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A Crowdsensing Based Analytical Framework for Perceptional Degradation of OTT Web Browsing.

Author(s): Li K, Wang H, Xu X, Du Y, Liu Y, Ahmad MO

Sensors (Basel). 2018 May 15;18(5): Authors: Li K, Wang H, Xu X, Du Y, Liu Y, Ahmad MO

Article GUID: 29762493
Big Data-Driven Cellular Information Detection and Coverage Identification.

Author(s): Wang H, Xie S, Li K, Ahmad MO

Sensors (Basel). 2019 Feb 22;19(4): Authors: Wang H, Xie S, Li K, Ahmad MO

Article GUID: 30813353
Pre-treatment EEG signal variability is associated with treatment success in depression.

Author(s): Jaworska N, Wang H, Smith DM, Blier P, Knott V, Protzner AB

Neuroimage Clin. 2018;17:368-377 Authors: Jaworska N, Wang H, Smith DM, Blier P, Knott V, Protzner AB

Article GUID: 29159049
Smart Self-Assembled Nanosystem Based on Water-Soluble Pillararene and Rare-Earth-Doped Upconversion Nanoparticles for pH-Responsive Drug Delivery.

Author(s): Li H, Wei R, Yan GH, Sun J, Li C, Wang H, Shi L, Capobianco JA, Sun L

ACS Appl Mater Interfaces. 2018 Feb 07;10(5):4910-4920 Authors: Li H, Wei R, Yan GH, Sun J, Li C, Wang H, Shi L, Capobianco JA, Sun L

Article GUID: 29336139
Title:Smart Self-Assembled Nanosystem Based on Water-Soluble Pillararene and Rare-Earth-Doped Upconversion Nanoparticles for pH-Responsive Drug Delivery.
Authors:Li H,  Wei R,  Yan GH,  Sun J,  Li C,  Wang H,  Shi L,  Capobianco JA,  Sun L
Link:https://www.ncbi.nlm.nih.gov/pubmed/29336139?dopt=Abstract
Category:ACS Appl Mater Interfaces
PMID:29336139
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry and Center for Nanoscience Research, Concordia University , 7141 Sherbrooke Sreet West, Montreal, QC H4B 1R6, Canada.

Description:

Smart Self-Assembled Nanosystem Based on Water-Soluble Pillararene and Rare-Earth-Doped Upconversion Nanoparticles for pH-Responsive Drug Delivery.

ACS Appl Mater Interfaces. 2018 Feb 07;10(5):4910-4920

Authors: Li H, Wei R, Yan GH, Sun J, Li C, Wang H, Shi L, Capobianco JA, Sun L

Abstract

Exploring novel drug delivery systems with good stability and new structure to integrate pillararene and upconversion nanoparticles (UCNPs) into one system continues to be an important challenge. Herein, we report a novel preparation of a supramolecular upconversion nanosystem via the host-guest complexation based on carboxylate-based pillar[5]arene (WP5) and 15-carboxy-N,N,N-trialkylpentadecan-1-ammonium bromide (1)-functionalized UCNPs to produce WP5?1-UCNPs that can be loaded with the chemotherapeutic drug doxorubicin (DOX). Importantly, the WP5 on the surface of the drug-loaded nanosystem can be efficiently protonated under acidic conditions, resulting in the collapse of the nanosystem and drug release. Moreover, cellular uptake confirms that the nanosystem can enter human cervical cancer (HeLa) cells, resulting in drug accumulation in the cells. More importantly, cytotoxicity experiments demonstrated the excellent biocompatibility of WP5?1-UCNPs without loading DOX and that the nanosystem DOX-WP5?1-UCNPs exhibited an ability of killing HeLa cells effectively. We also investigated magnetic resonance imaging and upconversion luminescence imaging, which may be employed as visual imaging agents in cancer diagnosis and treatment. Thus, in the present work, we show a simple yet powerful strategy to combine UCNPs and pillar[5]arene to produce a unified nanosystem for dual-mode bioimaging-guided therapeutic applications.

PMID: 29336139 [PubMed - indexed for MEDLINE]