Keyword search (3,448 papers available)


Cannabis Exposure Enhances Subcortical Control of Nucleus Accumbens Activity.

Author(s): Lafferty CK; Britt JP;

Biol Psychiatry. 2020 04 01; 87(7):592-594 Authors: Lafferty CK, Britt JP PMID: 32164914 [PubMed - indexed for MEDLINE]

Article GUID: 32164914
Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability.

Author(s): Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP

Biol Psychiatry. 2019 Sep 19;: Authors: Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP

Article GUID: 31699294
Endocannabinoids promote cocaine-induced impulsivity and its rapid dopaminergic correlates.

Author(s): Hernandez G, Oleson EB, Gentry RN, Abbas Z, Bernstein DL, Arvanitogiannis A, Cheer JF

Biol Psychiatry. 2014 Mar 15;75(6):487-98 Authors: Hernandez G, Oleson EB, Gentry RN, Abbas Z, Bernstein DL, Arvanitogiannis A, Cheer JF

Article GUID: 24138924
Circadian Rhythms and Psychopathology: From Models of Depression to Rhythms in Clock Gene Expression and Back Again.

Author(s): Verwey M, Al-Safadi S, Amir S

Biol Psychiatry. 2015 Aug 15;78(4):220-1 Authors: Verwey M, Al-Safadi S, Amir S PMID: 26195175 [PubMed - indexed for MEDLINE]

Article GUID: 26195175
Title:Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability.
Authors:Yang AK,  Mendoza JA,  Lafferty CK,  Lacroix F,  Britt JP
Link:https://www.ncbi.nlm.nih.gov/pubmed/31699294?dopt=Abstract
DOI:10.1016/j.biopsych.2019.09.007
Category:Biol Psychiatry
PMID:31699294
Dept Affiliation: CSBN
1 Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
2 Department of Psychology, McGill University, Montreal, Quebec, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
3 Department of Psychology, McGill University, Montreal, Quebec, Canada.
4 Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada; Department of Psychology, McGill University, Montreal, Quebec, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada. Electronic address: jonathan.britt@mcgill.ca.

Description:

Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability.

Biol Psychiatry. 2019 Sep 19;:

Authors: Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP

Abstract

BACKGROUND: Insight into the neural basis of hedonic processing has come from studies of food palatability in rodents. Pharmacological manipulations of the nucleus accumbens shell (NAcSh) have repeatedly been demonstrated to increase hedonic taste reactivity, yet the contribution of specific NAcSh circuit components is unknown.

METHODS: Bidirectional optogenetic manipulations were targeted to the principal NAcSh projection neurons and afferent pathways in mice during free feeding assays. Number of licks per bout of consumption was used as a measure of food palatability as it was confirmed to track sucrose concentration and subjective flavor preferences.

RESULTS: Photoinhibition of NAcSh neurons, whether general or cell-type specific, was found to alter consumption without affecting its hedonic impact. Among the principal excitatory afferent pathways, we showed that ventral hippocampal (vHipp) input alone enhances palatability upon low-frequency photostimulation time-locked to consumption. This enhancement in palatability was independent of opioid signaling and not recapitulated by NAcSh or dopamine neuron photostimulation. We further demonstrated that vHipp input photostimulation is sufficient to condition a flavor preference, while its inhibition impedes sucrose-driven flavor preference conditioning.

CONCLUSIONS: These results demonstrate a novel contribution of vHipp-NAcSh pathway activity to palatability that may relate to its innervation of a particular region or neuronal ensemble in the NAcSh. These findings are consistent with the evidence that vHipp-NAcSh activity is relevant to the pathophysiology of anhedonia and depression as well as the increasing appreciation of hippocampal involvement in people's food pleasantness ratings, hunger, and weight.

PMID: 31699294 [PubMed - as supplied by publisher]