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Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection

Author(s): Véronik Lachance

For the past several years, fundamental research on Sigma-1R (S1R) protein has unveiled its necessity for maintaining proper cellular homeostasis through modulation of calcium and lipid exchange between the endoplasmic reticulum (ER) and mitochondria, ER-st...

Article GUID: 36768299
Title:Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection
Authors:Véronik Lachance
Link:https://pubmed.ncbi.nlm.nih.gov/36768299/
DOI:10.3390/ijms24031971
Category:
PMID:36768299
Dept Affiliation: CSBN
1 Département des Sciences Biologiques, Université du Québec à Montréal, 141 Avenue du Président-Kennedy, Montréal, QC H2X 3X8, Canada.
2 Centre d'Excellence en Recherche sur les Maladies Orphelines-Fondation Courtois, Pavillon des Sciences biologiques, 141 Avenue du Président-Kennedy, Montréal, QC H2X 3Y7, Canada.
3 Département de Chimie, Université du Québec à Montréal, 2101, Rue Jeanne-Mance, Montréal, QC H2X 2J6, Canada.
4 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada.

Description:

For the past several years, fundamental research on Sigma-1R (S1R) protein has unveiled its necessity for maintaining proper cellular homeostasis through modulation of calcium and lipid exchange between the endoplasmic reticulum (ER) and mitochondria, ER-stress response, and many other mechanisms. Most of these processes, such as ER-stress response and autophagy, have been associated with neuroprotective roles. In fact, improving these mechanisms using S1R agonists was beneficial in several...