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Congenital Deafness Leads to Altered Overt Oculomotor Behaviors.

Author(s): Sharp A, Turgeon C, Johnson AP, Pannasch S, Champoux F, Ellemberg D

Front Neurosci. 2020;14:273 Authors: Sharp A, Turgeon C, Johnson AP, Pannasch S, Champoux F, Ellemberg D

Article GUID: 32327967
Inferior Longitudinal Fasciculus' Role in Visual Processing and Language Comprehension: A Combined MEG-DTI Study.

Author(s): Shin J, Rowley J, Chowdhury R, Jolicoeur P, Klein D, Grova C, Rosa-Neto P, Kobayashi E

Front Neurosci. 2019;13:875 Authors: Shin J, Rowley J, Chowdhury R, Jolicoeur P, Klein D, Grova C, Rosa-Neto P, Kobayashi E

Article GUID: 31507359
Aromatization Is Not Required for the Facilitation of Appetitive Sexual Behaviors in Ovariectomized Rats Treated With Estradiol and Testosterone.

Author(s): Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG

Front Neurosci. 2019;13:798 Authors: Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG

Article GUID: 31447629
Processing of Acoustic Information in Lexical Tone Production and Perception by Pediatric Cochlear Implant Recipients.

Author(s): Deroche MLD, Lu HP, Lin YS, Chatterjee M, Peng SC

Front Neurosci. 2019;13:639 Authors: Deroche MLD, Lu HP, Lin YS, Chatterjee M, Peng SC

Article GUID: 31281237
Influence of Head Tissue Conductivity Uncertainties on EEG Dipole Reconstruction.

Author(s): Vorwerk J, Aydin Ü, Wolters CH, Butson CR

Front Neurosci. 2019;13:531 Authors: Vorwerk J, Aydin Ü, Wolters CH, Butson CR

Article GUID: 31231178
Partially Overlapping Brain Networks for Singing and Cello Playing.

Author(s): Segado M, Hollinger A, Thibodeau J, Penhune V, Zatorre RJ

Front Neurosci. 2018;12:351 Authors: Segado M, Hollinger A, Thibodeau J, Penhune V, Zatorre RJ

Article GUID: 29892211
Integrated fMRI Preprocessing Framework Using Extended Kalman Filter for Estimation of Slice-Wise Motion.

Author(s): Pinsard B, Boutin A, Doyon J, Benali H

Front Neurosci. 2018;12:268 Authors: Pinsard B, Boutin A, Doyon J, Benali H

Article GUID: 29755312
Detection of abnormal resting-state networks in individual patients suffering from focal epilepsy: an initial step toward individual connectivity assessment.

Author(s): Dansereau CL, Bellec P, Lee K, Pittau F, Gotman J, Grova C

Front Neurosci. 2014;8:419 Authors: Dansereau CL, Bellec P, Lee K, Pittau F, Gotman J, Grova C

Article GUID: 25565949
The Music-In-Noise Task (MINT): A Tool for Dissecting Complex Auditory Perception.

Author(s): Coffey EBJ, Arseneau-Bruneau I, Zhang X, Zatorre RJ

Front Neurosci. 2019;13:199 Authors: Coffey EBJ, Arseneau-Bruneau I, Zhang X, Zatorre RJ

Article GUID: 30930734
Title:Aromatization Is Not Required for the Facilitation of Appetitive Sexual Behaviors in Ovariectomized Rats Treated With Estradiol and Testosterone.
Authors:Jones SL,  Rosenbaum S,  Gardner Gregory J,  Pfaus JG
Link:https://www.ncbi.nlm.nih.gov/pubmed/31447629?dopt=Abstract
DOI:10.3389/fnins.2019.00798
Category:Front Neurosci
PMID:31447629
Dept Affiliation: CSBN
1 Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.

Description:

Aromatization Is Not Required for the Facilitation of Appetitive Sexual Behaviors in Ovariectomized Rats Treated With Estradiol and Testosterone.

Front Neurosci. 2019;13:798

Authors: Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG

Abstract

Testosterone can be safely and effectively administered to estrogen-treated post-menopausal women experiencing hypoactive sexual desire. However, in the United States and Canada, although it is often administered off-label, testosterone co-administered with estradiol is not a federally approved treatment for sexual arousal/desire disorder, partly because its mechanism is poorly understood. One possible mechanism involves the aromatization of testosterone to estradiol. In an animal model, the administration of testosterone propionate (TP) given in combination with estradiol benzoate (EB) significantly increases sexually appetitive behaviors (i.e., solicitations and hops/darts) in ovariectomized (OVX) Long-Evans rats, compared to those treated with EB-alone. The goal of current study was to test whether blocking aromatization of testosterone to estradiol would disrupt the facilitation of sexual behaviors in OVX Long-Evans rats, and to determine group differences in Fos immunoreactivity within brain regions involved in sexual motivation and reward. Groups of sexually experienced OVX Long-Evans rats were treated with EB alone, EB+TP, or EB+TP and the aromatase inhibitor Fadrozole (EB+TP+FAD). Females treated with EB+TP+FAD displayed significantly more hops and darts, solicitations and lordosis magnitudes when compared to EB-alone females. Furthermore, TP, administered with or without FAD, induced the activation of Fos-immunoreactivity in brain areas implicated in sexual motivation and reward including the medial preoptic area, ventrolateral division of the ventromedial nucleus of the hypothalamus, the nucleus accumbens core, and the prefrontal cortex. These results suggest that aromatization may not be necessary for TP to enhance female sexual behavior and that EB+TP may act via androgenic pathways to increase the sensitivity of response to male-related cues, to induce female sexual desire.

PMID: 31447629 [PubMed]