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Effects of perirhinal cortex and hippocampal lesions on rats' performance on two object-recognition tasks.

Author(s): Cole E, Ziadé J, Simundic A, Mumby DG

Behav Brain Res. 2019 Dec 23;:112450 Authors: Cole E, Ziadé J, Simundic A, Mumby DG

Article GUID: 31877339
Parallel contributions of cerebellar, striatal and M1 mechanisms to motor sequence learning

Author(s): Penhune VB; Steele CJ;

When learning a new motor sequence, we must execute the correct order of movements while simultaneously optimizing sensorimotor parameters such as trajectory, timing, velocity and force. Neurophysiological studies in animals and humans have identified the m...

Article GUID: 22004979
Repeated administration of estradiol promotes mechanisms of sexual excitation and inhibition: Glutamate signaling in the ventromedial hypothalamus attenuates excitation.

Author(s): Jones SL, Farisello L, Mayer-Heft N, Pfaus JG

Behav Brain Res. 2015 Sep 15;291:118-129 Authors: Jones SL, Farisello L, Mayer-Heft N, Pfaus JG

Article GUID: 26008158
The neural substrates for the rewarding and dopamine-releasing effects of medial forebrain bundle stimulation have partially discrepant frequency responses.

Author(s): Cossette MP, Conover K, Shizgal P

Behav Brain Res. 2016 Jan 15;297:345-58 Authors: Cossette MP, Conover K, Shizgal P

Article GUID: 26477378
Effects of chronic prenatal MK-801 treatment on object recognition, cognitive flexibility, and drug-induced locomotor activity in juvenile and adult rat offspring.

Author(s): Gallant S, Welch L, Martone P, Shalev U

Behav Brain Res. 2017 06 15;328:62-69 Authors: Gallant S, Welch L, Martone P, Shalev U

Article GUID: 28390877
Title:Effects of chronic prenatal MK-801 treatment on object recognition, cognitive flexibility, and drug-induced locomotor activity in juvenile and adult rat offspring.
Authors:Gallant S,  Welch L,  Martone P,  Shalev U
Link:https://www.ncbi.nlm.nih.gov/pubmed/28390877?dopt=Abstract
Category:Behav Brain Res
PMID:28390877
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Québec, Canada, H4B 1R6.
2 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Québec, Canada, H4B 1R6. Electronic address: uri.shalev@concordia.ca.

Description:

Effects of chronic prenatal MK-801 treatment on object recognition, cognitive flexibility, and drug-induced locomotor activity in juvenile and adult rat offspring.

Behav Brain Res. 2017 06 15;328:62-69

Authors: Gallant S, Welch L, Martone P, Shalev U

Abstract

BACKGROUND: Patients with schizophrenia display impaired cognitive functioning and increased sensitivity to psychomimetic drugs. The neurodevelopmental hypothesis of schizophrenia posits that disruption of the developing brain predisposes neural networks to lasting structural and functional abnormalities resulting in the emergence of such symptoms in adulthood. Given the critical role of the glutamatergic system in early brain development, we investigated whether chronic prenatal exposure to the glutamate NMDA receptor antagonist, MK-801, induces schizophrenia-like behavioural and neurochemical changes in juvenile and adult rats.

METHODS: Pregnant Long-Evans rats were administered saline or MK-801 (0.1mg/kg; s.c.) at gestation day 7-19. Object recognition memory and cognitive flexibility were assessed in the male offspring using a novel object preference task and a maze-based set-shifting procedure, respectively. Locomotor-activating effects of acute amphetamine and MK-801 were also assessed.

RESULTS: Adult, but not juvenile, prenatally MK-801-treated rats failed to show novel object preference after a 90min delay, suggesting that object recognition memory may have been impaired. In addition, the set-shifting task revealed impaired acquisition of a new rule in adult prenatally MK-801-treated rats compared to controls. This deficit appeared to be driven by regression to the previously learned behaviour. There were no significant differences in drug-induced locomotor activity in juvenile offspring or in adult offspring following acute amphetamine challenges. Unexpectedly, MK-801-induced locomotor activity in adult prenatally MK-801-treated rats was lower compared to controls.

CONCLUSIONS: Glutamate transmission dysfunction during early development may modify behavioural parameters in adulthood, though these parameters do not appear to model deficits observed in schizophrenia.

PMID: 28390877 [PubMed - indexed for MEDLINE]