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Understanding low adherence to an exercise program for adolescents with obesity: the HEARTY trial.

Author(s): Alberga AS, Sigal RJ, Sweet SN, Doucette S, Russell-Mayhew S, Tulloch H, Kenny GP, Prud'homme D, Hadjiyannakis S, Goldfield GS

Obes Sci Pract. 2019 Oct;5(5):437-448 Authors: Alberga AS, Sigal RJ, Sweet SN, Doucette S, Russell-Mayhew S, Tulloch H, Kenny GP, Prud'homme D, Hadjiyannakis S, Goldfield GS

Article GUID: 31687168
Edmonton Obesity Staging System for Pediatrics, quality of life and fitness in adolescents with obesity.

Author(s): Kakon GA, Hadjiyannakis S, Sigal RJ, Doucette S, Goldfield GS, Kenny GP, Prud'homme D, Buchholz A, Lamb M, Alberga AS

Obes Sci Pract. 2019 Oct;5(5):449-458 Authors: Kakon GA, Hadjiyannakis S, Sigal RJ, Doucette S, Goldfield GS, Kenny GP, Prud'homme D, Buchholz A, Lamb M, Alberga AS

Article GUID: 31687169
Corrigendum to "Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial" Physiology & Behavior, Volume 191, 1 July 2018, Pages 138-145.

Author(s): Goldfield GS, Kenny GP, Prud'homme D, Holcik M, Alberga AS, Fahnestock M, Cameron JD, Doucette S, Hadjiyannakis S, Tulloch H, Tremblay M...

Physiol Behav. 2019 Jan 01;198:161 Authors: Goldfield GS, Kenny GP, Prud'homme D, Holcik M, Alberga AS, Fahnestock M, Cameron JD, Doucette S, Hadjiyannakis S, Tulloch H, Tremblay MS, Walsh J, ...

Article GUID: 30428994
Changes in the Brain-Derived Neurotrophic Factor Are Associated with Improvements in Diabetes Risk Factors after Exercise Training in Adolescents with Obesity: The HEARTY Randomized Controlled Trial.

Author(s): Walsh JJ, D'Angiulli A, Cameron JD, Sigal RJ, Kenny GP, Holcik M, Doucette S, Alberga AS, Prud'homme D, Hadjiyannakis S, Gunnell K, Goldfield GS

Neural Plast. 2018;2018:7169583 Authors: Walsh JJ, D'Angiulli A, Cameron JD, Sigal RJ, Kenny GP, Holcik M, Doucette S, Alberga AS, Prud'homme D, Hadjiyannakis S, Gunnell K, Goldfield GS

Article GUID: 30363954
Interindividual variability and individual responses to exercise training in adolescents with obesity.

Author(s): Walsh JJ, Bonafiglia JT, Goldfield GS, Sigal RJ, Kenny GP, Doucette S, Hadjiyannakis S, Alberga AS, Prud'homme D, Gurd BJ

Appl Physiol Nutr Metab. 2019 May 23;: Authors: Walsh JJ, Bonafiglia JT, Goldfield GS, Sigal RJ, Kenny GP, Doucette S, Hadjiyannakis S, Alberga AS, Prud'homme D, Gurd BJ

Article GUID: 31121100
Title:Changes in the Brain-Derived Neurotrophic Factor Are Associated with Improvements in Diabetes Risk Factors after Exercise Training in Adolescents with Obesity: The HEARTY Randomized Controlled Trial.
Authors:Walsh JJ,  D'Angiulli A,  Cameron JD,  Sigal RJ,  Kenny GP,  Holcik M,  Doucette S,  Alberga AS,  Prud'homme D,  Hadjiyannakis S,  Gunnell K,  Goldfield GS
Link:https://www.ncbi.nlm.nih.gov/pubmed/30363954?dopt=Abstract
Category:Neural Plast
PMID:30363954
Dept Affiliation: HKAP
1 Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
2 Department of Neuroscience, Carleton University, Ottawa, ON, Canada.
3 School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada.
4 Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
5 Departments of Medicine, Cardiac Sciences and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
6 Department of Health Sciences, Carleton University, Ottawa, ON, Canada.
7 Department of Community Health & Epidemiology, Dalhousie University, Halifax, NS, Canada.
8 Department of Exercise Science, Concordia University, Montreal, QC, Canada.
9 Institut du Savoir Montfort, Ottawa, ON, Canada.
10 Centre for Healthy Active Living, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
11 Department of Psychology, Carleton University, Ottawa, ON, Canada.
12 Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada.
13 School of Psychology, University of Ottawa, Ottawa, ON, Canada.

Description:

Changes in the Brain-Derived Neurotrophic Factor Are Associated with Improvements in Diabetes Risk Factors after Exercise Training in Adolescents with Obesity: The HEARTY Randomized Controlled Trial.

Neural Plast. 2018;2018:7169583

Authors: Walsh JJ, D'Angiulli A, Cameron JD, Sigal RJ, Kenny GP, Holcik M, Doucette S, Alberga AS, Prud'homme D, Hadjiyannakis S, Gunnell K, Goldfield GS

Abstract

Obesity in youth increases the risk of type 2 diabetes (T2D), and both are risk factors for neurocognitive deficits. Exercise attenuates the risk of obesity and T2D while improving cognitive function. In adults, these benefits are associated with the actions of the brain-derived neurotrophic factor (BDNF), a protein critical in modulating neuroplasticity, glucose regulation, fat oxidation, and appetite regulation in adults. However, little research exists in youth. This study examined the associations between changes in diabetes risk factors and changes in BDNF levels after 6 months of exercise training in adolescents with obesity. The sample consisted of 202 postpubertal adolescents with obesity (70% females) aged 14-18 years who were randomized to 6 months of aerobic and/or resistance training or nonexercise control. All participants received a healthy eating plan designed to induce a 250/kcal deficit per day. Resting serum BDNF levels and diabetes risk factors, such as fasting glucose, insulin, homeostasis model assessment (HOMA-B-beta cell insulin secretory capacity) and (HOMA-IS-insulin sensitivity), and hemoglobin A1c (HbA1c), were measured after an overnight fast at baseline and 6 months. There were no significant intergroup differences on changes in BDNF or diabetes risk factors. In the exercise group, increases in BDNF were associated with reductions in fasting glucose (ß?=?-6.57, SE?=?3.37, p = 0.05) and increases in HOMA-B (ß?=?0.093, SE?=?0.03, p = 0.004) after controlling for confounders. No associations were found between changes in diabetes risk factors and BDNF in controls. In conclusion, exercise-induced reductions in some diabetes risk factors were associated with increases in BDNF in adolescents with obesity, suggesting that exercise training may be an effective strategy to promote metabolic health and increases in BDNF, a protein favoring neuroplasticity. This trial is registered with ClinicalTrials.gov NCT00195858, September 12, 2005 (funded by the Canadian Institutes of Health Research).

PMID: 30363954 [PubMed - indexed for MEDLINE]