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Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.

Author(s): Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Cell Rep. 2020 Jun 30;31(13):107838 Authors: Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Article GUID: 32610139
Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking.

Author(s): Lafferty CK, Yang AK, Mendoza JA, Britt JP

Cell Rep. 2020 Mar 17;30(11):3729-3742.e3 Authors: Lafferty CK, Yang AK, Mendoza JA, Britt JP

Article GUID: 32187545
Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value.

Author(s): Mendoza JA, Lafferty CK, Yang AK, Britt JP

Cell Rep. 2019 Nov 05;29(6):1429-1437.e3 Authors: Mendoza JA, Lafferty CK, Yang AK, Britt JP

Article GUID: 31693885
Title:Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value.
Authors:Mendoza JA,  Lafferty CK,  Yang AK,  Britt JP
Link:https://www.ncbi.nlm.nih.gov/pubmed/31693885?dopt=Abstract
Category:Cell Rep
PMID:31693885
Dept Affiliation: CSBN
1 Department of Psychology, McGill University, Montreal, QC H3A 1B1, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada.
2 Integrated Program in Neuroscience, McGill University, Montreal, QC H3A 2B4, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada.
3 Department of Psychology, McGill University, Montreal, QC H3A 1B1, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC H3A 2B4, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada. Electronic address: jonathan.britt@mcgill.ca.

Description:

Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value.

Cell Rep. 2019 Nov 05;29(6):1429-1437.e3

Authors: Mendoza JA, Lafferty CK, Yang AK, Britt JP

Abstract

Cue-evoked midbrain dopamine (DA) neuron activity reflects expected value, but its influence on reward assessment is unclear. In mice performing a trial-based operant task, we test if bidirectional manipulations of cue or operant-associated DA neuron activity drive learning as a result of under- or overexpectation of reward value. We target optogenetic manipulations to different components of forced trials, when only one lever is presented, and assess lever biases on choice trials in the absence of photomanipulation. Although lever biases are demonstrated to be flexible and sensitive to changes in expected value, augmentation of cue or operant-associated DA signaling does not significantly alter choice behavior, and blunting DA signaling during any component of the forced trials reduces choice trial responses on the associated lever. These data suggest cue-evoked DA helps maintain cue-value associations but does not encode expected value as to set the benchmark against which received reward is judged.

PMID: 31693885 [PubMed - in process]