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Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing.

Author(s): Copp W, Pontarelli A, Wilds CJ

The chemical and self-assembly properties of nucleic acids make them ideal for the construction of discrete structures and stimuli-responsive devices for a diverse array of applications. Amongst the various three-dimensional assemblies, DNA tetrahedra are o...

Article GUID: 33506614
AGT Activity Towards Intrastrand Crosslinked DNA is Modulated by the Alkylene Linker.

Author(s): O'Flaherty DK, Wilds CJ

Chembiochem. 2017 12 05;18(23):2351-2357 Authors: O'Flaherty DK, Wilds CJ

Article GUID: 28980757
O4 -Alkylated-2-Deoxyuridine Repair by O6 -Alkylguanine DNA Alkyltransferase is Augmented by a C5-Fluorine Modification

Author(s): Lauralicia Sacre

Oligonucleotides containing various adducts, including ethyl, benzyl, 4-hydroxybutyl and 7-hydroxyheptyl groups, at the O4 atom of 5-fluoro-O4 -alkyl-2'-deoxyuridine were prepared by solid-phase synthesis. UV thermal denaturation studies demonstrated th...

Article GUID: 29243336
Title:Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing.
Authors:Copp W,  Pontarelli A,  Wilds CJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/33506614
DOI:10.1002/cbic.202000835
Category:Chembiochem
PMID:33506614
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University, Montréal, Québec, H4B 1R6, Canada.

Description:

Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing.

Chembiochem. 2021 Jan 27; :

Authors: Copp W, Pontarelli A, Wilds CJ

Abstract

The chemical and self-assembly properties of nucleic acids make them ideal for the construction of discrete structures and stimuli-responsive devices for a diverse array of applications. Amongst the various three-dimensional assemblies, DNA tetrahedra are of particular interest as these structures have been shown to be readily taken up by the cell without the need for transfecting agents via the process of caveolin mediated endocytosis. Moreover, these structures can be readily modified with a diverse range of pendant groups to confer greater functionality. This minireview highlights recent examples of advances related to applications of this interesting DNA structure including the delivery of therapeutic agents ranging from small molecules to oligonucleotides in addition to its utilization for sensing and imaging of various species within the cell.

PMID: 33506614 [PubMed - as supplied by publisher]