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The priming effect of food persists following blockade of dopamine receptors.

Author(s): Evangelista C, Hantson A, Shams WM, Almey A, Pileggi M, Voisard JR, Boulos V, Al-Qadri Y, Gonzalez Cautela BV, Zhou FX, Duchemin J, Habrich ...

Eur J Neurosci. 2019 Jul 27;: Authors: Evangelista C, Hantson A, Shams WM, Almey A, Pileggi M, Voisard JR, Boulos V, Al-Qadri Y, Gonzalez Cautela BV, Zhou FX, Duchemin J, Habrich A, Tito N, Koumro...

Article GUID: 31350860

Ovarian steroids alter dopamine receptor populations in the medial preoptic area of female rats: implications for sexual motivation, desire, and behaviour.

Author(s): Graham MD, Gardner Gregory J, Hussain D, Brake WG, Pfaus JG

Eur J Neurosci. 2015 Dec;42(12):3138-48 Authors: Graham MD, Gardner Gregory J, Hussain D, Brake WG, Pfaus JG

Article GUID: 26536143

Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatum

Author(s): Minogianis EA; Shams WM; Mabrouk OS; Wong JT; Brake WG; Kennedy RT; du Souich P; Samaha AN;...

The faster drugs of abuse reach the brain, the greater is the risk of addiction. Even small differences in the rate of drug delivery can influence outcome. Infusing cocaine intravenously over 5 vs....

Article GUID: 29757478


Title:Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatum
Authors:Minogianis EAShams WMMabrouk OSWong JTBrake WGKennedy RTdu Souich PSamaha AN
Link:https://pubmed.ncbi.nlm.nih.gov/29757478/
DOI:10.1111/ejn.13941
Category:Eur J Neurosci
PMID:29757478
Dept Affiliation: MASSSPEC
1 Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montreal, QC, H3C 3J7, Canada.
2 Department of Psychology, Center for Studies in Behavioral Neurobiology (CSBN), Concordia University, Montreal, QC, Canada.
3 Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA.
4 Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.
5 Groupe de recherche sur le système nerveux central, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

Description:

The faster drugs of abuse reach the brain, the greater is the risk of addiction. Even small differences in the rate of drug delivery can influence outcome. Infusing cocaine intravenously over 5 vs. 90-100 s promotes sensitization to the psychomotor and incentive motivational effects of the drug and preferentially recruits mesocorticolimbic regions. It remains unclear whether these effects are due to differences in how fast and/or how much drug reaches the brain. Here, we predicted that varying the rate of intravenous cocaine infusion between 5 and 90 s produces different rates of rise of brain drug concentrations, while producing similar peak concentrations. Freely moving male Wistar rats received acute intravenous cocaine infusions (2.0 mg/kg/infusion) over 5, 45 and 90 s. We measured cocaine concentrations in the dorsal striatum using rapid-sampling microdialysis (1 sample/min) and high-performance liquid chromatography-tandem mass spectrometry. We also measured extracellular concentrations of dopamine and other neurochemicals. Regardless of infusion rate, acute cocaine did not change concentrations of non-dopaminergic neurochemicals. Infusion rate did not significantly influence peak concentrations of cocaine or dopamine, but concentrations increased faster following 5-s infusions. We also assessed psychomotor activity as a function of cocaine infusion rate. Infusion rate did not significantly influence total locomotion, but locomotion increased earlier following 5-s infusions. Thus, small differences in the rate of cocaine delivery influence both the rate of rise of drug and dopamine concentrations, and psychomotor activity. A faster rate of rise of drug and dopamine concentrations might be an important issue in making rapidly delivered cocaine more addictive.