasis uncovered that Dot6 interacted with the master transcriptional regulator of the G1 machinery, SBF complex, but not with the Ribi and cell size regulators Sch9, Sfp1, and p38/Hog1. Dot6 was required for carbon-source modulation of cell size, and it is regulated at the level of nuclear localization by the TOR pathway. Our findings support a model where Dot6 acts as a hub that integrates growth cues directly via the TOR pathway to control the commitment to mitotic division at G1.

PMID: 30593490 [PubMed - indexed for MEDLINE]