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Capillary electrochromatography of peptides and proteins.

Author(s): Bandilla D, Skinner CD

J Chromatogr A. 2004 Jul 30;1044(1-2):113-29 Authors: Bandilla D, Skinner CD

Article GUID: 15354432
Design and optimization of porous polymer enzymatic digestors for proteomics.

Author(s): Lin W, Skinner CD

J Sep Sci. 2009 Aug;32(15-16):2642-52 Authors: Lin W, Skinner CD

Article GUID: 19575382
Increased oxidative modifications of amniotic fluid albumin in pregnancies associated with gestational diabetes mellitus.

Author(s): Boisvert MR, Koski KG, Skinner CD

Anal Chem. 2010 Feb 01;82(3):1133-7 Authors: Boisvert MR, Koski KG, Skinner CD

Article GUID: 20063865
A case of fatal idiosyncratic reaction to the designer drug 3,4-methylenedioxypyrovalerone (MDPV) and review of the literature.

Author(s): Desharnais B, Dazé Y, Huppertz LM, Mireault P, Skinner CD

Forensic Sci Med Pathol. 2017 Sep;13(3):350-354 Authors: Desharnais B, Dazé Y, Huppertz LM, Mireault P, Skinner CD

Article GUID: 28668987
Title:Increased oxidative modifications of amniotic fluid albumin in pregnancies associated with gestational diabetes mellitus.
Authors:Boisvert MR,  Koski KG,  Skinner CD
Link:https://www.ncbi.nlm.nih.gov/pubmed/20063865?dopt=Abstract
DOI:10.1021/ac902322w
Category:Anal Chem
PMID:20063865
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University, Montreal, Quebec, Canada H4B 1R6.

Description:

Increased oxidative modifications of amniotic fluid albumin in pregnancies associated with gestational diabetes mellitus.

Anal Chem. 2010 Feb 01;82(3):1133-7

Authors: Boisvert MR, Koski KG, Skinner CD

Abstract

Gestational diabetes mellitus (GDM) is a state of hyperglycaemia and increased oxidative stress with onset during pregnancy. Human serum albumin (HSA) was extracted from 26 GDM and 26 nonGDM amniotic fluid samples collected at 15 weeks gestation and analyzed by mass spectrometry. The majority of all albumin isoforms were oxidized with the cysteinylated HSA as the base peak in the deconvoluted spectrum. The HSA peak areas, from a control sample, had 36% relative standard deviation (RSD) across the six experimental days but using the relative isoform distribution improved the precision to 3-6%. The results show that the relative contribution of permanently oxidized HSA was greater (P = 0.002) and reversibly oxidized HSA was lower (P = 0.006) for GDM compared to nonGDM in the samples measured. This implies that the path toward GDM has been set prior to 15 weeks gestation and results in increased protein oxidation.

PMID: 20063865 [PubMed - indexed for MEDLINE]